PDB entry 6w2a

View 6w2a on RCSB PDB site
Description: 1.65 A resolution structure of SARS-CoV 3CL protease in complex with inhibitor 7j
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: PROTEASE, severe acute respiratory syndrome coronavirus, SARS 3CL protease Inhhibitors, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2020-03-05, released 2020-08-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-02, with a file datestamp of 2020-08-28.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Replicase polyprotein 1a
    Species: Human SARS coronavirus [TaxId:694009]
    Gene: 1a
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6U8 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.08: d6w2aa1, d6w2aa2
  • Chain 'B':
    Compound: Replicase polyprotein 1a
    Species: Human SARS coronavirus [TaxId:694009]
    Gene: 1a
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6U8 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.08: d6w2ab1, d6w2ab2
  • Heterogens: VDJ, QYS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w2aA (A:)
mhhhhhhsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpn
yedllirksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfs
vlacyngspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvha
gtdlegkfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlv
amkynyepltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftp
fdvvrqcsgv

    Sequence, based on observed residues (ATOM records): (download) 
    >6w2aA (A:)
hsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedlli
rksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyn
gspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdleg
kfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkyny
epltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrq
cs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w2aB (B:)
mhhhhhhsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpn
yedllirksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfs
vlacyngspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvha
gtdlegkfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlv
amkynyepltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftp
fdvvrqcsgv

    Sequence, based on observed residues (ATOM records): (download) 
    >6w2aB (B:)
hsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedlli
rksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyn
gspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdleg
kfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkyny
epltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrq
csg