SCOPe 2.08: Domain d6cbza_: 6cbz A:

Lineage for d6cbza_ (6cbz A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d6cbza_: 6cbz A: [350411]
   automated match to d3q95b_
   complexed with est, gol; mutant

Details for d6cbza_

PDB Entry: 6cbz, 1.65 Å

PDB Description: estrogen receptor alpha ligand binding domain y537s mutant in complex with estradiol and grip peptide

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d6cbza_:

Sequence, based on SEQRES records:

>d6cbza_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
sltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr
l

Sequence, based on observed residues (ATOM records):

>d6cbza_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
sltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvytdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl

Timeline for d6cbza_:

• d6cbza_ first appeared in SCOPe 2.07