Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2312794Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. 2312795a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. 2312817a.24.2: Aspartate receptor, ligand-binding domain [47170] (2 families) (S)
    automatically mapped to Pfam PF02203
  3. 2312848a.24.3: Cytochromes [47175] (3 families) (S)
    Heme-containing proteins
  4. 2313254a.24.4: Hemerythrin-like [47188] (1 family) (S)
  5. 2313298a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
    automatically mapped to Pfam PF00721
  6. 2313347a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
    automatically mapped to Pfam PF08771
  7. 2313379a.24.8: Proteasome activator [47216] (1 family) (S)
  8. 2313443a.24.9: alpha-catenin/vinculin-like [47220] (2 families) (S)
  9. 2313536a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (7 families) (S)
    contains additional, fifth helix at the N-terminus
  10. 2313608a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. 2313626a.24.12: Outer surface protein C (OspC) [63515] (2 families) (S)
  12. 2313661a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (2 families) (S)
  13. 2313764a.24.14: FAT domain of focal adhesion kinase [68993] (2 families) (S)
  14. 2313808a.24.15: FAD-dependent thiol oxidase [69000] (2 families) (S)
  15. 2313855a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (5 families) (S)
  16. 2313928a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. 2313951a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
    automatically mapped to Pfam PF05757
  18. 2313956a.24.19: Flagellar export chaperone FliS [101116] (2 families) (S)
    can form closed, open and helix-swapped bundles
  19. 2313981a.24.20: Colicin D immunity protein [101125] (1 family) (S)
    automatically mapped to Pfam PF09204
  20. 2313990a.24.21: RecG, N-terminal domain [69008] (1 family) (S)
  21. 2313995a.24.22: Nickel-containing superoxide dismutase, NiSOD [109770] (1 family) (S)
    automatically mapped to Pfam PF09055
  22. 2314086a.24.23: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1 family) (S)
    contains extra alpha+beta subdomain formed by the N- and C-termini.
    automatically mapped to Pfam PF03036
  23. 2314091a.24.24: Domain from hypothetical 2610208m17rik protein [109779] (1 family) (S)
    automatically mapped to Pfam PF08910
  24. 2314096a.24.25: TrmE connector domain [116878] (1 family) (S)
  25. 2314102a.24.26: YppE-like [140415] (1 family) (S)
    flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
    automatically mapped to Pfam PF08807
  26. 2314115a.24.27: MW0975(SA0943)-like [140423] (1 family) (S)
    open bundle; there is a long groove between helices 1 and 4
    automatically mapped to Pfam PF10368
  27. 2314120a.24.28: VPS28 C-terminal domain-like [140427] (2 families) (S)
  28. 2314141a.24.29: TM1646-like [158397] (2 families) (S)
    automatically mapped to Pfam PF03885

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: