PDB entry 6iar

View 6iar on RCSB PDB site
Description: Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
Class: DNA binding protein
Keywords: Nuclear Hormone Receptor Inhibitor Downregulation Estrogen receptor modulators, DNA BINDING PROTEIN
Deposited on 2018-11-27, released 2019-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-24, with a file datestamp of 2019-04-19.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Estrogen receptor
  Species: Homo sapiens [TaxId:9606]
  Gene: ESR1, ESR, NR3A1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03372 (0-236)
    • conflict (71)
    • conflict (107)
    • conflict (225)
  Domains in SCOPe 2.08: d6iara_
• Heterogens: H8W, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iarA (A:)
  alsltadqmvsalldaeppilyseydptrpfsmmglltnladrelvhminwakrvpgfvd
  ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
  atssrfrmmnlqgeefvclksiillnsgvytfsstlksleekdhihrvldkitdtlihlm
  akagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemldah