PDB entry 6v87

View 6v87 on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-Hydroxytamoxifen
Class: transcription
Keywords: Estrogen Receptor, SERM, Activating Mutation, Breast Cancer, TRANSCRIPTION
Deposited on 2019-12-10, released 2019-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (88)
      • conflict (124)
      • conflict (237)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d6v87a_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • conflict (88)
      • conflict (124)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d6v87b_
  • Heterogens: OHT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v87A (A:)
hhhhhhenlyfqsmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladr
elvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldr
nqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleek
dhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkskn
vvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6v87A (A:)
sltadqmvsalldaeppilysepfseasmmglltnladrelvhminwakrvpgfvdltlh
dqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatss
rfrmmnlqgeefvclksiillnsgdhihrvldkitdtlihlmakagltlqqqhqrlaqll
lilshirhmsnkgmehlysmksplsdlllemld

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v87B (B:)
hhhhhhenlyfqsmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladr
elvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldr
nqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleek
dhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkskn
vvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6v87B (B:)
alsltadqmvsalldaeppilyseydptmmglltnladrelvhminwakrvpgfvdltlh
dqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagltlqqqhqrl
aqlllilshirhmsnkgmehlyslsdlllemlda