SCOPe 2.08: Domain d7m8mb_: 7m8m B:

Lineage for d7m8mb_ (7m8m B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 proteins)

6. Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (8 species)
   contains an extra alpha-helical domain

7. Species Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049] [385979] (354 PDB entries)

8. Domain d7m8mb_: 7m8m B: [405599]
   automated match to d3ea8a_
   complexed with ysg
   has additional subdomain(s) that are not in the common domain

Details for d7m8mb_

PDB Entry: 7m8m, 1.78 Å

PDB Description: crystal structure of the sars-cov-2(2019-ncov) main protease in complex with compound 11

PDB Compounds: (B:) 3C-like proteinase

SCOPe Domain Sequences for d7m8mb_:

Sequence; same for both SEQRES and ATOM records:

>d7m8mb_ b.47.1.4 (B:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {Severe acute respiratory syndrome coronavirus 2 [TaxId: 2697049]}
sgfrkmafpsgkvegcmvqvtcgtttlnglwlddvvycprhvictsedmlnpnyedllir
ksnhnflvqagnvqlrvighsmqncvlklkvdtanpktpkykfvriqpgqtfsvlacyng
spsgvyqcamrpnftikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegn
fygpfvdrqtaqaagtdttitvnvlawlyaavingdrwflnrftttlndfnlvamkynye
pltqdhvdilgplsaqtgiavldmcaslkellqngmngrtilgsalledeftpfdvvrqc
sgv

Timeline for d7m8mb_:

• d7m8mb_ first appeared in SCOPe 2.07