PDB entry 7jhd

View 7jhd on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide
Class: transcription
Keywords: Breast Cancer, Synthetic Agonist, Drug Resistance, Apoptosis, TRANSCRIPTION
Deposited on 2020-07-20, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (233)
    Domains in SCOPe 2.08: d7jhda_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (233)
    Domains in SCOPe 2.08: d7jhdb_
  • Chain 'C':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, BHLHE75, SRC2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, BHLHE75, SRC2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: V9J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7jhdA (A:)
mslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllem
ldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7jhdA (A:)
alsltadqmvsalldaeppilysefseasmmglltnladrelvhminwakrvpgfvdltl
hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllats
srfrmmnlqgeefvclksiillnsgvytdhihrvldkitdtlihlmakagltlqqqhqrl
aqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jhdB (B:)
mslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllem
ldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7jhdB (B:)
alsltadqmvsalldaeppilyseydseasmmglltnladrelvhminwakrvpgfvdlt
lhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagltlqqqhq
rlaqlllilshirhmsnkgmehlysmkckplsdlllemldahr

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.