PDB entry 6dfn

View 6dfn on RCSB PDB site
Description: Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa
Class: nuclear protein
Keywords: ERA, antagonist, inverse agonist, receptor, breast cancer, degrader, ligand, estrogen receptor, NUCLEAR PROTEIN
Deposited on 2018-05-15, released 2019-02-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (98)
      • conflict (262)
    Domains in SCOPe 2.07: d6dfna_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (98)
      • conflict (262)
    Domains in SCOPe 2.07: d6dfnb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (98)
      • conflict (262)
    Domains in SCOPe 2.07: d6dfnc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • conflict (98)
      • conflict (262)
    Domains in SCOPe 2.07: d6dfnd_
  • Heterogens: G9J, NI, G91, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6dfnA (A:)
    mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
    trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
    rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
    lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
    irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt
    

    Sequence, based on observed residues (ATOM records): (download)
    >6dfnA (A:)
    lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
    gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
    dmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlih
    lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmvvpsydlllemlda
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6dfnB (B:)
    mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
    trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
    rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
    lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
    irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt
    

    Sequence, based on observed residues (ATOM records): (download)
    >6dfnB (B:)
    lalsltadqmvsalldaeppilysefseasmmglltnladrelvhminwakrvpgfvdlt
    shdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllat
    ssrfrmmnlqgeefvclksiillnsgleekdhihrvldkitdtlihlmakagltlqqqhq
    rlaqlllilshirhmsnkgmehlysmksydlllemlda
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6dfnC (C:)
    mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
    trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
    rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
    lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
    irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt
    

    Sequence, based on observed residues (ATOM records): (download)
    >6dfnC (C:)
    lsltadqmvsalldaeppilysepfseasmmglltnladrelvhminwakrvpgfvdlts
    hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllats
    srfrmmnlqgeefvclksiillnsgvyttlksleekdhihrvldkitdtlihlmakaglt
    lqqqhqrlaqlllilshirhmsnkgmehlysmknvvpsydlllemlda
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >6dfnD (D:)
    mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
    trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
    rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
    lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
    irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt
    

    Sequence, based on observed residues (ATOM records): (download)
    >6dfnD (D:)
    lalsltadqmvsalldaeppilyseysmmglltnladrelvhminwakrvpgfvdltshd
    qvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllatssr
    frmmnlqgeefvclksiillnsgvytksleekdhihrvldkitdtlihlmakagltlqqq
    hqrlaqlllilshirhmsnkgmehlysmvpsydlllemlda