PDB entry 6psj

View 6psj on RCSB PDB site
Description: Bazedoxifene in Complex with Y537S Estrogen Receptor Alpha Ligand Binding Domain
Class: transcription
Keywords: Estrogen Receptor, Y537S, Bazedoxifene, Steroid, Hormone, TRANSCRIPTION
Deposited on 2019-07-12, released 2019-11-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • engineered mutation (88)
      • engineered mutation (124)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d6psja_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (14-End)
      • engineered mutation (88)
      • engineered mutation (124)
      • engineered mutation (237)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d6psjb_
  • Heterogens: 29S, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6psjA (A:)
hhhhhhenlyfqsmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladr
elvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldr
nqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleek
dhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkskn
vvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6psjA (A:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmakaglt
lqqqhqrlaqlllilshirhmsnkgmehlysmknvvplsdlllemldahrlh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6psjB (B:)
hhhhhhenlyfqsmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladr
elvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldr
nqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleek
dhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkskn
vvplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6psjB (B:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvykdhihrvldkitdtlihlmakagltlqqqhqrlaqll
lilshirhmsnkgmehlyssknvvplsdlllemld