SCOPe 2.08: Domain d5u2bc_: 5u2b C:

Lineage for d5u2bc_ (5u2b C:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d5u2bc_: 5u2b C: [333529]
   automated match to d3q95b_
   complexed with 6wv

Details for d5u2bc_

PDB Entry: 5u2b, 2.22 Å

PDB Description: crystal structure of the er-alpha ligand-binding domain (y537s) in complex with the phenylamino-substituted estrogen, (8r,9s,13s,14s, 17s)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro- 6h-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide

PDB Compounds: (C:) Estrogen receptor

SCOPe Domain Sequences for d5u2bc_:

Sequence, based on SEQRES records:

>d5u2bc_ a.123.1.1 (C:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
rskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdl
llemldahrl

Sequence, based on observed residues (ATOM records):

>d5u2bc_ a.123.1.1 (C:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
rskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldki
tdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcvplsdlllemld
ahrl

Timeline for d5u2bc_:

• d5u2bc_ first appeared in SCOPe 2.06
  
• d5u2bc_ appears in SCOPe 2.07