SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold a.60: SAM domain-like

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1998615Fold a.60: SAM domain-like [47768] (16 superfamilies)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

Superfamilies:

  1. 1998616a.60.1: SAM/Pointed domain [47769] (4 families) (S)
  2. 1998807a.60.2: RuvA domain 2-like [47781] (7 families) (S)
    duplication: contains two helix-hairpin-helix (HhH) motifs
  3. 1998907a.60.3: C-terminal domain of RNA polymerase alpha subunit [47789] (1 family) (S)
    contains one classic and one pseudo HhH motifs
  4. 1998937a.60.4: Rad51 N-terminal domain-like [47794] (4 families) (S)
    contains one classic and one pseudo HhH motifs
  5. 1998995a.60.5: Barrier-to-autointegration factor, BAF [47798] (1 family) (S)
    contains one classic and one pseudo HhH motifs
    automatically mapped to Pfam PF02961
  6. 1999012a.60.6: DNA polymerase beta, N-terminal domain-like [47802] (2 families) (S)
    contains one classic and one pseudo HhH motifs
  7. 1999281a.60.7: 5' to 3' exonuclease, C-terminal subdomain [47807] (2 families) (S)
  8. 1999332a.60.8: HRDC-like [47819] (5 families) (S)
  9. 1999381a.60.9: lambda integrase-like, N-terminal domain [47823] (2 families) (S)
  10. 1999457a.60.10: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain [47831] (1 family) (S)
  11. 1999473a.60.11: Hypothetical protein YjbJ [69047] (2 families) (S)
    automatically mapped to Pfam PF05532
  12. 1999483a.60.12: PsbU/PolX domain-like [81585] (3 families) (S)
    contains one classic and one pseudo HhH motifs
  13. 1999778a.60.13: Putative methyltransferase TM0872, insert domain [81799] (1 family) (S)
  14. 1999789a.60.14: eIF2alpha middle domain-like [116742] (2 families) (S)
  15. 1999808a.60.15: YozE-like [140652] (1 family) (S)
  16. 1999817a.60.16: GspK insert domain-like [158544] (1 family) (S)
    tandem repeat of two SAM-like domains iserted into pilin fold; domain 1 contains one classic HhH motif

More info for Fold a.60: SAM domain-like

Timeline for Fold a.60: SAM domain-like: