PDB entry 7k0g

View 7k0g on RCSB PDB site
Description: 1.85 A resolution structure of SARS-CoV 3CL protease in complex with deuterated GC376
Class: Hydrolase/Hydrolase Inhibitor
Keywords: PROTEASE, severe acute respiratory syndrome coronavirus, SARS 3CL protease Inhhibitors, hydrolase, deuterated hydrolase inhibitor, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2020-09-04, released 2021-07-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Replicase polyprotein 1a
    Species: Human SARS coronavirus [TaxId:694009]
    Gene: 1a
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6U8 (7-309)
      • expression tag (0-6)
    Domains in SCOPe 2.08: d7k0ga1, d7k0ga2
  • Heterogens: K36, B1S, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7k0gA (A:)
mhhhhhhsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpn
yedllirksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfs
vlacyngspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvha
gtdlegkfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlv
amkynyepltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftp
fdvvrqcsgv

    Sequence, based on observed residues (ATOM records): (download) 
    >7k0gA (A:)
hhsgfrkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedll
irksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacy
ngspsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdle
gkfygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflftttlndfnlvamkynye
pltqdhvdilgplsaqtgiavldmcaalkellqngtilgstiledeftpfdvvrqc