Lineage for d2qxsa_ (2qxs A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2008476Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2008477Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2008478Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)
  6. 2008578Protein Estrogen receptor alpha [48519] (1 species)
  7. 2008579Species Human (Homo sapiens) [TaxId:9606] [48520] (64 PDB entries)
    Uniprot P03372 307-551
  8. 2008583Domain d2qxsa_: 2qxs A: [167872]
    automated match to d1qkua_
    protein/DNA complex; complexed with ral; mutant

Details for d2qxsa_

PDB Entry: 2qxs (more details), 1.7 Å

PDB Description: crystal structure of antagonizing mutant 536s of the estrogen receptor alpha ligand binding domain complexed to raloxifene
PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2qxsa_:

Sequence, based on SEQRES records: (download)

>d2qxsa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
ah

Sequence, based on observed residues (ATOM records): (download)

>d2qxsa_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydprpfsasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemldah

SCOPe Domain Coordinates for d2qxsa_:

Click to download the PDB-style file with coordinates for d2qxsa_.
(The format of our PDB-style files is described here.)

Timeline for d2qxsa_: