Lineage for Protein: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057856Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 protein domains)
  6. 2057913Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (6 species)
    contains an extra alpha-helical domain

Species:

  1. 2057914Human coronavirus 229E [TaxId:11137] [89348] (2 PDB entries)
    1. Domains for 1p9s:
      1. 2057917Domain d1p9sa_: 1p9s A: [87999]
        complexed with dio
      2. 2057918Domain d1p9sb_: 1p9s B: [88000]
        complexed with dio
    2. Domains for 2zu2:
      1. 2057915Domain d2zu2a_: 2zu2 A: [171525]
        automated match to d1p9sa_
        complexed with dtz, mpd
      2. 2057916Domain d2zu2b_: 2zu2 B: [171526]
        automated match to d1p9sa_
        complexed with dtz, mpd
  2. 2057919Human coronavirus [TaxId:443239] [188597] (3 PDB entries)
    1. Domain for 2bw6:
    2. Domains for 3d23:
      1. 2057923Domain d3d23a1: 3d23 A:1-300 [173627]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      2. 2057924Domain d3d23b1: 3d23 B:1-300 [173628]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      3. 2057925Domain d3d23c_: 3d23 C: [173629]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
      4. 2057926Domain d3d23d_: 3d23 D: [173630]
        Other proteins in same PDB: d3d23a2, d3d23b2
        automated match to d1uj1b_
        protein/RNA complex
    3. Domains for 3tlo:
      1. 2057920Domain d3tloa_: 3tlo A: [200833]
        automated match to d3tlob_
        complexed with gol, peg
      2. 2057921Domain d3tlob_: 3tlo B: [194725]
        automated match to d2zu2b_
        complexed with gol, peg
  3. 2057927Porcine transmissible gastroenteritis coronavirus [TaxId:11151] [193539] (1 PDB entry)
  4. 2057932Sars coronavirus sin2774 [TaxId:235410] [187498] (2 PDB entries)
    1. Domain for 2bx3:
    2. Domain for 2bx4:
  5. 2057935SARS coronavirus [TaxId:227859] [89349] (71 PDB entries)
    1. Domains for 1q2w:
      1. 2057956Domain d1q2wa_: 1q2w A: [88355]
        Other proteins in same PDB: d1q2wb2
        complexed with mpd
      2. 2057957Domain d1q2wb1: 1q2w B:1-301 [88356]
        Other proteins in same PDB: d1q2wb2
        complexed with mpd
    2. Domains for 1uj1:
      1. 2057969Domain d1uj1a_: 1uj1 A: [99450]
      2. 2057970Domain d1uj1b_: 1uj1 B: [99451]
    3. Domains for 1uk2:
      1. 2057994Domain d1uk2a_: 1uk2 A: [99481]
      2. 2057995Domain d1uk2b_: 1uk2 B: [99482]
    4. Domains for 1uk3:
      1. 2058006Domain d1uk3a_: 1uk3 A: [99483]
      2. 2058007Domain d1uk3b_: 1uk3 B: [99484]
    5. Domains for 1uk4:
      1. 2058008Domain d1uk4a_: 1uk4 A: [99485]
        complexed with ato
      2. 2058009Domain d1uk4b_: 1uk4 B: [99486]
        complexed with ato
    6. Domain for 1z1i:
    7. Domains for 1z1j:
      1. 2058025Domain d1z1ja_: 1z1j A: [162357]
        automated match to d1uj1b_
        mutant
      2. 2058026Domain d1z1jb_: 1z1j B: [162358]
        automated match to d1uj1b_
        mutant
    8. Domain for 2a5a:
    9. Domain for 2a5i:
    10. Domains for 2a5k:
      1. 2057986Domain d2a5ka_: 2a5k A: [162694]
        automated match to d1uj1b_
        complexed with azp
      2. 2057987Domain d2a5kb_: 2a5k B: [162695]
        automated match to d1uj1b_
        complexed with azp
    11. Domain for 2alv:
    12. Domain for 2c3s:
    13. Domains for 2duc:
      1. 2057941Domain d2duca_: 2duc A: [146586]
        automated match to d1uj1b_
      2. 2057942Domain d2ducb_: 2duc B: [146587]
        automated match to d1uj1b_
    14. Domains for 2gt7:
      1. 2057948Domain d2gt7a_: 2gt7 A: [164833]
        automated match to d1uj1b_
        complexed with mes
      2. 2057949Domain d2gt7b_: 2gt7 B: [164834]
        automated match to d1uj1b_
        complexed with mes
    15. Domain for 2gt8:
    16. Domain for 2gtb:
    17. Domain for 2gx4:
    18. Domain for 2gz7:
    19. Domain for 2gz8:
    20. Domain for 2gz9:
    21. Domain for 2h2z:
    22. Domain for 2hob:
    23. Domains for 2op9:
      1. 2057945Domain d2op9a2: 2op9 A:1-301 [148961]
        Other proteins in same PDB: d2op9a3
        automated match to d1q2wb_
        complexed with wr1
      2. 2057946Domain d2op9b_: 2op9 B: [148962]
        Other proteins in same PDB: d2op9a3
        automated match to d1q2wb_
        complexed with wr1
    24. Domain for 2pwx:
    25. Domains for 2q6g:
      1. 2058001Domain d2q6ga_: 2q6g A: [167455]
        automated match to d1uj1b_
        mutant
      2. 2058002Domain d2q6gb_: 2q6g B: [167456]
        automated match to d1uj1b_
        mutant
    26. Domains for 2qc2:
      1. 2058011Domain d2qc2a1: 2qc2 A:1-304 [167515]
        Other proteins in same PDB: d2qc2a2
        automated match to d1uj1b_
        mutant
      2. 2058012Domain d2qc2b_: 2qc2 B: [167516]
        Other proteins in same PDB: d2qc2a2
        automated match to d1uj1b_
        mutant
    27. Domain for 2qcy:
    28. Domain for 2qiq:
    29. Domain for 2v6n:
    30. Domain for 2z3c:
    31. Domain for 2z3d:
    32. Domain for 2z3e:
    33. Domain for 2z94:
    34. Domain for 2z9g:
    35. Domains for 2z9j:
      1. 2057965Domain d2z9ja_: 2z9j A: [154254]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, dtz
      2. 2057966Domain d2z9jb_: 2z9j B: [154255]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, dtz
    36. Domains for 2z9k:
      1. 2057952Domain d2z9ka_: 2z9k A: [154256]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, doz
      2. 2057953Domain d2z9kb_: 2z9k B: [154257]
        automated match to d1uj1b_
        protein/RNA complex; complexed with dms, doz
    37. Domains for 2z9l:
      1. 2057981Domain d2z9la_: 2z9l A: [154258]
        automated match to d1uj1b_
        complexed with daz, dms
      2. 2057982Domain d2z9lb_: 2z9l B: [154259]
        automated match to d1uj1b_
        complexed with daz, dms
    38. Domain for 2zu4:
    39. Domain for 2zu5:
    40. Domains for 3atw:
      1. 2058020Domain d3atwa_: 3atw A: [172333]
        automated match to d1uj1b_
      2. 2058021Domain d3atwb_: 3atw B: [172334]
        automated match to d1uj1b_
    41. Domain for 3avz:
    42. Domain for 3aw0:
    43. Domains for 3aw1:
      1. 2057996Domain d3aw1a_: 3aw1 A: [172360]
        automated match to d1uj1b_
        mutant
      2. 2057997Domain d3aw1b_: 3aw1 B: [172361]
        automated match to d1uj1b_
        mutant
    44. Domain for 3d62:
    45. Domain for 3f9e:
    46. Domains for 3f9f:
      1. 2057992Domain d3f9fa_: 3f9f A: [175591]
        automated match to d1uj1b_
        mutant
      2. 2057993Domain d3f9fb_: 3f9f B: [175592]
        automated match to d1uj1b_
        mutant
    47. Domains for 3f9g:
      1. 2058013Domain d3f9ga_: 3f9g A: [175593]
        automated match to d1q2wb_
        mutant
      2. 2058014Domain d3f9gb_: 3f9g B: [175594]
        automated match to d1q2wb_
        mutant
    48. Domains for 3f9h:
      1. 2058022Domain d3f9ha_: 3f9h A: [175595]
        automated match to d1uj1b_
        mutant
      2. 2058023Domain d3f9hb_: 3f9h B: [175596]
        automated match to d1uj1b_
        mutant
    49. Domain for 3fzd:
    50. Domains for 3m3s:
      1. 2057990Domain d3m3sa_: 3m3s A: [180804]
        automated match to d1uj1b_
        mutant
      2. 2057991Domain d3m3sb_: 3m3s B: [180805]
        automated match to d1uj1b_
        mutant
    51. Domain for 3sn8:
    52. Domain for 3sna:
    53. Domain for 3snb:
    54. Domain for 3snc:
    55. Domains for 3snd:
      1. 2057954Domain d3snda_: 3snd A: [185446]
        automated match to d1uj1b_
        complexed with mrd
      2. 2057955Domain d3sndb_: 3snd B: [185447]
        automated match to d1uj1b_
        complexed with mrd
    56. Domain for 3sne:
    57. Domain for 3szn:
    58. Domain for 3tit:
    59. Domain for 3tiu:
    60. Domain for 3tns:
    61. Domain for 3tnt:
    62. Domain for 3v3m:
    63. Domains for 3vb3:
      1. 2057977Domain d3vb3a_: 3vb3 A: [217737]
        automated match to d1uj1b_
        complexed with edo, peg
      2. 2057978Domain d3vb3b_: 3vb3 B: [217738]
        automated match to d2duca_
        complexed with edo, peg
    64. Domains for 4hi3:
      1. 2057974Domain d4hi3a_: 4hi3 A: [196960]
        automated match to d1z1ja_
        mutant
      2. 2057975Domain d4hi3b_: 4hi3 B: [197388]
        automated match to d1z1ja_
        mutant
    65. Domain for 4mds:
    66. Domains for 4tww:
      1. 2058017Domain d4twwa_: 4tww A: [309672]
        automated match to d1z1ja_
        complexed with 3a7
      2. 2058018Domain d4twwb_: 4tww B: [309673]
        automated match to d1z1ja_
        complexed with 3a7
    67. Domain for 4twx:
    68. Domain for 4twy:
    69. Domain for 4wy3:
    70. Domain for 5c5n:
    71. Domains for 5c5o:
      1. 2275386Domain d5c5oa_: 5c5o A: [318687]
        automated match to d1z1ja_
        complexed with sdj
      2. 2275491Domain d5c5ob_: 5c5o B: [318792]
        automated match to d1z1ja_
        complexed with sdj
  6. 2058030Transmissible gastroenteritis virus [TaxId:11149] [74980] (3 PDB entries)
    1. Domains for 1lvo:
      1. 2058031Domain d1lvoa_: 1lvo A: [74284]
        complexed with dio, mrd, so4
      2. 2058032Domain d1lvob_: 1lvo B: [74285]
        complexed with dio, mrd, so4
      3. 2058033Domain d1lvoc_: 1lvo C: [74286]
        complexed with dio, mrd, so4
      4. 2058034Domain d1lvod_: 1lvo D: [74287]
        complexed with dio, mrd, so4
      5. 2058035Domain d1lvoe_: 1lvo E: [74288]
        complexed with dio, mrd, so4
      6. 2058036Domain d1lvof_: 1lvo F: [74289]
        complexed with dio, mrd, so4
    2. Domains for 1p9u:
      1. 2058037Domain d1p9ua_: 1p9u A: [88001]
        complexed with mrd, so4
      2. 2058038Domain d1p9ub_: 1p9u B: [88002]
        complexed with mrd, so4
      3. 2058039Domain d1p9uc_: 1p9u C: [88003]
        complexed with mrd, so4
      4. 2058040Domain d1p9ud_: 1p9u D: [88004]
        complexed with mrd, so4
      5. 2058041Domain d1p9ue_: 1p9u E: [88005]
        complexed with mrd, so4
      6. 2058042Domain d1p9uf_: 1p9u F: [88006]
        complexed with mrd, so4
    3. Domains for 2amp:
      1. 2058043Domain d2ampa_: 2amp A: [127021]
        automated match to d1lvod_
        complexed with i12
      2. 2058044Domain d2ampb_: 2amp B: [127022]
        automated match to d1lvod_
        complexed with i12

More info for Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) from b.47.1.4: Viral cysteine protease of trypsin fold

Timeline for Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) from b.47.1.4: Viral cysteine protease of trypsin fold: