SCOPe 2.08: Domain d2q70a_: 2q70 A:

Lineage for d2q70a_ (2q70 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d2q70a_: 2q70 A: [150072]
   automated match to d1qkta_
   complexed with dc8

Details for d2q70a_

PDB Entry: 2q70, 1.95 Å

PDB Description: estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2q70a_:

Sequence, based on SEQRES records:

>d2q70a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllemld
ahrl

Sequence, based on observed residues (ATOM records):

>d2q70a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydpseasmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysmvplydlllemldahrl

Timeline for d2q70a_:

• d2q70a_ first appeared in SCOP 1.75, called d2q70a1
  
• d2q70a_ appears in SCOPe 2.07