SCOPe 2.07: Domain d5tnba_: 5tnb A:

Lineage for d5tnba_ (5tnb A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (71 PDB entries)
   Uniprot P03372 307-551

8. Domain d5tnba_: 5tnb A: [329887]
   automated match to d3q95b_
   complexed with 7eb

Details for d5tnba_

PDB Entry: 5tnb, 2.08 Å

PDB Description: crystal structure of the er-alpha ligand-binding domain (l372s,l536s) in complex with the obhs-bsc, 4-bromophenyl (1r,2r,4s)-6-(4-(2- (dimethylamino)ethoxy)phenyl)-5-(4-hydroxyphenyl)-7- oxabicyclo[2.2.1]hept-5-ene-2-sulfonate

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d5tnba_:

Sequence, based on SEQRES records:

>d5tnba_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
a

Sequence, based on observed residues (ATOM records):

>d5tnba_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytfltlksleekdhihrvldkitdtlihlmakagl
tlqqqhqrlaqlllilshirhmsnkgmehlysmkvpsydlllemlda

Timeline for d5tnba_:

• d5tnba_ first appeared in SCOPe 2.06