Lineage for d4mdsa1 (4mds A:1-302)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057856Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 protein domains)
  6. 2057913Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (6 species)
    contains an extra alpha-helical domain
  7. 2057935Species SARS coronavirus [TaxId:227859] [89349] (71 PDB entries)
  8. 2057944Domain d4mdsa1: 4mds A:1-302 [228110]
    Other proteins in same PDB: d4mdsa2
    automated match to d3tnta_
    complexed with 23h, dms

Details for d4mdsa1

PDB Entry: 4mds (more details), 1.6 Å

PDB Description: Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and non-covalent nanomolar inhibitors with an induced-fit binding
PDB Compounds: (A:) 3C-like proteinase

SCOPe Domain Sequences for d4mdsa1:

Sequence; same for both SEQRES and ATOM records: (download)

>d4mdsa1 b.47.1.4 (A:1-302) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {SARS coronavirus [TaxId: 227859]}

SCOPe Domain Coordinates for d4mdsa1:

Click to download the PDB-style file with coordinates for d4mdsa1.
(The format of our PDB-style files is described here.)

Timeline for d4mdsa1:

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