SCOPe 2.08: Domain d3dt3a_: 3dt3 A:

Lineage for d3dt3a_ (3dt3 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d3dt3a_: 3dt3 A: [157848]
   automated match to d1qkua_
   complexed with 369

Details for d3dt3a_

PDB Entry: 3dt3, 2.4 Å

PDB Description: human estrogen receptor alpha lbd with gw368

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d3dt3a_:

Sequence, based on SEQRES records:

>d3dt3a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemld
ahrlha

Sequence, based on observed residues (ATOM records):

>d3dt3a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseseasmmglltnladrelvhminwakrvpgfvdltl
hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllats
srfrmmnlqgeefvclksiillnsgvytfsstlksleekdhihrvldkitdtlihlmaka
gltlqqqhqrlaqlllilshirhmsnkgmehlysmknvvplydlllemldahrlha

Timeline for d3dt3a_:

• d3dt3a_ first appeared in SCOP 1.75, called d3dt3a1
  
• d3dt3a_ appears in SCOPe 2.07