SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class a: All alpha proteins

  1. Root: SCOP 1.55
  2. 2Class a: All alpha proteins [46456] (138 folds)

Folds:

  1. 3a.1: Globin-like [46457] (2 superfamilies)
  2. 811a.2: Long alpha-hairpin [46556] (11 superfamilies)
  3. 985a.3: Cytochrome c [46625] (1 superfamily)
  4. 1223a.4: DNA/RNA-binding 3-helical bundle [46688] (11 superfamilies)
  5. 1765a.5: RuvA C-terminal domain-like [46928] (6 superfamilies)
  6. 1817a.6: Putative DNA-binding domain [46954] (1 superfamily)
  7. 1840a.7: Spectrin repeat-like [46965] (6 superfamilies)
  8. 1903a.8: Bacterial immunoglobulin/albumin-binding domains [46996] (1 superfamily)
  9. 1923a.9: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1 superfamily)
  10. 1937a.10: Protozoan pheromone proteins [47013] (1 superfamily)
  11. 1956a.11: Acyl-CoA binding protein-like [47026] (2 superfamilies)
  12. 1978a.12: Kix domain of CBP (creb binding protein) [47039] (1 superfamily)
  13. 1984a.13: alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 [47044] (1 superfamily)
  14. 1991a.14: Thermostable subdomain from chicken villin headpiece [47049] (1 superfamily)
  15. 1998a.15: TAF(II)230 TBP-binding fragment [47054] (1 superfamily)
  16. 2004a.16: S15/NS1 RNA-binding domain [47059] (1 superfamily)
  17. 2033a.17: p8-MTCP1 [47071] (1 superfamily)
  18. 2040a.18: T4 endonuclease V [47076] (1 superfamily)
  19. 2050a.19: Fertilization protein [47081] (1 superfamily)
  20. 2069a.20: Zn2+ DD-carboxypeptidase, N-terminal domain [47089] (1 superfamily)
  21. 2075a.21: HMG-box [47094] (1 superfamily)
  22. 2110a.22: Histone-fold [47112] (1 superfamily)
  23. 2194a.23: Open three-helical up-and-down bundle [47143] (4 superfamilies)
  24. 2246a.24: Four-helical up-and-down bundle [47161] (11 superfamilies)
  25. 2448a.25: Ferritin-like [47239] (1 superfamily)
  26. 2641a.26: 4-helical cytokines [47265] (1 superfamily)
  27. 2808a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily)
  28. 2830a.28: Acyl carrier protein-like [47335] (3 superfamilies)
  29. 2887a.29: Bromodomain-like [47363] (2 superfamilies)
  30. 2917a.30: ROP-like [47379] (2 superfamilies)
  31. 2949a.31: Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit [47390] (1 superfamily)
  32. 2956a.32: Transcription factor IIA (TFIIA), N-terminal domain [47395] (1 superfamily)
  33. 2963a.33: Ectatomin, A & B chains [47400] (1 superfamily)
  34. 2970a.34: SinR repressor dimerisation domain-like [47405] (1 superfamily)
  35. 2993a.35: lambda repressor-like DNA-binding domains [47412] (1 superfamily)
  36. a.36: Signal peptide-binding domain [47445] (1 superfamily)
  37. 3144a.37: Binding domain of Skn-1 [47453] (1 superfamily)
  38. a.38: Helix-loop-helix DNA-binding domain [47458] (1 superfamily)
  39. 3180a.39: EF Hand-like [47472] (3 superfamilies)
  40. 3533a.40: Calponin-homology domain, CH-domain [47575] (1 superfamily)
  41. 3562a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
  42. 3574a.42: MDM2 [47591] (1 superfamily)
  43. 3582a.43: Met repressor-like [47597] (1 superfamily)
  44. 3663a.44: Disulphide-bond formation facilitator (DSBA), insertion domain [47609] (1 superfamily)
  45. 3694a.45: Glutathione S-transferases, C-terminal domain [47615] (1 superfamily)
  46. 3964a.46: Methionine synthase domain-like [47643] (2 superfamilies)
  47. 3984a.47: STAT-like [47654] (2 superfamilies)
  48. 4005a.48: N-cbl like [47667] (3 superfamilies)
  49. 4035a.49: C-terminal domain B transposition protein [47680] (1 superfamily)
  50. 4041a.50: Anaphylotoxins (complement system) [47685] (1 superfamily)
  51. 4053a.51: Cytochrome c oxidase subunit h [47693] (1 superfamily)
  52. 4068a.52: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1 superfamily)
  53. 4111a.53: p53 tetramerization domain [47718] (1 superfamily)
  54. 4174a.54: Domain of early E2A DNA-binding protein, ADDBP [47723] (1 superfamily)
  55. 4185a.55: Prokaryotic DNA-bending protein [47728] (1 superfamily)
  56. 4212a.56: CO dehydrogenase ISP C-domain like [47740] (1 superfamily)
  57. 4234a.57: Protein HNS-dependent expression A; HdeA [47751] (1 superfamily)
  58. 4248a.58: Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1 superfamily)
  59. 4255a.59: PAH2 domain [47761] (1 superfamily)
  60. 4264a.60: SAM domain-like [47768] (10 superfamilies)
  61. 4521a.61: Retroviral matrix proteins [47835] (1 superfamily)
  62. 4550a.62: Hepatitis B viral capsid (hbcag) [47851] (1 superfamily)
  63. 4559a.63: Apolipophorin-III [47856] (1 superfamily)
  64. 4565a.64: Saposin-like [47861] (2 superfamilies)
  65. 4582a.65: Annexin [47873] (1 superfamily)
  66. 4652a.66: Transducin (alpha subunit), insertion domain [47894] (1 superfamily)
  67. 4694a.67: Thermolysin-like metalloproteases, C-terminal domain [47900] (1 superfamily)
  68. 4743a.68: Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1 superfamily)
  69. 4749a.69: Left-handed superhelix [47916] (2 superfamilies)
  70. 4808a.70: N-terminal domain of the delta subunit of the F1F0-ATP synthase [47927] (1 superfamily)
  71. 4814a.71: Endoplasmic reticulum protein ERP29, C-domain [47932] (1 superfamily)
  72. 4820a.72: Functional domain of the splicing factor Prp18 [47937] (1 superfamily)
  73. 4827a.73: Retrovirus capsid protein, N-terminal core domain [47942] (1 superfamily)
  74. 4853a.74: Cyclin-like [47953] (1 superfamily)
  75. 4927a.75: Ribosomal protein S7 [47972] (1 superfamily)
  76. 4941a.76: Iron-dependent represor protein, dimerization domain [47978] (1 superfamily)
  77. 4971a.77: DEATH domain [47985] (1 superfamily)
  78. 5012a.78: Fatty acid responsive transcription factor FadR, C-terminal domain [48007] (1 superfamily)
  79. 5022a.79: Antitermination factor NusB [48012] (1 superfamily)
  80. 5032a.80: delta prime subunit of DNA polymerase III, C-domain [48018] (1 superfamily)
  81. 5038a.81: N-terminal domain of DnaB helicase [48023] (1 superfamily)
  82. 5048a.82: FliG C-terminal domain [48028] (1 superfamily)
  83. 5055a.83: Guanido kinases [48033] (1 superfamily)
  84. 5085a.84: Scaffolding protein gpD of bacteriophage procapsid [48044] (1 superfamily)
  85. 5098a.85: Hemocyanin, N-terminal domain [48049] (1 superfamily)
  86. 5115a.86: Di-copper centre-containing domain [48055] (1 superfamily)
  87. 5142a.87: DBL homology domain [48064] (1 superfamily)
  88. 5160a.88: LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1 superfamily)
  89. 5169a.89: Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1 superfamily)
  90. 5192a.90: Transcription factor STAT-4 N-domain [48091] (1 superfamily)
  91. 5198a.91: Regulator of G-protein signalling, RGS [48096] (1 superfamily)
  92. 5221a.92: Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1 superfamily)
  93. 5254a.93: Heme-dependent peroxidases [48112] (1 superfamily)
  94. 5443a.94: Ribosomal protein L19 (L19e) [48139] (1 superfamily)
  95. 5449a.95: Influenza virus matrix protein M1 [48144] (1 superfamily)
  96. 5456a.96: DNA-glycosylase [48149] (1 superfamily)
  97. 5478a.97: Anticodon-binding (C-terminal) domain of glutamyl-tRNA synthetase (GluRS) [48162] (1 superfamily)
  98. 5484a.98: R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1 superfamily)
  99. 5511a.99: FAD-binding (C-terminal) domain of DNA photolyase [48172] (1 superfamily)
  100. 5520a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
  101. 5577a.101: Uteroglobin-like [48200] (1 superfamily)
  102. 5590a.102: alpha/alpha toroid [48207] (4 superfamilies)
  103. 5699a.103: Citrate synthase [48255] (1 superfamily)
  104. 5730a.104: Cytochrome P450 [48263] (1 superfamily)
  105. 5824a.105: FIS-like [48282] (1 superfamily)
  106. 5859a.106: Pleiotropic regulator of virulence genes, SarA [48289] (1 superfamily)
  107. 5867a.107: Trp repressor [48294] (1 superfamily)
  108. a.108: Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1 superfamily)
  109. 5907a.109: MHC class II-associated invariant chain ectoplasmic trimerization domain [48304] (1 superfamily)
  110. 5915a.110: Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1 superfamily)
  111. 5932a.111: Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1 superfamily)
  112. 5960a.112: sigma70 subunit fragment from RNA polymerase [48328] (1 superfamily)
  113. 5966a.113: DNA repair protein MutS, domain III [48333] (1 superfamily)
  114. 5980a.114: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1 superfamily)
  115. 5987a.115: Bluetongue virus coat protein vp7 (BTV-10 vp7), alpha-helical domain [48344] (1 superfamily)
  116. 6011a.116: GTPase activation domain, GAP [48349] (1 superfamily)
  117. 6040a.117: Ras GEF [48365] (1 superfamily)
  118. 6046a.118: alpha-alpha superhelix [48370] (11 superfamilies)
  119. 6281a.119: Lipoxigenase [48483] (1 superfamily)
  120. 6295a.120: gene 59 helicase assembly protein [48492] (1 superfamily)
  121. 6301a.121: Tetracyclin repressor (Tet-repressor, TetR), C-terminal domain [48497] (1 superfamily)
  122. 6316a.122: Skp1-Skp2 dimerisation domains [48502] (1 superfamily)
  123. 6345a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
  124. 6439a.124: Phospholipase C/P1 nuclease [48536] (1 superfamily)
  125. 6456a.125: Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48546] (1 superfamily)
  126. 6463a.126: Serum albumin [48551] (1 superfamily)
  127. 6519a.127: L-aspartase-like [48556] (1 superfamily)
  128. 6574a.128: Terpenoid synthases [48575] (1 superfamily)
  129. 6607a.129: GroEL-like chaperones, ATPase domain [48591] (1 superfamily)
  130. 6655a.130: Chorismate mutase II [48599] (1 superfamily)
  131. 6673a.131: Peridinin-chlorophyll protein [48607] (1 superfamily)
  132. 6684a.132: Heme oxygenase-1 (HO-1) [48612] (1 superfamily)
  133. 6695a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
  134. 6828a.134: Fungal elicitin, plant patogen [48646] (1 superfamily)
  135. 6836a.135: Tetraspanin [48651] (1 superfamily)
  136. 6843a.136: Repressor of bacterial conjugation FinO [48656] (1 superfamily)
  137. 6849a.137: Non-globular all-alpha subunits of globular proteins [48661] (8 superfamilies)
  138. 6906a.138: Multiheme cytochromes [48694] (1 superfamily)

More info for Class a: All alpha proteins

Timeline for Class a: All alpha proteins: