Lineage for Protein: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2387558Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2387559Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2389935Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 protein domains)
  6. 2389994Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (6 species)
    contains an extra alpha-helical domain

Species:

  1. 2389995Human coronavirus 229E [TaxId:11137] [89348] (2 PDB entries)
    1. Domains for 1p9s:
      1. 2389998Domain d1p9sa_: 1p9s A: [87999]
        complexed with dio
      2. 2389999Domain d1p9sb_: 1p9s B: [88000]
        complexed with dio
    2. Domains for 2zu2:
      1. 2389996Domain d2zu2a_: 2zu2 A: [171525]
        automated match to d1p9sa_
        complexed with dtz, mpd
      2. 2389997Domain d2zu2b_: 2zu2 B: [171526]
        automated match to d1p9sa_
        complexed with dtz, mpd
  2. 2390000Human coronavirus [TaxId:443239] [188597] (4 PDB entries)
    1. Domain for 2bw6:
    2. Domains for 3d23:
      1. 2390004Domain d3d23a1: 3d23 A:1-300 [173627]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      2. 2390005Domain d3d23b1: 3d23 B:1-300 [173628]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      3. 2390006Domain d3d23c_: 3d23 C: [173629]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      4. 2390007Domain d3d23d_: 3d23 D: [173630]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
    3. Domains for 3tlo:
      1. 2390001Domain d3tloa_: 3tlo A: [200833]
        automated match to d3tlob_
        complexed with gol, peg
      2. 2390002Domain d3tlob_: 3tlo B: [194725]
        automated match to d2zu2b_
        complexed with gol, peg
    4. Domains for 5nh0:
      1. 3052088Domain d5nh0c_: 5nh0 C: [352150]
        automated match to d3tloa_
        complexed with 8x8, dms, gol
      2. 3052092Domain d5nh0a_: 5nh0 A: [352154]
        automated match to d3tloa_
        complexed with 8x8, dms, gol
      3. 3052153Domain d5nh0b_: 5nh0 B: [352215]
        automated match to d3tloa_
        complexed with 8x8, dms, gol
  3. 2390008Porcine transmissible gastroenteritis coronavirus [TaxId:11151] [193539] (1 PDB entry)
  4. 2390013Sars coronavirus sin2774 [TaxId:235410] [187498] (2 PDB entries)
    1. Domain for 2bx3:
    2. Domain for 2bx4:
  5. 2390016SARS coronavirus [TaxId:227859] [89349] (73 PDB entries)
    1. Domains for 1q2w:
      1. 2390070Domain d1q2wa_: 1q2w A: [88355]
        Other proteins in same PDB: d1q2wb2
        complexed with mpd
      2. 2390071Domain d1q2wb1: 1q2w B:1-301 [88356]
        Other proteins in same PDB: d1q2wb2
        complexed with mpd
    2. Domains for 1uj1:
      1. 2390042Domain d1uj1a_: 1uj1 A: [99450]
      2. 2390043Domain d1uj1b_: 1uj1 B: [99451]
    3. Domains for 1uk2:
      1. 2390072Domain d1uk2a_: 1uk2 A: [99481]
      2. 2390073Domain d1uk2b_: 1uk2 B: [99482]
    4. Domains for 1uk3:
      1. 2390086Domain d1uk3a_: 1uk3 A: [99483]
      2. 2390087Domain d1uk3b_: 1uk3 B: [99484]
    5. Domains for 1uk4:
      1. 2390088Domain d1uk4a_: 1uk4 A: [99485]
        complexed with ato
      2. 2390089Domain d1uk4b_: 1uk4 B: [99486]
        complexed with ato
    6. Domain for 1z1i:
    7. Domains for 1z1j:
      1. 2390107Domain d1z1ja_: 1z1j A: [162357]
        automated match to d1uj1b_
        mutant
      2. 2390108Domain d1z1jb_: 1z1j B: [162358]
        automated match to d1uj1b_
        mutant
    8. Domain for 2a5a:
    9. Domain for 2a5i:
    10. Domains for 2a5k:
      1. 2390062Domain d2a5ka_: 2a5k A: [162694]
        automated match to d1uj1b_
        complexed with azp
      2. 2390063Domain d2a5kb_: 2a5k B: [162695]
        automated match to d1uj1b_
        complexed with azp
    11. Domain for 2alv:
    12. Domain for 2c3s:
    13. Domains for 2duc:
      1. 2390057Domain d2duca_: 2duc A: [146586]
        automated match to d1uj1b_
      2. 2390058Domain d2ducb_: 2duc B: [146587]
        automated match to d1uj1b_
    14. Domains for 2gt7:
      1. 2390023Domain d2gt7a_: 2gt7 A: [164833]
        automated match to d1uj1b_
        complexed with mes
      2. 2390024Domain d2gt7b_: 2gt7 B: [164834]
        automated match to d1uj1b_
        complexed with mes
    15. Domain for 2gt8:
    16. Domain for 2gtb:
    17. Domain for 2gx4:
    18. Domain for 2gz7:
    19. Domain for 2gz8:
    20. Domain for 2gz9:
    21. Domain for 2h2z:
    22. Domain for 2hob:
    23. Domains for 2op9:
      1. 2390021Domain d2op9a2: 2op9 A:1-301 [148961]
        Other proteins in same PDB: d2op9a3
        automated match to d1q2wb_
        complexed with wr1
      2. 2390022Domain d2op9b_: 2op9 B: [148962]
        Other proteins in same PDB: d2op9a3
        automated match to d1q2wb_
        complexed with wr1
    24. Domain for 2pwx:
    25. Domains for 2q6g:
      1. 2390079Domain d2q6ga_: 2q6g A: [167455]
        automated match to d1uj1b_
        mutant
      2. 2390080Domain d2q6gb_: 2q6g B: [167456]
        automated match to d1uj1b_
        mutant
    26. Domains for 2qc2:
      1. 2390112Domain d2qc2a1: 2qc2 A:1-304 [167515]
        Other proteins in same PDB: d2qc2a2
        automated match to d1uj1b_
        mutant
      2. 2390113Domain d2qc2b_: 2qc2 B: [167516]
        Other proteins in same PDB: d2qc2a2
        automated match to d1uj1b_
        mutant
    27. Domain for 2qcy:
    28. Domain for 2qiq:
    29. Domain for 2v6n:
    30. Domain for 2z3c:
    31. Domain for 2z3d:
    32. Domain for 2z3e:
    33. Domain for 2z94:
    34. Domain for 2z9g:
    35. Domains for 2z9j:
      1. 2390039Domain d2z9ja_: 2z9j A: [154254]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, dtz
      2. 2390040Domain d2z9jb_: 2z9j B: [154255]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, dtz
    36. Domains for 2z9k:
      1. 2390029Domain d2z9ka_: 2z9k A: [154256]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, doz
      2. 2390030Domain d2z9kb_: 2z9k B: [154257]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, doz
    37. Domains for 2z9l:
      1. 2390055Domain d2z9la_: 2z9l A: [154258]
        automated match to d1uj1b_
        complexed with daz, dms
      2. 2390056Domain d2z9lb_: 2z9l B: [154259]
        automated match to d1uj1b_
        complexed with daz, dms
    38. Domain for 2zu4:
    39. Domain for 2zu5:
    40. Domains for 3atw:
      1. 2390100Domain d3atwa_: 3atw A: [172333]
        automated match to d1uj1b_
      2. 2390101Domain d3atwb_: 3atw B: [172334]
        automated match to d1uj1b_
    41. Domain for 3avz:
    42. Domain for 3aw0:
    43. Domains for 3aw1:
      1. 2390074Domain d3aw1a_: 3aw1 A: [172360]
        automated match to d1uj1b_
        mutant
      2. 2390075Domain d3aw1b_: 3aw1 B: [172361]
        automated match to d1uj1b_
        mutant
    44. Domain for 3d62:
    45. Domain for 3f9e:
    46. Domains for 3f9f:
      1. 2390068Domain d3f9fa_: 3f9f A: [175591]
        automated match to d1uj1b_
        mutant
      2. 2390069Domain d3f9fb_: 3f9f B: [175592]
        automated match to d1uj1b_
        mutant
    47. Domains for 3f9g:
      1. 2390093Domain d3f9ga_: 3f9g A: [175593]
        automated match to d1q2wb_
        mutant
      2. 2390094Domain d3f9gb_: 3f9g B: [175594]
        automated match to d1q2wb_
        mutant
    48. Domains for 3f9h:
      1. 2390104Domain d3f9ha_: 3f9h A: [175595]
        automated match to d1uj1b_
        mutant
      2. 2390105Domain d3f9hb_: 3f9h B: [175596]
        automated match to d1uj1b_
        mutant
    49. Domain for 3fzd:
    50. Domains for 3m3s:
      1. 2390066Domain d3m3sa_: 3m3s A: [180804]
        automated match to d1uj1b_
        mutant
      2. 2390067Domain d3m3sb_: 3m3s B: [180805]
        automated match to d1uj1b_
        mutant
    51. Domain for 3sn8:
    52. Domain for 3sna:
    53. Domain for 3snb:
    54. Domain for 3snc:
    55. Domains for 3snd:
      1. 2390031Domain d3snda_: 3snd A: [185446]
        automated match to d1uj1b_
        complexed with mrd
      2. 2390032Domain d3sndb_: 3snd B: [185447]
        automated match to d1uj1b_
        complexed with mrd
    56. Domain for 3sne:
    57. Domain for 3szn:
    58. Domain for 3tit:
    59. Domain for 3tiu:
    60. Domain for 3tns:
    61. Domain for 3tnt:
    62. Domain for 3v3m:
    63. Domains for 3vb3:
      1. 2390049Domain d3vb3a_: 3vb3 A: [217737]
        automated match to d1uj1b_
        complexed with edo, peg
      2. 2390050Domain d3vb3b_: 3vb3 B: [217738]
        automated match to d2duca_
        complexed with edo, peg
    64. Domains for 4hi3:
      1. 2390047Domain d4hi3a_: 4hi3 A: [196960]
        automated match to d1z1ja_
        mutant
      2. 2390048Domain d4hi3b_: 4hi3 B: [197388]
        automated match to d1z1ja_
        mutant
    65. Domain for 4mds:
    66. Domains for 4tww:
      1. 2390097Domain d4twwa_: 4tww A: [309672]
        automated match to d1z1ja_
        complexed with 3a7
      2. 2390098Domain d4twwb_: 4tww B: [309673]
        automated match to d1z1ja_
        complexed with 3a7
    67. Domain for 4twx:
    68. Domain for 4twy:
    69. Domain for 4wy3:
    70. Domain for 5c5n:
    71. Domains for 5c5o:
      1. 2390027Domain d5c5oa_: 5c5o A: [318687]
        automated match to d1z1ja_
        complexed with sdj
      2. 2390028Domain d5c5ob_: 5c5o B: [318792]
        automated match to d1z1ja_
        complexed with sdj
    72. Domain for 5n19:
    73. Domain for 5n5o:
  6. 2390114Transmissible gastroenteritis virus [TaxId:11149] [74980] (3 PDB entries)
    1. Domains for 1lvo:
      1. 2390115Domain d1lvoa_: 1lvo A: [74284]
        complexed with dio, mrd, so4
      2. 2390116Domain d1lvob_: 1lvo B: [74285]
        complexed with dio, mrd, so4
      3. 2390117Domain d1lvoc_: 1lvo C: [74286]
        complexed with dio, mrd, so4
      4. 2390118Domain d1lvod_: 1lvo D: [74287]
        complexed with dio, mrd, so4
      5. 2390119Domain d1lvoe_: 1lvo E: [74288]
        complexed with dio, mrd, so4
      6. 2390120Domain d1lvof_: 1lvo F: [74289]
        complexed with dio, mrd, so4
    2. Domains for 1p9u:
      1. 2390121Domain d1p9ua_: 1p9u A: [88001]
        complexed with mrd, so4
      2. 2390122Domain d1p9ub_: 1p9u B: [88002]
        complexed with mrd, so4
      3. 2390123Domain d1p9uc_: 1p9u C: [88003]
        complexed with mrd, so4
      4. 2390124Domain d1p9ud_: 1p9u D: [88004]
        complexed with mrd, so4
      5. 2390125Domain d1p9ue_: 1p9u E: [88005]
        complexed with mrd, so4
      6. 2390126Domain d1p9uf_: 1p9u F: [88006]
        complexed with mrd, so4
    3. Domains for 2amp:
      1. 2390127Domain d2ampa_: 2amp A: [127021]
        automated match to d1lvod_
        complexed with i12
      2. 2390128Domain d2ampb_: 2amp B: [127022]
        automated match to d1lvod_
        complexed with i12

More info for Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) from b.47.1.4: Viral cysteine protease of trypsin fold

Timeline for Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) from b.47.1.4: Viral cysteine protease of trypsin fold: