Lineage for Fold a.4: DNA/RNA-binding 3-helical bundle

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1981147Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down


  1. 1981148a.4.1: Homeodomain-like [46689] (20 families) (S)
    consists only of helices
  2. 1982136a.4.2: Methylated DNA-protein cysteine methyltransferase, C-terminal domain [46767] (2 families) (S)
    automatically mapped to Pfam PF01035
  3. 1982162a.4.3: ARID-like [46774] (2 families) (S)
    contains extra helices at both N- and C-termini
  4. 1982196a.4.5: "Winged helix" DNA-binding domain [46785] (85 families) (S)
    contains a small beta-sheet (wing)
  5. 1984099a.4.6: C-terminal effector domain of the bipartite response regulators [46894] (4 families) (S)
    binds to DNA and RNA polymerase; the N-terminal, receiver domain belongs to the CheY family
  6. 1984251a.4.7: Ribosomal protein L11, C-terminal domain [46906] (1 family) (S)
  7. 1984365a.4.8: Ribosomal protein S18 [46911] (1 family) (S)
  8. 1984442a.4.9: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 [46915] (1 family) (S)
  9. 1984450a.4.10: N-terminal Zn binding domain of HIV integrase [46919] (1 family) (S)
  10. 1984474a.4.11: RNA polymerase subunit RPB10 [46924] (1 family) (S)
    automatically mapped to Pfam PF01194
  11. 1984523a.4.12: TrpR-like [48295] (4 families) (S)
    contains an extra shared helix after the HTH motif
  12. 1984585a.4.13: Sigma3 and sigma4 domains of RNA polymerase sigma factors [88659] (4 families) (S)
  13. 1984711a.4.14: KorB DNA-binding domain-like [109709] (1 family) (S)
    contains HTH motif in the common core; also contains extra N-terminal helix and C-terminal subdomain of 4 helices (left-handed superhelix)
  14. 1984729a.4.15: Rps17e-like [116820] (1 family) (S)
    automatically mapped to Pfam PF00833

More info for Fold a.4: DNA/RNA-binding 3-helical bundle

Timeline for Fold a.4: DNA/RNA-binding 3-helical bundle: