PDB entry 7kbs

View 7kbs on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with Raloxifene
Class: transcription
Keywords: Estrogen Receptor, Breast Cancer, Selective Estrogen Receptor Modulator, TRANSCRIPTION
Deposited on 2020-10-02, released 2020-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • engineered mutation (89)
      • engineered mutation (125)
      • engineered mutation (238)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d7kbsa_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • expression tag (14)
      • engineered mutation (89)
      • engineered mutation (125)
      • engineered mutation (238)
      • engineered mutation (244)
    Domains in SCOPe 2.08: d7kbsb1, d7kbsb2
  • Heterogens: RAL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kbsA (A:)
hhhhhhenlyfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7kbsA (A:)
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahr
lh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kbsB (B:)
hhhhhhenlyfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7kbsB (B:)
salsltadqmvsalldaeppilyseydptrpfasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytfksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda