PDB entry 2qzo

View 2qzo on RCSB PDB site
Description: Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916
Class: transcription
Keywords: Protein-Ligand Complex, DNA-binding, Lipid-binding, Metal-binding, Nucleus, Phosphorylation, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc-finger
Deposited on 2007-08-16, released 2008-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (240)
    Domains in SCOPe 2.08: d2qzoa_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (240)
    Domains in SCOPe 2.08: d2qzob_
  • Chain 'C':
    Compound: nuclear receptor coactivator 2
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Species: Mus musculus, synthetic [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: KN1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qzoA (A:)
sikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
cvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >2qzoA (A:)
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrgmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvleekdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qzoB (B:)
sikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
cvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >2qzoB (B:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytfleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.