Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOPe 2.08
  2. Class a: All alpha proteins [46456] (290 folds)
  3. Fold a.24: Four-helical up-and-down bundle [47161] (29 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. a.24.2: Aspartate receptor, ligand-binding domain [47170] (2 families) (S)
    automatically mapped to Pfam PF02203
  3. a.24.3: Cytochromes [47175] (3 families) (S)
    Heme-containing proteins
  4. a.24.4: Hemerythrin-like [47188] (1 family) (S)
  5. a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
    automatically mapped to Pfam PF00721
  6. a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
    automatically mapped to Pfam PF08771
  7. a.24.8: Proteasome activator [47216] (1 family) (S)
  8. a.24.9: alpha-catenin/vinculin-like [47220] (2 families) (S)
  9. a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (7 families) (S)
    contains additional, fifth helix at the N-terminus
  10. a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. a.24.12: Outer surface protein C (OspC) [63515] (2 families) (S)
  12. a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (2 families) (S)
  13. a.24.14: FAT domain of focal adhesion kinase [68993] (2 families) (S)
  14. a.24.15: FAD-dependent thiol oxidase [69000] (2 families) (S)
  15. a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (5 families) (S)
  16. a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
    automatically mapped to Pfam PF05757
  18. a.24.19: Flagellar export chaperone FliS [101116] (2 families) (S)
    can form closed, open and helix-swapped bundles
  19. a.24.20: Colicin D immunity protein [101125] (1 family) (S)
    automatically mapped to Pfam PF09204
  20. a.24.21: RecG, N-terminal domain [69008] (1 family) (S)
  21. a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family) (S)
    automatically mapped to Pfam PF09055
  22. a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family) (S)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
    automatically mapped to Pfam PF03036
  23. a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family) (S)
    automatically mapped to Pfam PF08910
  24. a.24.25: TrmE connector domain [116878] (1 family) (S)
  25. a.24.26: YppE-like [140415] (1 family) (S)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
    automatically mapped to Pfam PF08807
  26. a.24.27: MW0975(SA0943)-like [140423] (1 family) (S)
    open bundle; there is a long groove between helices 1 and 4
    automatically mapped to Pfam PF10368
  27. a.24.28: VPS28 C-terminal domain-like [140427] (2 families) (S)
  28. a.24.29: TM1646-like [158397] (2 families) (S)
    automatically mapped to Pfam PF03885
  29. a.24.30: Helical bundle domains from Csm1/Cmr1-like [418771] (2 families) (S)
    Domains follow the nucleotide cyclase domains, as described PubMed 22405013; may contain N-terminal kinked helix

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: