Lineage for d4q50b_ (4q50 B:)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2728284Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2728285Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2728286Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)
  6. 2728396Protein Estrogen receptor alpha [48519] (1 species)
  7. 2728397Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
    Uniprot P03372 307-551
  8. 2728640Domain d4q50b_: 4q50 B: [271433]
    automated match to d3q95b_
    complexed with oht, so4; mutant

Details for d4q50b_

PDB Entry: 4q50 (more details), 3.07 Å

PDB Description: the estrogen receptor alpha ligand binding domain d538g mutant in complex with 4-hydroxytamoxifen
PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d4q50b_:

Sequence, based on SEQRES records: (download)

>d4q50b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplyglllemld

Sequence, based on observed residues (ATOM records): (download)

>d4q50b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilysemmglltnladrelvhminwakrvpgfvdltlhdqvh
llecawleilmiglvwrsmehpgkllfapnllldrnqgkcgmveifdmllatssrfrmmn
lqgeefvclksiillnsgvleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlll
ilshirhmsnkgmehlysmlyglllemld

SCOPe Domain Coordinates for d4q50b_:

Click to download the PDB-style file with coordinates for d4q50b_.
(The format of our PDB-style files is described here.)

Timeline for d4q50b_: