Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2335122Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2335123Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2335124Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)
  6. 2335233Protein Estrogen receptor alpha [48519] (1 species)
  7. 2335234Species Human (Homo sapiens) [TaxId:9606] [48520] (71 PDB entries)
    Uniprot P03372 307-551

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1a52:
    1. 2335324Domain d1a52a_: 1a52 A: [19296]
      complexed with au, est
    2. 2335325Domain d1a52b_: 1a52 B: [19297]
      complexed with au, est
  2. Domain(s) for 1ere:
    1. 2335356Domain d1erea_: 1ere A: [19300]
      complexed with est
    2. 2335357Domain d1ereb_: 1ere B: [19301]
      complexed with est
    3. 2335358Domain d1erec_: 1ere C: [19302]
      complexed with est
    4. 2335359Domain d1ered_: 1ere D: [19303]
      complexed with est
    5. 2335360Domain d1eree_: 1ere E: [19304]
      complexed with est
    6. 2335361Domain d1eref_: 1ere F: [19305]
      complexed with est
  3. Domain(s) for 1err:
    1. 2335326Domain d1erra_: 1err A: [19298]
      complexed with ral
    2. 2335327Domain d1errb_: 1err B: [19299]
      complexed with ral
  4. Domain(s) for 1g50:
    1. 2335362Domain d1g50a_: 1g50 A: [65149]
      complexed with est
    2. 2335363Domain d1g50b_: 1g50 B: [65150]
      complexed with est
    3. 2335364Domain d1g50c_: 1g50 C: [65151]
      complexed with est
  5. Domain(s) for 1gwq:
    1. 2335304Domain d1gwqa_: 1gwq A: [76366]
      complex with raloxifene core and TIF2 NRbox2 peptide; chains C and D
      protein/DNA complex; complexed with ztw
    2. 2335305Domain d1gwqb_: 1gwq B: [76367]
      complex with raloxifene core and TIF2 NRbox2 peptide; chains C and D
      protein/DNA complex; complexed with ztw
  6. Domain(s) for 1gwr:
    1. 2335308Domain d1gwra_: 1gwr A: [76368]
      complex with 17beta-oestradiol and TIF2 NRbox3 peptide; chains C and D
      protein/DNA complex; complexed with est
    2. 2335309Domain d1gwrb_: 1gwr B: [76369]
      complex with 17beta-oestradiol and TIF2 NRbox3 peptide; chains C and D
      protein/DNA complex; complexed with est
  7. Domain(s) for 1l2i:
    1. 2335241Domain d1l2ia_: 1l2i A: [73503]
      complexed with cl, etc
    2. 2335242Domain d1l2ib_: 1l2i B: [73504]
      complexed with cl, etc
  8. Domain(s) for 1pcg:
    1. 2335318Domain d1pcga_: 1pcg A: [94432]
      complexed with est
    2. 2335319Domain d1pcgb_: 1pcg B: [94433]
      complexed with est
  9. Domain(s) for 1qkt:
    • 2335283Domain d1qkta_: 1qkt A: [19295]
      complex with estradiol
      complexed with est; mutant
  10. Domain(s) for 1qku:
    1. 2335365Domain d1qkua_: 1qku A: [19306]
      complex with estradiol
      complexed with est
    2. 2335366Domain d1qkub_: 1qku B: [19307]
      complex with estradiol
      complexed with est
    3. 2335367Domain d1qkuc_: 1qku C: [19308]
      complex with estradiol
      complexed with est
  11. Domain(s) for 1r5k:
    1. 2335340Domain d1r5ka_: 1r5k A: [111706]
      protein/DNA complex; complexed with gw5
    2. 2335341Domain d1r5kb_: 1r5k B: [111707]
      protein/DNA complex; complexed with gw5
    3. 2335342Domain d1r5kc_: 1r5k C: [111708]
      protein/DNA complex; complexed with gw5
  12. Domain(s) for 1sj0:
  13. Domain(s) for 1uom:
  14. Domain(s) for 1x7e:
    1. 2335344Domain d1x7ea_: 1x7e A: [162037]
      automated match to d1g50a_
      complexed with 244
    2. 2335345Domain d1x7eb_: 1x7e B: [162038]
      automated match to d1g50a_
      complexed with 244
  15. Domain(s) for 1x7r:
  16. Domain(s) for 1xp1:
  17. Domain(s) for 1xp6:
  18. Domain(s) for 1xp9:
  19. Domain(s) for 1xpc:
  20. Domain(s) for 1yim:
  21. Domain(s) for 1yin:
  22. Domain(s) for 1zky:
    1. 2335275Domain d1zkya_: 1zky A: [162506]
      automated match to d1qkua_
      complexed with 689
    2. 2335276Domain d1zkyb_: 1zky B: [162507]
      automated match to d1qkua_
      complexed with 689
  23. Domain(s) for 2ayr:
  24. Domain(s) for 2b1v:
    1. 2335238Domain d2b1va_: 2b1v A: [162967]
      automated match to d1qkua_
      complexed with 458
    2. 2335239Domain d2b1vb_: 2b1v B: [162968]
      automated match to d1qkua_
      complexed with 458
  25. Domain(s) for 2b1z:
    1. 2335236Domain d2b1za_: 2b1z A: [162969]
      automated match to d1qkua_
      complexed with 17m
    2. 2335237Domain d2b1zb_: 2b1z B: [162970]
      automated match to d1qkua_
      complexed with 17m
  26. Domain(s) for 2b23:
    1. 2335277Domain d2b23a_: 2b23 A: [162971]
      automated match to d1qkua_
    2. 2335278Domain d2b23b_: 2b23 B: [162972]
      automated match to d1qkua_
  27. Domain(s) for 2ert:
  28. Domain(s) for 2fai:
    1. 2335268Domain d2faia_: 2fai A: [164311]
      automated match to d1qkua_
      complexed with 459
    2. 2335269Domain d2faib_: 2fai B: [164312]
      automated match to d1qkua_
      complexed with 459
  29. Domain(s) for 2g44:
    1. 2335322Domain d2g44a_: 2g44 A: [164578]
      automated match to d1qkua_
      complexed with t3o
    2. 2335323Domain d2g44b_: 2g44 B: [164579]
      automated match to d1qkua_
      complexed with t3o
  30. Domain(s) for 2g5o:
    1. 2335297Domain d2g5oa_: 2g5o A: [164583]
      automated match to d1qkua_
      complexed with drq
    2. 2335298Domain d2g5ob_: 2g5o B: [164584]
      automated match to d1qkua_
      complexed with drq
  31. Domain(s) for 2i0j:
    1. 2335374Domain d2i0ja_: 2i0j A: [165352]
      automated match to d1pcga_
      complexed with i0g
    2. 2335375Domain d2i0jb_: 2i0j B: [165353]
      automated match to d1pcga_
      complexed with i0g
    3. 2335376Domain d2i0jc_: 2i0j C: [165354]
      automated match to d1pcga_
      complexed with i0g
    4. 2335377Domain d2i0jd_: 2i0j D: [165355]
      automated match to d1pcga_
      complexed with i0g
  32. Domain(s) for 2iog:
  33. Domain(s) for 2iok:
    1. 2335338Domain d2ioka_: 2iok A: [147747]
      automated match to d1qkua_
      complexed with iok
    2. 2335339Domain d2iokb_: 2iok B: [147748]
      automated match to d1qkua_
      complexed with iok
  34. Domain(s) for 2ocf:
  35. Domain(s) for 2ouz:
  36. Domain(s) for 2p15:
    1. 2335299Domain d2p15a_: 2p15 A: [166933]
      automated match to d1qkua_
      complexed with ezt
    2. 2335300Domain d2p15b_: 2p15 B: [166934]
      automated match to d1qkua_
      complexed with ezt
  37. Domain(s) for 2pog:
    1. 2335284Domain d2poga_: 2pog A: [149721]
      automated match to d1qkta_
      complexed with wst
    2. 2335285Domain d2pogb_: 2pog B: [161507]
      automated match to d1qkta_
      complexed with wst
  38. Domain(s) for 2q6j:
    1. 2335372Domain d2q6ja_: 2q6j A: [167457]
      automated match to d1qkua_
      complexed with a48
    2. 2335373Domain d2q6jb_: 2q6j B: [167458]
      automated match to d1qkua_
      complexed with a48
  39. Domain(s) for 2q70:
    1. 2335272Domain d2q70a_: 2q70 A: [150072]
      automated match to d1qkta_
      complexed with dc8
    2. 2335273Domain d2q70b_: 2q70 B: [161524]
      automated match to d1qkta_
      complexed with dc8
  40. Domain(s) for 2qa6:
    1. 2335368Domain d2qa6a_: 2qa6 A: [167488]
      automated match to d1qkua_
      complexed with kn2; mutant
    2. 2335369Domain d2qa6b_: 2qa6 B: [167489]
      automated match to d1qkua_
      complexed with kn2; mutant
  41. Domain(s) for 2qa8:
    1. 2335243Domain d2qa8a_: 2qa8 A: [167490]
      automated match to d1qkua_
      complexed with gen; mutant
    2. 2335244Domain d2qa8b_: 2qa8 B: [167491]
      automated match to d1qkua_
      complexed with gen; mutant
  42. Domain(s) for 2qab:
    1. 2335295Domain d2qaba_: 2qab A: [167492]
      automated match to d1qkua_
      complexed with ei1; mutant
    2. 2335296Domain d2qabb_: 2qab B: [167493]
      automated match to d1qkua_
      complexed with ei1; mutant
  43. Domain(s) for 2qe4:
    1. 2335314Domain d2qe4a_: 2qe4 A: [167557]
      automated match to d1qkta_
      protein/DNA complex; complexed with jj3
    2. 2335315Domain d2qe4b_: 2qe4 B: [167558]
      automated match to d1qkta_
      protein/DNA complex; complexed with jj3
  44. Domain(s) for 2qgt:
    1. 2335320Domain d2qgta_: 2qgt A: [167573]
      automated match to d1qkua_
      complexed with eed
    2. 2335321Domain d2qgtb_: 2qgt B: [167574]
      automated match to d1qkua_
      complexed with eed
  45. Domain(s) for 2qgw:
    1. 2335350Domain d2qgwa_: 2qgw A: [167585]
      automated match to d1qkua_
      complexed with ees
    2. 2335351Domain d2qgwb_: 2qgw B: [167586]
      automated match to d1qkua_
      complexed with ees
  46. Domain(s) for 2qh6:
    1. 2335370Domain d2qh6a_: 2qh6 A: [167591]
      automated match to d1qkua_
      complexed with ode
    2. 2335371Domain d2qh6b_: 2qh6 B: [167592]
      automated match to d1qkua_
      complexed with ode
  47. Domain(s) for 2qr9:
    1. 2335306Domain d2qr9a_: 2qr9 A: [167777]
      automated match to d1qkua_
      protein/DNA complex; complexed with hz3
    2. 2335307Domain d2qr9b_: 2qr9 B: [167778]
      automated match to d1qkua_
      protein/DNA complex; complexed with hz3
  48. Domain(s) for 2qse:
    1. 2335288Domain d2qsea_: 2qse A: [167792]
      automated match to d1qkua_
      protein/DNA complex; complexed with 1hp
    2. 2335289Domain d2qseb_: 2qse B: [167793]
      automated match to d1qkua_
      protein/DNA complex; complexed with 1hp
  49. Domain(s) for 2qxm:
    1. 2335346Domain d2qxma_: 2qxm A: [167870]
      automated match to d1qkua_
      protein/DNA complex; complexed with piq
    2. 2335347Domain d2qxmb_: 2qxm B: [167871]
      automated match to d1qkua_
      protein/DNA complex; complexed with piq
  50. Domain(s) for 2qxs:
    1. 2335262Domain d2qxsa_: 2qxs A: [167872]
      automated match to d1qkua_
      protein/DNA complex; complexed with ral; mutant
    2. 2335263Domain d2qxsb_: 2qxs B: [167873]
      automated match to d1qkua_
      protein/DNA complex; complexed with ral; mutant
  51. Domain(s) for 2qzo:
    1. 2335270Domain d2qzoa_: 2qzo A: [167892]
      automated match to d1qkua_
      protein/DNA complex; complexed with kn1
    2. 2335271Domain d2qzob_: 2qzo B: [167893]
      automated match to d1qkua_
      protein/DNA complex; complexed with kn1
  52. Domain(s) for 2r6w:
    1. 2335253Domain d2r6wa_: 2r6w A: [151621]
      automated match to d1qkta_
      protein/DNA complex; complexed with llb
    2. 2335254Domain d2r6wb_: 2r6w B: [151622]
      automated match to d1qkta_
      protein/DNA complex; complexed with llb
  53. Domain(s) for 2r6y:
    1. 2335251Domain d2r6ya_: 2r6y A: [151623]
      automated match to d1qkta_
      protein/DNA complex; complexed with llc
    2. 2335252Domain d2r6yb_: 2r6y B: [151624]
      automated match to d1qkta_
      protein/DNA complex; complexed with llc
  54. Domain(s) for 2yja:
  55. Domain(s) for 3dt3:
    1. 2335348Domain d3dt3a_: 3dt3 A: [157848]
      automated match to d1qkua_
      complexed with 369
    2. 2335349Domain d3dt3b_: 3dt3 B: [157849]
      automated match to d1qkua_
      complexed with 369
  56. Domain(s) for 3erd:
    1. 2335260Domain d3erda_: 3erd A: [19293]
      complex with diethylstilbestrol and a peptide
      complexed with acy, cl, des
    2. 2335261Domain d3erdb_: 3erd B: [19294]
      complex with diethylstilbestrol and a peptide
      complexed with acy, cl, des
  57. Domain(s) for 3ert:
    • 2335258Domain d3erta_: 3ert A: [19292]
      complex with 4-hydroxytamoxifen
      complexed with oht
  58. Domain(s) for 3os8:
    1. 2335245Domain d3os8a_: 3os8 A: [183253]
      automated match to d1qkua_
      complexed with kn0
    2. 2335246Domain d3os8b_: 3os8 B: [183254]
      automated match to d1qkua_
      complexed with kn0
    3. 2335247Domain d3os8c_: 3os8 C: [183255]
      automated match to d1qkua_
      complexed with kn0
    4. 2335248Domain d3os8d_: 3os8 D: [183256]
      automated match to d1qkua_
      complexed with kn0
  59. Domain(s) for 3os9:
    1. 2335279Domain d3os9a_: 3os9 A: [183257]
      automated match to d1qkua_
      complexed with kn1
    2. 2335280Domain d3os9b_: 3os9 B: [183258]
      automated match to d1qkua_
      complexed with kn1
    3. 2335281Domain d3os9c_: 3os9 C: [183259]
      automated match to d1qkua_
      complexed with kn1
    4. 2335282Domain d3os9d_: 3os9 D: [183260]
      automated match to d1qkua_
      complexed with kn1
  60. Domain(s) for 3osa:
    1. 2335290Domain d3osaa_: 3osa A: [183261]
      automated match to d1qkua_
      complexed with kn3
    2. 2335291Domain d3osab_: 3osa B: [183262]
      automated match to d1qkua_
      complexed with kn3
    3. 2335292Domain d3osac_: 3osa C: [183263]
      automated match to d1qkua_
      complexed with kn3
    4. 2335293Domain d3osad_: 3osa D: [183264]
      automated match to d1qkua_
      complexed with kn3
  61. Domain(s) for 3uuc:
    1. 2335264Domain d3uuca_: 3uuc A: [194773]
      automated match to d3q95b_
      complexed with 0d1
    2. 2335265Domain d3uucb_: 3uuc B: [194775]
      automated match to d3q95b_
      complexed with 0d1
    3. 2335266Domain d3uucc_: 3uuc C: [194772]
      automated match to d3q95b_
      complexed with 0d1
    4. 2335267Domain d3uucd_: 3uuc D: [194774]
      automated match to d3q95b_
      complexed with 0d1
  62. Domain(s) for 4q50:
    1. 2335379Domain d4q50a_: 4q50 A: [271429]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    2. 2335380Domain d4q50b_: 4q50 B: [271433]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    3. 2335381Domain d4q50c_: 4q50 C: [271427]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    4. 2335382Domain d4q50d_: 4q50 D: [271428]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    5. 2335383Domain d4q50e_: 4q50 E: [271432]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    6. 2335384Domain d4q50f_: 4q50 F: [271434]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    7. 2335385Domain d4q50g_: 4q50 G: [271430]
      automated match to d3q95b_
      complexed with oht, so4; mutant
    8. 2335386Domain d4q50h_: 4q50 H: [271431]
      automated match to d3q95b_
      complexed with oht, so4; mutant
  63. Domain(s) for 4xi3:
    1. 2335352Domain d4xi3a_: 4xi3 A: [280507]
      automated match to d2qxsb_
      complexed with 29s
    2. 2335353Domain d4xi3b_: 4xi3 B: [280506]
      automated match to d2qxsb_
      complexed with 29s
    3. 2335354Domain d4xi3c_: 4xi3 C: [280508]
      automated match to d2qxsb_
      complexed with 29s
    4. 2335355Domain d4xi3d_: 4xi3 D: [280509]
      automated match to d2qxsb_
      complexed with 29s
  64. Domain(s) for 5jmm:
    1. 2335316Domain d5jmma_: 5jmm A: [334113]
      automated match to d3q95b_
      complexed with edo, gol, qso
    2. 2335317Domain d5jmmb_: 5jmm B: [334259]
      automated match to d3q95b_
      complexed with edo, gol, qso
  65. Domain(s) for 5tn9:
    1. 2335334Domain d5tn9a_: 5tn9 A: [329854]
      automated match to d3q95b_
      complexed with 7ec
    2. 2335335Domain d5tn9b_: 5tn9 B: [329853]
      automated match to d3q95b_
      complexed with 7ec
    3. 2335336Domain d5tn9c_: 5tn9 C: [329912]
      automated match to d3q95b_
      complexed with 7ec
    4. 2335337Domain d5tn9d_: 5tn9 D: [329844]
      automated match to d3q95b_
      complexed with 7ec
  66. Domain(s) for 5tnb:
    1. 2335310Domain d5tnba_: 5tnb A: [329887]
      automated match to d3q95b_
      complexed with 7eb
    2. 2335311Domain d5tnbb_: 5tnb B: [329938]
      automated match to d3q95b_
      complexed with 7eb
    3. 2335312Domain d5tnbc_: 5tnb C: [329882]
      automated match to d3q95b_
      complexed with 7eb
    4. 2335313Domain d5tnbd_: 5tnb D: [329842]
      automated match to d3q95b_
      complexed with 7eb
  67. Domain(s) for 5u2b:
    1. 2335328Domain d5u2ba_: 5u2b A: [333575]
      automated match to d3q95b_
      complexed with 6wv
    2. 2335329Domain d5u2bb_: 5u2b B: [333624]
      automated match to d3q95b_
      complexed with 6wv
    3. 2335330Domain d5u2bc_: 5u2b C: [333529]
      automated match to d3q95b_
      complexed with 6wv
    4. 2335331Domain d5u2bd_: 5u2b D: [333605]
      automated match to d3q95b_
      complexed with 6wv
    5. 2335332Domain d5u2be_: 5u2b E: [333563]
      automated match to d3q95b_
      complexed with 6wv
    6. 2335333Domain d5u2bf_: 5u2b F: [333539]
      automated match to d3q95b_
      complexed with 6wv
  68. Domain(s) for 5ufw:
    1. 3048078Domain d5ufwa_: 5ufw A: [348140]
      automated match to d3erta_
      complexed with 86v
    2. 3048111Domain d5ufwb_: 5ufw B: [348173]
      automated match to d3erta_
      complexed with 86v
  69. Domain(s) for 5ufx:
    1. 3048142Domain d5ufxa_: 5ufx A: [348204]
      automated match to d3erta_
      complexed with 86y
    2. 3048229Domain d5ufxb_: 5ufx B: [348291]
      automated match to d3erta_
      complexed with 86y
  70. Domain(s) for 5w9d:
    1. 2335255Domain d5w9da_: 5w9d A: [340173]
      automated match to d3erta_
      complexed with 9xy; mutant
    2. 2335256Domain d5w9db_: 5w9d B: [340165]
      automated match to d3erta_
      complexed with 9xy; mutant
  71. Domain(s) for 6c42:
    1. 3049898Domain d6c42b_: 6c42 B: [349960]
      automated match to d3erta_
      complexed with 85m
    2. 3049945Domain d6c42a_: 6c42 A: [350007]
      automated match to d3erta_
      complexed with 85m

More info for Species Human (Homo sapiens) [TaxId:9606] from a.123.1.1 Estrogen receptor alpha

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.123.1.1 Estrogen receptor alpha: