SCOPe 2.08: Domain d6df6b_: 6df6 B:

Lineage for d6df6b_ (6df6 B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d6df6b_: 6df6 B: [365087]
   automated match to d3q95b_
   complexed with g8y, gol

Details for d6df6b_

PDB Entry: 6df6, 2.5 Å

PDB Description: crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab

PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d6df6b_:

Sequence, based on SEQRES records:

>d6df6b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
a

Sequence, based on observed residues (ATOM records):

>d6df6b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseypfseasmmglltnladrelvhminwakrvpgfvd
ltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvekdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysmkpsydlllemlda

Timeline for d6df6b_:

• d6df6b_ first appeared in SCOPe 2.07