SCOPe 2.08: Domain d6sq0a1: 6sq0 A:307-552

Lineage for d6sq0a1 (6sq0 A:307-552)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d6sq0a1: 6sq0 A:307-552 [376270]
   Other proteins in same PDB: d6sq0a2
   automated match to d3erta_
   complexed with lrq

Details for d6sq0a1

PDB Entry: 6sq0, 1.77 Å

PDB Description: era_l536s (l536s/c381s/c471s,c530s) in complex with a bridged tetracyclic indole (compound 8)

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d6sq0a1:

Sequence, based on SEQRES records:

>d6sq0a1 a.123.1.1 (A:307-552) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda
hrlhap

Sequence, based on observed residues (ATOM records):

>d6sq0a1 a.123.1.1 (A:307-552) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseeasmmglltnladrelvhminwakrvpgfvdltlhd
qvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssr
frmmnlqgeefvclksiillnsgvytfleekdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysmpsydlllemldahrlhap

Timeline for d6sq0a1:

• d6sq0a1 first appeared in SCOPe 2.07