Lineage for Class a: All alpha proteins

  1. Root: SCOPe 2.08
  2. Class a: All alpha proteins [46456] (290 folds)

Folds:

  1. a.1: Globin-like [46457] (2 superfamilies)
    core: 6 helices; folded leaf, partly opened
  2. a.2: Long alpha-hairpin [46556] (20 superfamilies)
    2 helices; antiparallel hairpin, left-handed twist
  3. a.3: Cytochrome c [46625] (1 superfamily)
    core: 3 helices; folded leaf, opened
  4. a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  5. a.5: RuvA C-terminal domain-like [46928] (9 superfamilies)
    3 helices; bundle, right-handed twist
  6. a.6: Putative DNA-binding domain [46954] (1 superfamily)
    core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
  7. a.7: Spectrin repeat-like [46965] (16 superfamilies)
    3 helices; bundle, closed, left-handed twist; up-and-down
  8. a.8: immunoglobulin/albumin-binding domain-like [46996] (11 superfamilies)
    3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
  9. a.9: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1 superfamily)
    3 helices; bundle, closed, right-handed twist; up-and-down
  10. a.10: Protozoan pheromone-like [47013] (2 superfamilies)
    3 helices; bundle, closed, left-handed twist, up-and-down
  11. a.11: Acyl-CoA binding protein-like [47026] (2 superfamilies)
    core: 3 helices; bundle, closed, left-handed twist; up-and-down
  12. a.12: Kix domain of CBP (creb binding protein) [47039] (1 superfamily)
    3 helices; bundle, partly opened
  13. a.13: RAP domain-like [47044] (1 superfamily)
    3 helices, the first one is shorter than the other two; bundle, partly opened
  14. a.14: VHP, Villin headpiece domain [47049] (1 superfamily)
    3 short helices; irregular array
  15. a.15: TAF(II)230 TBP-binding fragment [47054] (1 superfamily)
    3 short helices; irregular array
  16. a.16: S15/NS1 RNA-binding domain [47059] (1 superfamily)
    3 helices; irregular array
  17. a.17: Cysteine alpha-hairpin motif [47071] (1 superfamily)
    core: alpha-hairpin crosslinked with two disulfides
  18. a.18: T4 endonuclease V [47076] (1 superfamily)
    3 helices; irregular array
  19. a.19: Fertilization protein [47081] (1 superfamily)
    core: 3 helices; bundle, closed, right-handed twist; up-and-down
  20. a.20: PGBD-like [47089] (1 superfamily)
    core: 3 helices; bundle, closed, left-handed twist; parallel
  21. a.21: HMG-box [47094] (1 superfamily)
    3 helices; irregular array
  22. a.22: Histone-fold [47112] (1 superfamily)
    core: 3 helices; long middle helix is flanked at each end with shorter ones
  23. a.23: Open three-helical up-and-down bundle [47143] (7 superfamilies)
    core: 3 helices; bundle, open
  24. a.24: Four-helical up-and-down bundle [47161] (29 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
  25. a.25: Ferritin-like [47239] (6 superfamilies)
    core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
  26. a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  27. a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily)
    core: 4 helices; bundle; one loop crosses over one side of the bundle
  28. a.28: Acyl carrier protein-like [47335] (3 superfamilies)
    4 helices, bundle; helix 3 is shorter than others; up-and-down
  29. a.29: Bromodomain-like [47363] (15 superfamilies)
    4 helices; bundle; minor mirror variant of up-and-down topology
  30. a.30: ROP-like [47379] (8 superfamilies)
    4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
  31. a.31: Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  32. a.32: Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  33. a.33: Ectatomin subunits [47400] (1 superfamily)
    4 helices; bundle, closed, left-handed twist
  34. a.34: Dimerisation interlock [47405] (4 superfamilies)
    4 helices; bundle, closed, right-handed twist
  35. a.35: lambda repressor-like DNA-binding domains [47412] (1 superfamily)
    core: 4 helices; folded leaf, closed
  36. a.36: Signal peptide-binding domain [47445] (1 superfamily)
    4 helices; orthogonal array
  37. a.37: A DNA-binding domain in eukaryotic transcription factors [47453] (1 superfamily)
    4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
  38. a.38: HLH-like [47458] (2 superfamilies)
    4-helices; bundle, closed, left-handed twist; 2 crossover connections
  39. a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  40. a.40: CH domain-like [47575] (3 superfamilies)
    core: 4 helices: bundle
  41. a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
    core: 4 helices: bundle; unusual topology
  42. a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  43. a.43: Ribbon-helix-helix [47597] (1 superfamily)
    core: 4 helices; array of 2 hairpins, opened
  44. a.45: GST C-terminal domain-like [47615] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
  45. a.46: Methionine synthase domain-like [47643] (3 superfamilies)
    4 helices; bundle, left-handed twist; right-handed superhelix
  46. a.47: STAT-like [47654] (6 superfamilies)
    4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
  47. a.48: N-cbl like [47667] (5 superfamilies)
    4 helices; bundle, left-handed twist; left-handed superhelix
  48. a.49: C-terminal domain of B transposition protein [47680] (1 superfamily)
    4 helices; irregular array
  49. a.50: Anaphylotoxins (complement system) [47685] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  50. a.51: Cytochrome c oxidase subunit h [47693] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  51. a.52: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1 superfamily)
    4 helices; folded leaf; right-handed superhelix
  52. a.53: p53 tetramerization domain [47718] (1 superfamily)
    core: 4 helices; bundle
  53. a.54: Domain of early E2A DNA-binding protein, ADDBP [47723] (1 superfamily)
    4 helices; bundle, partly opened
  54. a.55: IHF-like DNA-binding proteins [47728] (1 superfamily)
    core: 4 helices; bundle, partly opened, capped with a beta-sheet
  55. a.56: CO dehydrogenase ISP C-domain like [47740] (1 superfamily)
    core: 4 helices, bundle
  56. a.57: Protein HNS-dependent expression A; HdeA [47751] (1 superfamily)
    4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
  57. a.58: Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1 superfamily)
    4 helices; an orthogonal array
  58. a.59: PAH2 domain [47761] (1 superfamily)
    4 helices; open up-and-down bundle; binds alpha-helical peptides
  59. a.60: SAM domain-like [47768] (17 superfamilies)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  60. a.61: Retroviral matrix proteins [47835] (1 superfamily)
    4-5 helices; right-handed superhelix
  61. a.62: Hepatitis B viral capsid (hbcag) [47851] (1 superfamily)
    5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
  62. a.63: Apolipophorin-III [47856] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  63. a.64: Saposin-like [47861] (2 superfamilies)
    5 helices; folded leaf, closed
  64. a.65: Annexin [47873] (1 superfamily)
    5 helices; folded leaf, closed
  65. a.66: Transducin (alpha subunit), insertion domain [47894] (1 superfamily)
    5 helices; folded leaf
  66. a.68: Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1 superfamily)
    5 helices; irregular array; left-handed superhelix
  67. a.69: Left-handed superhelix [47916] (4 superfamilies)
    core: 4-5 helices; bundle; left-handed superhelix
  68. a.70: ATPD N-terminal domain-like [47927] (2 superfamilies)
    core: 5 helices; bundle
  69. a.71: ERP29 C domain-like [47932] (2 superfamilies)
    5 helices; bundle
  70. a.72: Functional domain of the splicing factor Prp18 [47937] (1 superfamily)
    core: 5 helices; bundle
  71. a.73: Retrovirus capsid protein, N-terminal core domain [47942] (1 superfamily)
    core: 5 helices; bundle
  72. a.74: Cyclin-like [47953] (1 superfamily)
    core: 5 helices; one helix is surrounded by the others
  73. a.75: Ribosomal protein S7 [47972] (1 superfamily)
    core: 5 helices; contains one more helix and a beta-hairpin outside the core
  74. a.76: Iron-dependent repressor protein, dimerization domain [47978] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  75. a.77: DEATH domain [47985] (1 superfamily)
    6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
  76. a.78: GntR ligand-binding domain-like [48007] (1 superfamily)
    core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
  77. a.79: NusB-like [48012] (1 superfamily)
    6 helices: bundle; one central helix is surrounded by 5 others
  78. a.80: post-AAA+ oligomerization domain-like [48018] (1 superfamily)
    core: 5 helices: bundle
  79. a.81: N-terminal domain of DnaB helicase [48023] (1 superfamily)
    6 helices: array
  80. a.83: Guanido kinase N-terminal domain [48033] (1 superfamily)
    irregular array of 6 short helices
  81. a.84: Scaffolding protein gpD of bacteriophage procapsid [48044] (1 superfamily)
    core: 6 helices; one central helix is surrounded by 5 others
  82. a.85: Hemocyanin, N-terminal domain [48049] (1 superfamily)
    6 helices; bundle; one central helix is surrounded by 5 others
  83. a.86: Di-copper centre-containing domain [48055] (1 superfamily)
    multihelical
  84. a.87: DBL homology domain (DH-domain) [48064] (1 superfamily)
    multihelical; core: 5-helical bundle
  85. a.88: LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1 superfamily)
    multihelical; contains compact array of 6 short helices
  86. a.89: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1 superfamily)
    multihelical bundle; contains buried central helix
  87. a.90: Transcription factor STAT-4 N-domain [48091] (1 superfamily)
    multihelical; can be divided into two subdomains
  88. a.91: Regulator of G-protein signaling, RGS [48096] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
    contains a 4-helical bundle with left-handed twist and up-and-down topology
  89. a.92: Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
    possible duplication: subdomains have similar topologies
  90. a.93: Heme-dependent peroxidases [48112] (1 superfamily)
    multihelical; consists of two all-alpha domains
  91. a.94: Ribosomal protein L19 (L19e) [48139] (1 superfamily)
    multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
  92. a.95: Influenza virus matrix protein M1 [48144] (1 superfamily)
    multihelical; consists of two different all-alpha subdomains, 4 helices each
  93. a.96: DNA-glycosylase [48149] (1 superfamily)
    multihelical; consists of two all-alpha domains
  94. a.97: An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1 superfamily)
    multihelical; consists of two all-alpha domains
  95. a.98: R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1 superfamily)
    multihelical consists of two all-alpha subdomains
    subdomain 1 (residues 10-100) is a 4-helical bundle
  96. a.99: Cryptochrome/photolyase FAD-binding domain [48172] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  97. a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
  98. a.101: Uteroglobin-like [48200] (1 superfamily)
    multihelical
  99. a.102: alpha/alpha toroid [48207] (6 superfamilies)
    multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
  100. a.103: Citrate synthase [48255] (1 superfamily)
    multihelical; consists of two all-alpha domains
  101. a.104: Cytochrome P450 [48263] (1 superfamily)
    multihelical
  102. a.108: Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1 superfamily)
    multihelical; intertwined tetramer
  103. a.109: Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1 superfamily)
    multihelical; intertwined trimer of identical 3-helical subunits
  104. a.110: Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1 superfamily)
    multihelical; consists of two all-alpha domains
  105. a.111: Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1 superfamily)
    multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
  106. a.113: DNA repair protein MutS, domain III [48333] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains
  107. a.114: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1 superfamily)
    multihelical; bundle of longer and shorter helices
  108. a.115: A virus capsid protein alpha-helical domain [48344] (1 superfamily)
    multihelical; three-helical bundle in the core is surrounded by non-conserved helices
  109. a.116: GTPase activation domain, GAP [48349] (1 superfamily)
    multihelical
  110. a.117: Ras GEF [48365] (1 superfamily)
    multihelical
  111. a.118: alpha-alpha superhelix [48370] (28 superfamilies)
    multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
  112. a.119: Lipoxigenase [48483] (1 superfamily)
    multihelical
    large nearly all-alpha domain
  113. a.120: gene 59 helicase assembly protein [48492] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  114. a.121: Tetracyclin repressor-like, C-terminal domain [48497] (1 superfamily)
    multihelical; interlocked (homo)dimer
  115. a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  116. a.124: Phospholipase C/P1 nuclease [48536] (1 superfamily)
    multihelical
  117. a.126: Serum albumin-like [48551] (1 superfamily)
    multihelical; one domain consists of two similar disulfide-linked subdomains
  118. a.127: L-aspartase-like [48556] (1 superfamily)
    multihelical, consists of three all-alpha domains
  119. a.128: Terpenoid synthases [48575] (1 superfamily)
    multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
  120. a.129: GroEL equatorial domain-like [48591] (1 superfamily)
    multihelical; 8 helices arranged in 2 parallel layers
  121. a.130: Chorismate mutase II [48599] (1 superfamily)
    multihelical; core: 6 helices, bundle
  122. a.131: Peridinin-chlorophyll protein [48607] (1 superfamily)
    multihelical: forms a boat-shaped protein shell around cofactors
  123. a.132: Heme oxygenase-like [48612] (1 superfamily)
    multihelical; bundle
  124. a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  125. a.134: Fungal elicitin [48646] (1 superfamily)
    5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
  126. a.135: Tetraspanin [48651] (1 superfamily)
    5 helices: irregular disulfide-linked array; form homodimer
  127. a.136: FinO-like [48656] (1 superfamily)
    6 helices: irregular non-globular array; also contains two small beta-hairpins
  128. a.137: Non-globular all-alpha subunits of globular proteins [48661] (14 superfamilies)
    not a true fold
    annotated by the SCOP(e) curators as 'not a true fold'
  129. a.138: Multiheme cytochromes [48694] (1 superfamily)
    variable number of helices and little beta structure; not a true fold
    annotated by the SCOP(e) curators as 'not a true fold'
  130. a.139: Type I dockerin domain [63445] (1 superfamily)
    tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
  131. a.140: LEM/SAP HeH motif [63450] (6 superfamilies)
    helix-extended loop-helix; parallel helices
  132. a.141: Frizzled cysteine-rich domain [63500] (1 superfamily)
    Core: 3 helices; irregular array; disulfide-rich
  133. a.142: PTS-regulatory domain, PRD [63519] (1 superfamily)
    core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
  134. a.143: RPB6/omega subunit-like [63561] (1 superfamily)
    core: 2 helices and adjacent loops
  135. a.144: PABP domain-like [63569] (2 superfamilies)
    4 helices; an orthogonal array
  136. a.145: Flagellar transcriptional activator FlhD [63591] (1 superfamily)
    multihelical; forms intertwined dimer of identical 5-helical subunits
  137. a.146: Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1 superfamily)
    multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
  138. a.147: Bcr-Abl oncoprotein oligomerization domain [69035] (1 superfamily)
    core: 4 long helices; bundle
  139. a.148: Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1 superfamily)
    5 helices; one helix is surrounded by the others
  140. a.149: RNase III domain-like [69064] (1 superfamily)
    core: 5 helices; one helix is surrounded by the others
  141. a.150: Anti-sigma factor AsiA [69069] (1 superfamily)
    core: 5 helices: orthogonal array
  142. a.151: Glutamyl tRNA-reductase dimerization domain [69074] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  143. a.152: AhpD-like [69117] (1 superfamily)
    multihelical; contains 4-helical bundle and 2-helical arm
  144. a.153: Nuclear receptor coactivator interlocking domain [69124] (1 superfamily)
    3 helices, non-globular array; forms interlocked heterodimers with its targets
  145. a.154: Variable surface antigen VlsE [74747] (1 superfamily)
    multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
  146. a.155: H-NS histone-like proteins [81274] (1 superfamily)
    multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
  147. a.156: S13-like H2TH domain [81297] (1 superfamily)
    core: 3-4 helices
  148. a.157: Skp1 dimerisation domain-like [81384] (1 superfamily)
    multihelical; interlocked heterodimer with F-box proteins
  149. a.158: F-box domain [81385] (1 superfamily)
    multihelical; interlocked heterodimer with the Skp1 dimerisation domain
  150. a.159: Another 3-helical bundle [81602] (5 superfamilies)
    topologically similar to the DNA/RNA-binding bundles; distinct packing
  151. a.160: PAP/OAS1 substrate-binding domain [81632] (1 superfamily)
    core: 5-helical bundle; up-and-down; right-handed twist
  152. a.161: beta-catenin-interacting protein ICAT [81729] (1 superfamily)
    core: 3 helices; irregular array
  153. a.162: Pre-protein crosslinking domain of SecA [81766] (1 superfamily)
    core: 4 helices: bundle; flanked by two short beta-hairpins
    duplication: consists of two structural repeats
  154. a.163: Crustacean CHH/MIH/GIH neurohormone [81777] (1 superfamily)
    4 helices; irregular array, disulfide-linked
  155. a.164: C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1 superfamily)
    4 helices; folded leaf; right-handed superhelix
  156. a.165: Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1 superfamily)
    4 helices; open up-and-down bundle; flexible N-terminal tail
  157. a.166: RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1 superfamily)
    multihelical; irregular array of long and short helices
  158. a.168: SopE-like GEF domain [81831] (1 superfamily)
    multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
  159. a.169: BEACH domain [81836] (1 superfamily)
    multihelical, complex architecture
  160. a.170: BRCA2 helical domain [81871] (1 superfamily)
    multihelical; contains a 3-helical bundle surrounded by several shorter helices
  161. a.171: BRCA2 tower domain [81877] (1 superfamily)
    multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
  162. a.172: Helical scaffold and wing domains of SecA [81885] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains
  163. a.173: Poly A polymerase C-terminal region-like [81890] (1 superfamily)
    multihelical; can be divided into three subdomains (neck, body and tail)
  164. a.174: Double Clp-N motif [81922] (1 superfamily)
    multihelical; array
  165. a.175: Orange carotenoid protein, N-terminal domain [81929] (1 superfamily)
    multihelical; array
  166. a.176: N-terminal domain of bifunctional PutA protein [81934] (1 superfamily)
    multihelical; array
  167. a.177: Sigma2 domain of RNA polymerase sigma factors [88945] (1 superfamily)
    multihelical; consists of a conserved 4-helical core and a variable insert subdomain
  168. a.178: Soluble domain of poliovirus core protein 3a [89042] (1 superfamily)
    4 helices; bundle, closed, right-handed twist
  169. a.179: Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1 superfamily)
    4 helices; bundle, right-handed twist; left-handed superhelix
  170. a.180: N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1 superfamily)
    4 helices; irregular array
  171. a.181: Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1 superfamily)
    5 helices: orthogonal array
  172. a.182: GatB/YqeY motif [89094] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
  173. a.183: Nop domain [89123] (1 superfamily)
    multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
  174. a.184: TorD-like [89154] (1 superfamily)
    multihelical; bundle
  175. a.185: Gametocyte protein Pfg27 [89161] (1 superfamily)
    multihelical; bundle
  176. a.186: KaiA/RbsU domain [101214] (1 superfamily)
    4 helices; bundle, right-handed twist; right-handed superhelix
  177. a.187: HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1 superfamily)
    4 helices; irregular array
  178. a.188: PWI domain [101232] (1 superfamily)
    4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
  179. a.189: XPC-binding domain-like [101237] (1 superfamily)
    4 helices; array
  180. a.190: Flavivirus capsid protein C [101256] (1 superfamily)
    core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
  181. a.191: Methenyltetrahydrofolate cyclohydrolase-like [101261] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  182. a.192: N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1 superfamily)
    6 helices: bundle; left-handed twist, up-and-down topology
  183. a.193: GRIP domain [101282] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  184. a.194: L27 domain [101287] (1 superfamily)
    6 helices, heterodimer of 3-helical domains
  185. a.195: YutG-like [101306] (1 superfamily)
    core: 6 helices; bundle; one central helix is surrounded by 5 others
  186. a.196: Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1 superfamily)
    6 helices: orthogonal array
  187. a.198: YcfC-like [101321] (1 superfamily)
    multihelical; contains two buried central helices
  188. a.199: YgfB-like [101326] (1 superfamily)
    multihelical; consists of two tightly associated 3-helical bundles with different twists
  189. a.200: Hypothetical protein MTH393 [101331] (1 superfamily)
    multihelical; consists of two all-alpha subdomains; dimer
  190. a.202: Superantigen MAM [101343] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  191. a.203: Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1 superfamily)
    multihelical; consists of two all-alpha subdomains
  192. a.204: all-alpha NTP pyrophosphatases [101385] (1 superfamily)
    multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
  193. a.205: Hsp90 co-chaperone CDC37 [101390] (1 superfamily)
    multihelical; consists of 2 all-alpha subdomains connected by a long helix
  194. a.206: P40 nucleoprotein [101398] (1 superfamily)
    multihelical; consists of two subdomains
  195. a.207: Formin homology 2 domain (FH2 domain) [101446] (1 superfamily)
    multihelical, consists of three all-alpha domains
  196. a.208: DhaL-like [101472] (1 superfamily)
    multihelical; bundle
  197. a.209: ADP-ribosylglycohydrolase [101477] (1 superfamily)
    multihelical; bundle
  198. a.210: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1 superfamily)
    5 helices, non-globular array; wraps around the N-terminal tail of its target
  199. a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  200. a.212: KRAB domain (Kruppel-associated box) [109639] (1 superfamily)
    2 helices: one short, one long; aromatic-rich iterface
  201. a.213: DinB/YfiT-like putative metalloenzymes [109853] (1 superfamily)
    core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
  202. a.214: NblA-like [109858] (1 superfamily)
    4 helices; dimer of identical alpha-hairpin subunits; open bundle
  203. a.215: A middle domain of Talin 1 [109879] (1 superfamily)
    5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (47161)
  204. a.216: I/LWEQ domain [109884] (1 superfamily)
    5 helices; bundle, closed, left-handed twist
  205. a.217: Surp module (SWAP domain) [109904] (1 superfamily)
    5 helices: irregular array
  206. a.218: YgfY-like [109909] (1 superfamily)
    5 helices; array; forms a tight dimer in crystals
  207. a.219: Hypothetical protein YhaI [109914] (1 superfamily)
    core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
  208. a.220: Hypothetical protein At3g22680 [109919] (1 superfamily)
    5 helices; array; probable biological unit is a homodimer
  209. a.221: Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1 superfamily)
    dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
  210. a.222: VPS9 domain [109992] (1 superfamily)
    multihelical; consist of two subdomains
  211. a.223: Triger factor/SurA peptide-binding domain-like [109997] (1 superfamily)
    multihelical; irregular array of long and short helices
  212. a.224: Glycolipid transfer protein, GLTP [110003] (1 superfamily)
    multihelical; 2 layers or orthogonally packed helices
  213. a.225: Hypothetical protein MG354 [110008] (1 superfamily)
    multihelical bundle; contains buried central helix
  214. a.226: Her-1 [110013] (1 superfamily)
    multihelical; consists of two topologically similar alpha-helical bundles
  215. a.227: ERO1-like [110018] (1 superfamily)
    multihelical; consists of 2 four-helical bundles
  216. a.228: GDNF receptor-like [110034] (1 superfamily)
    5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (48646)
  217. a.229: Hypothetical protein YqbG [116914] (1 superfamily)
    core: 4 helices; bundle, right-handed twist; left-handed superhelix
  218. a.230: YugE-like [116921] (1 superfamily)
    4-helices; bundle; right-handed twist
  219. a.231: EspA/CesA-like [116926] (1 superfamily)
    4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
  220. a.232: RNA-binding protein She2p [116941] (1 superfamily)
    5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (48556)
  221. a.233: YfbU-like [116959] (1 superfamily)
    multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
  222. a.234: Hypothetical protein MPN330 [116964] (1 superfamily)
    multihelical; consists of three different 4-helical bundles
  223. a.235: ATP-dependent DNA ligase DNA-binding domain [117017] (1 superfamily)
    multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
  224. a.236: DNA primase DnaG, C-terminal domain [117022] (1 superfamily)
    multihelical; segment-swapped dimer
  225. a.237: DNA polymerase III theta subunit-like [116730] (1 superfamily)
    3 helices; irregular array
  226. a.238: BAR/IMD domain-like [116747] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  227. a.239: ChaB-like [140375] (1 superfamily)
    3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
  228. a.240: BSD domain-like [140382] (1 superfamily)
    core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
  229. a.241: TraM-like [140580] (1 superfamily)
    multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
  230. a.242: Dcp2 domain-like [140585] (1 superfamily)
    4 helices; orthogonal array of two alpha hairpins
  231. a.243: Type III secretion system domain [140590] (1 superfamily)
    core: 4 helices, orthogonal array; right-handed superhelix
  232. a.244: EF2947-like [140606] (1 superfamily)
    4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
  233. a.245: EB1 dimerisation domain-like [140611] (1 superfamily)
    dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
  234. a.246: Hyaluronidase domain-like [140656] (3 superfamilies)
    5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
  235. a.247: YoaC-like [140669] (1 superfamily)
    5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (101214)
  236. a.248: SP0561-like [140682] (1 superfamily)
    5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
  237. a.249: YfmB-like [140687] (1 superfamily)
    5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (81593)
  238. a.250: IpaD-like [140692] (1 superfamily)
    6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
  239. a.251: Phage replication organizer domain [140712] (1 superfamily)
    6 helices, homodimer of 3-helical domains
  240. a.252: Mediator hinge subcomplex-like [140717] (1 superfamily)
    6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
  241. a.253: AF0941-like [140725] (1 superfamily)
    6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
  242. a.254: PA2201 C-terminal domain-like [140730] (1 superfamily)
    multihelical; seven-helical bundle with buried central helix
  243. a.255: Rv1873-like [140735] (1 superfamily)
    multihelical; contains unusually short buried central helix
  244. a.256: RUN domain-like [140740] (1 superfamily)
    multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
  245. a.257: SipA N-terminal domain-like [140745] (1 superfamily)
    multihelical; bundle; the last helix is buried inside the bundle
  246. a.258: PG0816-like [140752] (1 superfamily)
    multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (46928)
  247. a.259: YidB-like [140803] (1 superfamily)
    multihelical; three strings of short helices are packed across one longer helix
  248. a.260: Rhabdovirus nucleoprotein-like [140808] (1 superfamily)
    multihelical, consist of two helical domains; each domain contains a buried helix
  249. a.261: GUN4-like [140868] (1 superfamily)
    multihelical; open array, trapping inside an extended region before the C-terminal helix
  250. a.262: PriB N-terminal domain-like [140913] (1 superfamily)
    multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
  251. a.263: DNA terminal protein [140918] (1 superfamily)
    multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
  252. a.264: Duffy binding domain-like [140923] (1 superfamily)
    consist of two subdomains, each containing a three-helical bundle
  253. a.265: Fic-like [140930] (1 superfamily)
    multihelical; one central helix is surrounded by seven helices
  254. a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
    multihelical; bundle, contains interrupted helices
  255. a.267: Topoisomerase V catalytic domain-like [140978] (1 superfamily)
    multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (46688)
  256. a.268: PTPA-like [140983] (1 superfamily)
    multihelical
  257. a.269: FtsH protease domain-like [140989] (1 superfamily)
    array of 6 helices and a 2-stranded beta-ribbon
  258. a.270: Hermes dimerisation domain [140995] (1 superfamily)
    multihelical, intertwinned dimer of two 4-helical strings
  259. a.271: SOCS box-like [158234] (1 superfamily)
    helix-loop-helix motif with orthogonally packed helices
  260. a.272: YqgQ-like [158378] (1 superfamily)
    3 helices, bundle, left-handed twist, extended overside connection between the first and second helices
  261. a.273: Orange domain-like [158456] (1 superfamily)
    4 helices; dimer of identical alpha-hairpin subunits;
  262. a.274: HAMP domain-like [158471] (1 superfamily)
    dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections
  263. a.275: DnaD domain-like [158498] (1 superfamily)
    4 helices; bundle, right-handed twist; left-handed superhelix
  264. a.276: BH2638-like [158503] (1 superfamily)
    4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (81782)
  265. a.277: TAFH domain-like [158552] (1 superfamily)
    5 helices; folded leaf, closed
  266. a.278: GINS helical bundle-like [158572] (1 superfamily)
    5 helices, staggered bundle;
  267. a.279: Jann4075-like [158586] (1 superfamily)
    core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains
  268. a.280: RbcX-like [158614] (1 superfamily)
    5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer
  269. a.281: YheA-like [158621] (1 superfamily)
    5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces
  270. a.282: RPA2825-like [158633] (1 superfamily)
    5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (47089)
  271. a.283: ENT-like [158638] (1 superfamily)
    5 helices, irregular array, right-handed superhelix
  272. a.284: YejL-like [158650] (1 superfamily)
    6 helices; intertwined homodimer of three-helical subunits, bundle
  273. a.285: MtlR-like [158667] (1 superfamily)
    multihelical; 8-helical up-and-down bundle
  274. a.286: Sama2622-like [158674] (1 superfamily)
    core: 6 helices; bundle; one central helix is surrounded by 5 others
  275. a.287: TerB-like [158681] (1 superfamily)
    multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry
  276. a.288: UraD-like [158693] (1 superfamily)
    multihelical; irregular array of long and short helices
  277. a.289: Sec63 N-terminal domain-like [158701] (1 superfamily)
    multihelical; consists of two helical subdomains
  278. a.290: PSPTO4464-like [158709] (1 superfamily)
    multihelical; consists of two subdomains at the ends of a long connecting helix
  279. a.291: MG296-like [158714] (1 superfamily)
    multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix
  280. a.292: HP0242-like [158751] (1 superfamily)
    multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot
  281. a.293: SMc04008-like [158756] (1 superfamily)
    multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site
  282. a.294: Tex N-terminal region-like [158831] (1 superfamily)
    multihelical; irregular array of long and short helices; can be divided into several subdomains
  283. a.295: AGR_C_984p-like [158836] (1 superfamily)
    multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain
  284. a.296: PMT central region-like [158841] (1 superfamily)
    multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet
  285. a.297: DDB1 C-terminal-like [254113] (1 superfamily)
    5 helices in an irregular bundle. Slight similarity to SAM domains (a.60)
  286. a.298: Left-handed alpha-alpha superhelix [267589] (1 superfamily)
    multihelical; 2 (curved) layers: alpha/alpha; left-handed superhelix
  287. a.299: Tenuivirus/Phlebovirus nucleocapsid protein-like [310560] (1 superfamily)
  288. a.300: Arenavirus nucleocapsid protein-like [310566] (1 superfamily)
  289. a.301: Sus1-like [310571] (1 superfamily)
    5 helices; articulated hairpin fold
  290. a.302: Putative dsDNA-binding domain from CRISPR-associated protein Cas12a / Cpf1-like [418722] (1 superfamily)
    two layers, irregular array of helices
    Some structural similarity to lambda integrase (d.163.1.1) noted in PubMed 27096363

More info for Class a: All alpha proteins

Timeline for Class a: All alpha proteins: