SCOPe 2.08: Domain d2r6ya_: 2r6y A:

Lineage for d2r6ya_ (2r6y A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d2r6ya_: 2r6y A: [151623]
   automated match to d1qkta_
   protein/DNA complex; complexed with llc

Details for d2r6ya_

PDB Entry: 2r6y, 2 Å

PDB Description: estrogen receptor alpha ligand-binding domain in complex with a serm

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2r6ya_:

Sequence, based on SEQRES records:

>d2r6ya_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllemld
ahrl

Sequence, based on observed residues (ATOM records):

>d2r6ya_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydpsmmglltnladrelvhminwakrvpgfvdltl
hdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllats
srfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmvplydlllemldahrl

Timeline for d2r6ya_:

• d2r6ya_ first appeared in SCOP 1.75, called d2r6ya1
  
• d2r6ya_ appears in SCOPe 2.07