PDB entry 6wok

View 6wok on RCSB PDB site
Description: Crystal structure of estrogen receptor alpha in complex with receptor degrader 6
Class: nuclear protein
Keywords: ERA, antagonist, inverse agonist, receptor, breast cancer, degrader, ligand, estrogen receptor, NUCLEAR PROTEIN
Deposited on 2020-04-24, released 2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-01, with a file datestamp of 2020-06-26.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (98)
      • engineered mutation (262)
    Domains in SCOPe 2.08: d6woka_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (98)
      • engineered mutation (262)
    Domains in SCOPe 2.08: d6wokb_
  • Chain 'C':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (98)
      • engineered mutation (262)
    Domains in SCOPe 2.08: d6wokc_
  • Chain 'D':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (98)
      • engineered mutation (262)
    Domains in SCOPe 2.08: d6wokd_
  • Heterogens: U6D, G9J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6wokA (A:)
mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt

    Sequence, based on observed residues (ATOM records): (download) 
    >6wokA (A:)
lalsltadqmvsalldaeppilyseydsmmglltnladrelvhminwakrvpgfvdltsh
dqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytsleekdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6wokB (B:)
mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt

    Sequence, based on observed residues (ATOM records): (download) 
    >6wokB (B:)
lalsltadqmvsalldaeppilyseydptrsmmglltnladrelvhminwakrvpgfvdl
tshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmkvvpsydlllemld

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6wokC (C:)
mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt

    Sequence, based on observed residues (ATOM records): (download) 
    >6wokC (C:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkvpsydlllemld

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6wokD (D:)
mhhhhhhssgvdlgtenlyfqsnaikrskknslalsltadqmvsalldaeppilyseydp
trpfseasmmglltnladrelvhminwakrvpgfvdltshdqvhllecawleilmiglvw
rsmehpgkllfapnllldrnqgkcvegmveifdmllatssrfrmmnlqgeefvclksiil
lnsgvytflsstlksleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllilsh
irhmsnkgmehlysmkcknvvpsydlllemldahrlhapt

    Sequence, based on observed residues (ATOM records): (download) 
    >6wokD (D:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmpsydlllemld