PDB entry 6vmu

View 6vmu on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative with Selective Estrogen Receptor Degrader Properties
Class: transcription
Keywords: Estrogen Receptor, selective estrogen receptor degrader, SERD, breast cancer, nuclear hormone receptor, TRANSCRIPTION
Deposited on 2020-01-28, released 2020-02-05
Made obsolete by 7ujf on 2022-06-15

The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vmua_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • expression tag (14)
      • conflict (89)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vmub1, d6vmub2
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • conflict (89)
      • conflict (125)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vmuc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (15-End)
      • conflict (89)
      • conflict (238)
      • conflict (244)
    Domains in SCOPe 2.08: d6vmud_
  • Heterogens: R3V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6vmuA (A:)
hhhhhhenylfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vmuA (A:)
alsltadqmvsalldaeppilyseydptrpsmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemldahrlh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6vmuB (B:)
hhhhhhenylfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vmuB (B:)
salsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6vmuC (C:)
hhhhhhenylfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vmuC (C:)
alsltadqmvsalldaeppilyseydptrpfeasmmglltnladrelvhminwakrvpgf
vdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdm
llatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknpsydlllemldahrlh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6vmuD (D:)
hhhhhhenylfqsmsalsltadqmvsalldaeppilyseydptrpfseasmmglltnlad
relvhminwakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllld
rnqgksvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlkslee
kdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksk
nvvpsydlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6vmuD (D:)
alsltadqmvsalldaeppilyseydptrpfssmmglltnladrelvhminwakrvpgfv
dltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvpsydlllemlda