Lineage for Protein: Snake phospholipase A2

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2011697Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  4. 2011698Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (4 families) (S)
  5. 2011703Family a.133.1.2: Vertebrate phospholipase A2 [48623] (3 protein domains)
    automatically mapped to Pfam PF00068
  6. 2011813Protein Snake phospholipase A2 [48624] (38 species)

Species:

  1. 2011814Andaman cobra (Naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
  2. 2011816Andaman cobra (Naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    1. Domain for 1mh7:
    2. Domain for 1mh8:
      • 2011817Domain d1mh8a_: 1mh8 A: [84963]
        possibly another isoform with isoleucine at second position
  3. 2011819Andaman cobra (Naja sagittifera), isoform 2 [TaxId:195058] [89169] (4 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 2011822Domain d1mh2a_: 1mh2 A: [84960]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 2011820Domain d1s6ba_: 1s6b A: [98592]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
    3. Domain for 1xxw:
    4. Domain for 2rd4:
  4. 2011824Andaman cobra (Naja sagittifera), isoform 3 [TaxId:195058] [89170] (4 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 2011827Domain d1mh2b_: 1mh2 B: [84961]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 2011825Domain d1s6bb_: 1s6b B: [98593]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
    3. Domain for 1xxw:
    4. Domain for 2rd4:
  5. 2011829Andaman cobra (Naja sagittifera), isoform 4 [TaxId:195058] [89171] (14 PDB entries)
    Uniprot P60045 8-126 # ! yet another isoform, 98% identity
    1. Domain for 1ln8:
    2. Domain for 1mf4:
      • 2011837Domain d1mf4a_: 1mf4 A: [91261]
        complexed with a designed peptide inhibitor
        complexed with ca
    3. Domain for 1oxr:
    4. Domain for 1t37:
    5. Domain for 1td7:
    6. Domain for 1yxl:
    7. Domain for 1zm6:
    8. Domain for 3gci:
    9. Domain for 3jq5:
    10. Domain for 3jql:
    11. Domain for 3jti:
    12. Domain for 3nju:
    13. Domain for 3osh:
    14. Domain for 3q4y:
  6. 2011844Bothrops brazili [TaxId:157546] [228951] (1 PDB entry)
  7. 2011847Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (3 PDB entries)
    1. Domains for 1qll:
      1. 2011852Domain d1qlla_: 1qll A: [19556]
        complexed with tda
      2. 2011853Domain d1qllb_: 1qll B: [19557]
        complexed with tda
    2. Domains for 2q2j:
      1. 2011848Domain d2q2ja_: 2q2j A: [167397]
        automated match to d1qlla_
        complexed with so4, trs
      2. 2011849Domain d2q2jb_: 2q2j B: [167398]
        automated match to d1qlla_
        complexed with so4, trs
    3. Domains for 3cyl:
      1. 2011850Domain d3cyla_: 3cyl A: [173545]
        automated match to d1qlla_
        complexed with pe4, so4, vit
      2. 2011851Domain d3cylb_: 3cyl B: [173546]
        automated match to d1qlla_
        complexed with pe4, so4, vit
  8. 2011854Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
    1. Domain for 1s8g:
    2. Domain for 1s8h:
    3. Domain for 1s8i:
  9. 2011858Cerrophidion godmani, formerly Bothrops godmani [TaxId:44722] [48645] (1 PDB entry)
    Monomeric Lys-49 phospholipase A2 homologue
  10. 2011860Eastern cottonmouth snake (Agkistrodon piscivorus piscivorus) [TaxId:8716] [48629] (2 PDB entries)
    1. Domain for 1ppa:
    2. Domains for 1vap:
      1. 2011861Domain d1vapa_: 1vap A: [19548]
      2. 2011862Domain d1vapb_: 1vap B: [19549]
  11. 2011864Halys viper (Agkistrodon halys) [TaxId:8714] [48628] (9 PDB entries)
    1. Domains for 1a2a:
      1. 2011885Domain d1a2aa_: 1a2a A: [19540]
        complexed with cl
      2. 2011886Domain d1a2ab_: 1a2a B: [19541]
        complexed with cl
      3. 2011887Domain d1a2ac_: 1a2a C: [19542]
        complexed with cl
      4. 2011888Domain d1a2ad_: 1a2a D: [19543]
        complexed with cl
      5. 2011889Domain d1a2ae_: 1a2a E: [19544]
        complexed with cl
      6. 2011890Domain d1a2af_: 1a2a F: [19545]
        complexed with cl
      7. 2011891Domain d1a2ag_: 1a2a G: [19546]
        complexed with cl
      8. 2011892Domain d1a2ah_: 1a2a H: [19547]
        complexed with cl
    2. Domains for 1b4w:
      1. 2011871Domain d1b4wa_: 1b4w A: [19536]
        complexed with bog
      2. 2011872Domain d1b4wb_: 1b4w B: [19537]
        complexed with bog
      3. 2011873Domain d1b4wc_: 1b4w C: [19538]
        complexed with bog
      4. 2011874Domain d1b4wd_: 1b4w D: [19539]
        complexed with bog
    3. Domains for 1bjj:
      1. 2011875Domain d1bjja_: 1bjj A: [19530]
        complexed with ca
      2. 2011876Domain d1bjjb_: 1bjj B: [19531]
        complexed with ca
      3. 2011877Domain d1bjjc_: 1bjj C: [19532]
        complexed with ca
      4. 2011878Domain d1bjjd_: 1bjj D: [19533]
        complexed with ca
      5. 2011879Domain d1bjje_: 1bjj E: [19534]
        complexed with ca
      6. 2011880Domain d1bjjf_: 1bjj F: [19535]
        complexed with ca
    4. Domain for 1bk9:
    5. Domains for 1c1j:
      1. 2011881Domain d1c1ja_: 1c1j A: [70061]
        complexed with bog, cd
      2. 2011882Domain d1c1jb_: 1c1j B: [70062]
        complexed with bog, cd
      3. 2011883Domain d1c1jc_: 1c1j C: [70063]
        complexed with bog, cd
      4. 2011884Domain d1c1jd_: 1c1j D: [70064]
        complexed with bog, cd
    6. Domains for 1jia:
      1. 2011869Domain d1jiaa_: 1jia A: [19528]
        complexed with ca
      2. 2011870Domain d1jiab_: 1jia B: [19529]
        complexed with ca
    7. Domain for 1m8r:
    8. Domain for 1m8s:
    9. Domain for 1psj:
  12. 2011893Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
    monomeric Lys-49 phospholipase A2 homologue
    1. Domain for 1mc2:
    2. Domain for 1mg6:
  13. 2011896Indian cobra (Naja naja) [TaxId:35670] [48626] (3 PDB entries)
    1. Domain for 1a3d:
    2. Domains for 1a3f:
      1. 2011901Domain d1a3fa_: 1a3f A: [19521]
      2. 2011902Domain d1a3fb_: 1a3f B: [19522]
      3. 2011903Domain d1a3fc_: 1a3f C: [19523]
    3. Domains for 1psh:
      1. 2011898Domain d1psha_: 1psh A: [19518]
        complexed with ca
      2. 2011899Domain d1pshb_: 1psh B: [19519]
        complexed with ca
      3. 2011900Domain d1pshc_: 1psh C: [19520]
        complexed with ca
  14. 2011904Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    • Domain for 1ows:
      • 2011905Domain d1owsa_: 1ows A: [87491]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  15. 2011906Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    • Domain for 1ows:
      • 2011907Domain d1owsb_: 1ows B: [87492]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  16. 2011908Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (7 PDB entries)
    Uniprot Q6SLM1 # fragment; Uniprot Q9DF52 28-145 # ! 74% sequence identity
    1. Domain for 1dpy:
    2. Domain for 1fe5:
    3. Domains for 1g0z:
      1. 2011911Domain d1g0za_: 1g0z A: [83263]
        complexed with cl; mutant
      2. 2011912Domain d1g0zb_: 1g0z B: [83264]
        complexed with cl; mutant
    4. Domains for 1g2x:
      1. 2011914Domain d1g2xa_: 1g2x A: [83265]
        trimeric isoform
      2. 2011915Domain d1g2xb_: 1g2x B: [83266]
        trimeric isoform
      3. 2011916Domain d1g2xc_: 1g2x C: [83267]
        trimeric isoform
    5. Domain for 1po8:
    6. Domain for 1tc8:
    7. Domains for 1u4j:
      1. 2011909Domain d1u4ja_: 1u4j A: [107673]
        complexed with acy, cl, man, na
      2. 2011910Domain d1u4jb_: 1u4j B: [107674]
        complexed with acy, cl, man, na
  17. 2011920Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (9 PDB entries)
    Uniprot Q8AXY1 17-138
    1. Domains for 1u73:
      1. 2011926Domain d1u73a_: 1u73 A: [113075]
      2. 2011927Domain d1u73b_: 1u73 B: [113076]
    2. Domain for 1umv:
      • 2011922Domain d1umvx_: 1umv X: [99630]
        acidic, non-myotoxic phospholipase A2
        complexed with ca
    3. Domains for 3cxi:
      1. 2011924Domain d3cxia_: 3cxi A: [173528]
        automated match to d1pa0a_
        complexed with pe4, so4, vit
      2. 2011925Domain d3cxib_: 3cxi B: [173529]
        automated match to d1pa0a_
        complexed with pe4, so4, vit
    4. Domains for 3hzd:
      1. 2011928Domain d3hzda_: 3hzd A: [177960]
        automated match to d1pa0a_
        complexed with li
      2. 2011929Domain d3hzdb_: 3hzd B: [177961]
        automated match to d1pa0a_
        complexed with li
    5. Domains for 3hzw:
      1. 2011930Domain d3hzwa_: 3hzw A: [177972]
        automated match to d1pa0a_
        complexed with ipa, pbp
      2. 2011931Domain d3hzwb_: 3hzw B: [177973]
        automated match to d1pa0a_
        complexed with ipa, pbp
    6. Domain for 3i03:
    7. Domains for 3i3h:
      1. 2011932Domain d3i3ha_: 3i3h A: [178047]
        automated match to d1pa0a_
      2. 2011933Domain d3i3hb_: 3i3h B: [178048]
        automated match to d1pa0a_
    8. Domain for 3i3i:
    9. Domains for 4wtb:
      1. 2011934Domain d4wtba_: 4wtb A: [279354]
        automated match to d4k06a_
        complexed with cl, so4, zn
      2. 2011935Domain d4wtbb_: 4wtb B: [279355]
        automated match to d4k06a_
        complexed with cl, so4, zn
  18. 2011936King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
  19. 2011940King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
  20. 2011947Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
    neurotoxic phospholipase a2
  21. 2011950Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (2 PDB entries)
    presynaptic neurotoxic phospholipase A2
    1. Domain for 1ae7:
    2. Domain for 4e4c:
  22. 2011953Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
  23. 2011955Naja naja [311160] (1 PDB entry)
  24. 2011958Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (3 PDB entries)
    1. Domains for 1pa0:
      1. 2011959Domain d1pa0a_: 1pa0 A: [104097]
      2. 2011960Domain d1pa0b_: 1pa0 B: [104098]
    2. Domains for 1pc9:
      1. 2011963Domain d1pc9a_: 1pc9 A: [104107]
      2. 2011964Domain d1pc9b_: 1pc9 B: [104108]
    3. Domains for 3mlm:
      1. 2011961Domain d3mlma_: 3mlm A: [181389]
        automated match to d1pc9a_
        complexed with myr, so4
      2. 2011962Domain d3mlmb_: 3mlm B: [181390]
        automated match to d1pc9a_
        complexed with myr, so4
  25. 2011965Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
    anticoagulant class II phospholipase A2
  26. 2011967Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    1. Domain for 1aok:
      • 2011969Domain d1aokb_: 1aok B: [19561]
        complex with inhibitory subunit
        complexed with act
    2. Domain for 1jlt:
      • 2011968Domain d1jltb_: 1jlt B: [66868]
        complex with inhibitory subunit
        complexed with mpd, mrd
  27. 2011970Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (5 PDB entries)
    1. Domain for 1aok:
      • 2011973Domain d1aoka_: 1aok A: [19560]
        complex with catalytic subunit
        complexed with act
    2. Domain for 1jlt:
      • 2011971Domain d1jlta_: 1jlt A: [66867]
        complex with catalytic subunit
        complexed with mpd, mrd
    3. Domains for 1q5t:
      1. 2011974Domain d1q5ta_: 1q5t A: [95932]
        complexed with so4
      2. 2011975Domain d1q5tb_: 1q5t B: [95933]
        complexed with so4
    4. Domains for 1rgb:
      1. 2011976Domain d1rgba1: 1rgb A:1-133 [118769]
        automatically matched to d1vpi__
        complexed with eld
      2. 2011977Domain d1rgbb1: 1rgb B:1-133 [118770]
        automatically matched to d1vpi__
        complexed with eld
      3. 2011978Domain d1rgbk1: 1rgb K:1-133 [118771]
        automatically matched to d1vpi__
        complexed with eld
      4. 2011979Domain d1rgbl1: 1rgb L:1-133 [118772]
        automatically matched to d1vpi__
        complexed with eld
    5. Domain for 1vpi:
  28. 2011980Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
  29. 2011982Sharp-nosed viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
  30. 2011985Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
  31. 2011990Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
  32. 2011995Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries)
    Uniprot Q8JFB2 # 65% sequence identity
    1. Domains for 1ozy:
      1. 2012002Domain d1ozya_: 1ozy A: [104047]
        complexed with so4
      2. 2012003Domain d1ozyb_: 1ozy B: [104048]
        complexed with so4
    2. Domains for 1p7o:
      1. 2011996Domain d1p7oa_: 1p7o A: [104076]
      2. 2011997Domain d1p7ob_: 1p7o B: [104077]
      3. 2011998Domain d1p7oc_: 1p7o C: [104078]
      4. 2011999Domain d1p7od_: 1p7o D: [104079]
      5. 2012000Domain d1p7oe_: 1p7o E: [104080]
      6. 2012001Domain d1p7of_: 1p7o F: [104081]
  33. 2012004Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
    Uniprot Q9IAT9; Asp-49 phospholipase A2 homologue
  34. 2012007Snake (Daboia russellii pulchella), different isoforms [TaxId:97228] [48630] (38 PDB entries)
    Uniprot P59071
    1. Domains for 1cl5:
      1. 2012052Domain d1cl5a_: 1cl5 A: [19551]
        complexed with vitamin E
      2. 2012053Domain d1cl5b_: 1cl5 B: [19552]
        complexed with vitamin E
    2. Domains for 1fb2:
      1. 2012045Domain d1fb2a_: 1fb2 A: [59758]
      2. 2012046Domain d1fb2b_: 1fb2 B: [59759]
    3. Domains for 1fe7:
      1. 2012034Domain d1fe7a_: 1fe7 A: [302410]
        automated match to d1tk4a_
        complexed with acy, co3, vit
      2. 2012035Domain d1fe7b_: 1fe7 B: [302411]
        automated match to d1tk4a_
        complexed with acy, co3, vit
    4. Domains for 1fv0:
      1. 2012025Domain d1fv0a_: 1fv0 A: [70147]
        complexed with aristolochic acid
        complexed with 9ar, act, dio, gol, so4
      2. 2012026Domain d1fv0b_: 1fv0 B: [70148]
        complexed with aristolochic acid
        complexed with 9ar, act, dio, gol, so4
    5. Domains for 1jq8:
      1. 2012041Domain d1jq8a_: 1jq8 A: [77147]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy, so4
      2. 2012042Domain d1jq8b_: 1jq8 B: [77148]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy, so4
    6. Domains for 1jq9:
      1. 2012036Domain d1jq9a_: 1jq9 A: [77149]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy
      2. 2012037Domain d1jq9b_: 1jq9 B: [77150]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy
    7. Domains for 1kpm:
      1. 2012032Domain d1kpma_: 1kpm A: [72844]
        complexed with vitamin E
        complexed with acy, vit
      2. 2012033Domain d1kpmb_: 1kpm B: [72845]
        complexed with vitamin E
        complexed with acy, vit
    8. Domains for 1oxl:
      1. 2012030Domain d1oxla_: 1oxl A: [93702]
        complexed with co3, ida, so4
      2. 2012031Domain d1oxlb_: 1oxl B: [93703]
        complexed with co3, ida, so4
    9. Domains for 1oyf:
      1. 2012050Domain d1oyfa_: 1oyf A: [87595]
        complexed with acy, mhn, so4
      2. 2012051Domain d1oyfb_: 1oyf B: [87596]
        complexed with acy, mhn, so4
    10. Domain for 1q6v:
    11. Domain for 1q7a:
    12. Domain for 1skg:
    13. Domain for 1sqz:
    14. Domain for 1sv3:
    15. Domain for 1sv9:
    16. Domain for 1sxk:
    17. Domain for 1tdv:
    18. Domain for 1tg1:
    19. Domain for 1tg4:
    20. Domain for 1tgm:
    21. Domain for 1th6:
    22. Domain for 1ti0:
    23. Domain for 1tj9:
    24. Domain for 1tjk:
    25. Domain for 1tk4:
    26. Domains for 1tp2:
      1. 2012048Domain d1tp2a_: 1tp2 A: [107181]
        complexed with acy, so4, tda
      2. 2012049Domain d1tp2b_: 1tp2 B: [107182]
        complexed with acy, so4, tda
    27. Domain for 2dv8:
    28. Domain for 2gns:
    29. Domain for 3fo7:
    30. Domain for 3g8f:
    31. Domain for 4eix:
    32. Domain for 4hmb:
    33. Domain for 4qem:
    34. Domain for 4qer:
    35. Domain for 4qf7:
    36. Domain for 4qf8:
    37. Domain for 4qgd:
    38. Domain for 4qmc:
  35. 2012056Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    1. Domain for 1poa:
    2. Domains for 1pob:
      1. 2012058Domain d1poba_: 1pob A: [19515]
        complexed with ca, gel
      2. 2012059Domain d1pobb_: 1pob B: [19516]
        complexed with ca, gel
  36. 2012060Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (2 PDB entries)
    1. Domains for 1clp:
      1. 2012063Domain d1clpa_: 1clp A: [19615]
      2. 2012064Domain d1clpb_: 1clp B: [19616]
    2. Domains for 1y4l:
      1. 2012061Domain d1y4la_: 1y4l A: [122624]
        automated match to d1clpa_
        complexed with ipa, p33, svr
      2. 2012062Domain d1y4lb_: 1y4l B: [122625]
        automated match to d1clpa_
        complexed with ipa, p33, svr
  37. 2012065Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)
  38. 2299929Bothrops pauloensis [TaxId:1042543] [343230] (2 PDB entries)
    1. Domains for 5vfj:
      1. 2299930Domain d5vfjb1: 5vfj B:3-133 [343231]
        Other proteins in same PDB: d5vfja2, d5vfjb2
        automated match to d1pa0a_
        complexed with dhc, so4
      2. 2299950Domain d5vfja1: 5vfj A:3-133 [343251]
        Other proteins in same PDB: d5vfja2, d5vfjb2
        automated match to d1pa0a_
        complexed with dhc, so4
    2. Domains for 5vfm:
      1. 2299935Domain d5vfma1: 5vfm A:3-133 [343236]
        Other proteins in same PDB: d5vfma2, d5vfmb2
        automated match to d1pa0a_
        complexed with hc4, me2, so4
      2. 2299946Domain d5vfmb1: 5vfm B:3-133 [343247]
        Other proteins in same PDB: d5vfma2, d5vfmb2
        automated match to d1pa0a_
        complexed with hc4, me2, so4

More info for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2

Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2: