PDB entry 4q50

View 4q50 on RCSB PDB site
Description: The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen
Class: hormone binding protein
Keywords: Acquired SERM-Resistance, Breast Cancer, Activating Mutation, SERM-ER structure, Alpha Helix, Nuclear hormone receptor, hormone binding protein
Deposited on 2014-04-15, released 2015-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-02-24, with a file datestamp of 2016-02-19.
Experiment type: XRAY
Resolution: 3.07 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50a_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50b_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50c_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50d_
  • Chain 'E':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50e_
  • Chain 'F':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50f_
  • Chain 'G':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50g_
  • Chain 'H':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4q50h_
  • Heterogens: OHT, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q50A (A:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50A (A:)
alsltadqmvsalldaeppilysmmglltnladrelvhminwakrvpgfvdltlhdqvhl
lecawleilmiglvwrsmehpkllfapnllldrnqgkgmveifdmllatssrfrmmnlqg
eefvclksiillnsgvysleekdhihrvldkitdtlihlmakagltlqqqhqrlaqllli
lshirhmsnkgmehlysvvplyglllemld

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4q50B (B:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50B (B:)
alsltadqmvsalldaeppilysemmglltnladrelvhminwakrvpgfvdltlhdqvh
llecawleilmiglvwrsmehpgkllfapnllldrnqgkcgmveifdmllatssrfrmmn
lqgeefvclksiillnsgvleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlll
ilshirhmsnkgmehlysmlyglllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4q50C (C:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50C (C:)
lalsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdq
vhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvmveifdmllatssrfrm
mnlqgeefvclksiillnsgvytsstsleekdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysvvplyglllemlda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4q50D (D:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50D (D:)
lalsltadqmvsalldaeppilyseasmmglltnladrelvhminwakrvpgfvdltlhd
qvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllatssr
frmmnlqgeefvclksiillnsgvksleekdhihrvldkitdtlihlmakagltlqqqhq
rlaqlllilshirhmsnkgmehlysmlyglllemld

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4q50E (E:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50E (E:)
lalsltadqmvsalldaeppilyseyasmmglltnladrelvhminwakrvpgfvdltlh
dqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvgmveifdmllatssr
frmmnlqgeefvclksiillnsgvytfsleekdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmlyglllemld

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4q50F (F:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50F (F:)
alsltadqmvsalldaeppilyseypfseasmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvtfsleekdhihrvldkitdtlihlmakagltl
qqqhqrlaqlllilshirhmsnkgmehlyslyglllemld

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4q50G (G:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50G (G:)
alsltadqmvsalldaeppilyseyasmmglltnladrelvhminwakrvpgfvdltlhd
qvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllatssr
frmmnlqgeefvclksiillnsgvytsleekdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysmplyglllemlda

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4q50H (H:)
snamkrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrel
vhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnq
gkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdh
ihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvv
plyglllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >4q50H (H:)
alsltadqmvsalldaeppilyseyasmmglltnladrelvhminwakrvpgfvdltlhd
qvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllatssr
frmmnlqgeefvclksiillnsgvytfsleekdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlyplyglllemlda