SCOPe 2.08: Domain d6xhob_: 6xho B:

Lineage for d6xhob_ (6xho B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (5 proteins)

6. Protein Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) [74979] (8 species)
   contains an extra alpha-helical domain

7. Species SARS coronavirus [TaxId:227859] [89349] (86 PDB entries)

8. Domain d6xhob_: 6xho B: [389088]
   automated match to d1z1ja_
   complexed with edo, v34
   has additional subdomain(s) that are not in the common domain

Details for d6xhob_

PDB Entry: 6xho, 1.45 Å

PDB Description: covalent complex of sars-cov main protease with ethyl (4r)-4-({n-[(4- methoxy-1h-indol-2-yl)carbonyl]-l-leucyl}amino)-5-[(3s)-2- oxopyrrolidin-3-yl]pentanoate

PDB Compounds: (B:) 3C-like proteinase

SCOPe Domain Sequences for d6xhob_:

Sequence, based on SEQRES records:

>d6xhob_ b.47.1.4 (B:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {SARS coronavirus [TaxId: 227859]}
frkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedllirks
nhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyngsp
sgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegkfy
gpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynyepl
tqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrqc

Sequence, based on observed residues (ATOM records):

>d6xhob_ b.47.1.4 (B:) Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) {SARS coronavirus [TaxId: 227859]}
frkmafpsgkvegcmvqvtcgtttlnglwlddtvycprhvictaedmlnpnyedllirks
nhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyngsp
sgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegkfy
gpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynyepl
tqdhvdilgplsaqtgiavldmcaalkellqngtilgstiledeftpfdvvrqc

Timeline for d6xhob_:

• d6xhob_ first appeared in SCOPe 2.07