SCOPe 2.08: Domain d7jr4a_: 7jr4 A:

Lineage for d7jr4a_ (7jr4 A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 proteins)

6. Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (8 species)
   contains an extra alpha-helical domain

7. Species Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049] [385979] (354 PDB entries)

8. Domain d7jr4a_: 7jr4 A: [390321]
   automated match to d3ea8a_
   complexed with dms, mlz
   has additional subdomain(s) that are not in the common domain

Details for d7jr4a_

PDB Entry: 7jr4, 1.55 Å

PDB Description: sars-cov-2 3cl protease with alternative conformation of the active site promoted by methylene-bridged cysteine and lysine residues

PDB Compounds: (A:) 3C-like proteinase

SCOPe Domain Sequences for d7jr4a_:

Sequence, based on SEQRES records:

>d7jr4a_ b.47.1.4 (A:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {Severe acute respiratory syndrome coronavirus 2 [TaxId: 2697049]}
sgfrkmafpsgkvegcmvqvtcgtttlnglwlddvvycprhvictsedmlnpnyedllir
ksnhnflvqagnvqlrvighsmqncvlklkvdtanpktpkykfvriqpgqtfsvlacyng
spsgvyqcamrpnftikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegn
fygpfvdrqtaqaagtdttitvnvlawlyaavingdrwflnrftttlndfnlvamkynye
pltqdhvdilgplsaqtgiavldmcaslkellqngmngrtilgsalledeftpfdvvrqc
sg

Sequence, based on observed residues (ATOM records):

>d7jr4a_ b.47.1.4 (A:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {Severe acute respiratory syndrome coronavirus 2 [TaxId: 2697049]}
sgfrkmafpsgkvegcmvqvtcgtttlnglwlddvvycprhvictmlnpnyedllirksn
hnflvqagnvqlrvighsmqncvlklkvdtanpktpkykfvriqpgqtfsvlacyngsps
gvyqcamrpnftikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegnfyg
pfvdrqtaqaagtdttitvnvlawlyaavingdrwflnrftttlndfnlvamkynyeplt
qdhvdilgplsaqtgiavldmcaslkellqngmngrtilgsalledeftpfdvvrqcsg

Timeline for d7jr4a_:

• d7jr4a_ first appeared in SCOPe 2.07