SCOPe 2.07: Domain d5u2bb_: 5u2b B:

Lineage for d5u2bb_ (5u2b B:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (71 PDB entries)
   Uniprot P03372 307-551

8. Domain d5u2bb_: 5u2b B: [333624]
   automated match to d3q95b_
   complexed with 6wv

Details for d5u2bb_

PDB Entry: 5u2b, 2.22 Å

PDB Description: crystal structure of the er-alpha ligand-binding domain (y537s) in complex with the phenylamino-substituted estrogen, (8r,9s,13s,14s, 17s)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro- 6h-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide

PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d5u2bb_:

Sequence, based on SEQRES records:

>d5u2bb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllem
ldahr

Sequence, based on observed residues (ATOM records):

>d5u2bb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
nslalsltadqmvsalldaeppilyseydptasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
latssrfrmmnlqgeefvclksiillnsgvykdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Timeline for d5u2bb_:

• d5u2bb_ first appeared in SCOPe 2.06