PDB entry 6sq0

View 6sq0 on RCSB PDB site
Description: ERa_L536S (L536S/C381S/C471S,C530S) in complex with a bridged tetracyclic indole (compound 8)
Class: gene regulation
Keywords: oestrogen receptor, oestrogen binding domain, GENE REGULATION
Deposited on 2019-09-03, released 2019-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (4-End)
      • expression tag (0-3)
      • engineered mutation (78)
      • engineered mutation (114)
      • engineered mutation (233)
    Domains in SCOPe 2.08: d6sq0a1, d6sq0a2
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (78)
      • engineered mutation (114)
      • engineered mutation (233)
    Domains in SCOPe 2.08: d6sq0b_
  • Heterogens: LRQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6sq0A (A:)
gshmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwak
rvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmv
eifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldki
tdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydllle
mldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6sq0A (A:)
gshmalsltadqmvsalldaeppilyseeasmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytfleekdhihrvldkitdtlihlmakagltl
qqqhqrlaqlllilshirhmsnkgmehlysmpsydlllemldahrlhap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6sq0B (B:)
gshmalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwak
rvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmv
eifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldki
tdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydllle
mldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6sq0B (B:)
ltadqmvsalldaeppilyseyeasmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgdhihrvldkitdtlihlmakagltlqqqhqrlaqlllil
shirhmsnkgmehlysmkpsydlllemlda