Lineage for Protein: Tumor necrosis factor (TNF)

  1. Root: SCOPe 2.08
  2. Class b: All beta proteins [48724] (180 folds)
  3. Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. Family b.22.1.1: TNF-like [49843] (15 proteins)
  6. Protein Tumor necrosis factor (TNF) [49848] (2 species)

Species:

  1. Human (Homo sapiens) [TaxId:9606] [49849] (33 PDB entries)
    1. Domains for 1a8m:
      1. Domain d1a8ma_: 1a8m A: [23868]
        mutant
      2. Domain d1a8mb_: 1a8m B: [23869]
        mutant
      3. Domain d1a8mc_: 1a8m C: [23870]
        mutant
    2. Domains for 1tnf:
      1. Domain d1tnfa_: 1tnf A: [23871]
      2. Domain d1tnfb_: 1tnf B: [23872]
      3. Domain d1tnfc_: 1tnf C: [23873]
    3. Domain for 1tnr:
    4. Domains for 2az5:
      1. Domain d2az5a_: 2az5 A: [127599]
        automated match to d1tnfa_
        complexed with 307
      2. Domain d2az5b_: 2az5 B: [127600]
        automated match to d1tnfa_
        complexed with 307
      3. Domain d2az5c_: 2az5 C: [127601]
        automated match to d1tnfa_
        complexed with 307
      4. Domain d2az5d_: 2az5 D: [127602]
        automated match to d1tnfa_
        complexed with 307
    5. Domains for 2tun:
      1. Domain d2tuna_: 2tun A: [23874]
        mutant
      2. Domain d2tunb_: 2tun B: [23875]
        mutant
      3. Domain d2tunc_: 2tun C: [23876]
        mutant
      4. Domain d2tund_: 2tun D: [23877]
        mutant
      5. Domain d2tune_: 2tun E: [23878]
        mutant
      6. Domain d2tunf_: 2tun F: [23879]
        mutant
    6. Domains for 2zjc:
      1. Domain d2zjca_: 2zjc A: [171243]
        automated match to d1a8ma_
        complexed with gol; mutant
      2. Domain d2zjcb_: 2zjc B: [171244]
        automated match to d1a8ma_
        complexed with gol; mutant
      3. Domain d2zjcc_: 2zjc C: [171245]
        automated match to d1a8ma_
        complexed with gol; mutant
    7. Domains for 2zpx:
      1. Domain d2zpxa_: 2zpx A: [171412]
        automated match to d1a8ma_
        mutant
      2. Domain d2zpxb_: 2zpx B: [171413]
        automated match to d1a8ma_
        mutant
      3. Domain d2zpxc_: 2zpx C: [171414]
        automated match to d1a8ma_
        mutant
    8. Domains for 3alq:
      1. Domain d3alqa_: 3alq A: [245160]
        automated match to d1a8ma_
        complexed with co
      2. Domain d3alqb_: 3alq B: [245161]
        automated match to d1a8ma_
        complexed with co
      3. Domain d3alqc_: 3alq C: [245162]
        automated match to d1a8ma_
        complexed with co
      4. Domain d3alqd_: 3alq D: [245163]
        automated match to d1a8ma_
        complexed with co
      5. Domain d3alqe_: 3alq E: [245164]
        automated match to d1a8ma_
        complexed with co
      6. Domain d3alqf_: 3alq F: [245165]
        automated match to d1a8ma_
        complexed with co
    9. Domain for 3l9j:
    10. Domain for 3wd5:
    11. Domain for 4g3y:
    12. Domain for 4tsv:
    13. Domains for 4tsw:
      1. Domain d4tswa_: 4tsw A: [309664]
        automated match to d5tswa_
        mutant
      2. Domain d4tswb_: 4tsw B: [309665]
        automated match to d5tswa_
        mutant
      3. Domain d4tswc_: 4tsw C: [309666]
        automated match to d5tswa_
        mutant
      4. Domain d4tswd_: 4tsw D: [309667]
        automated match to d5tswa_
        mutant
      5. Domain d4tswe_: 4tsw E: [309668]
        automated match to d5tswa_
        mutant
      6. Domain d4tswf_: 4tsw F: [309669]
        automated match to d5tswa_
        mutant
    14. Domains for 5m2i:
      1. Domain d5m2ia_: 5m2i A: [338539]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
      2. Domain d5m2ib_: 5m2i B: [338554]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
      3. Domain d5m2ic_: 5m2i C: [338538]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
      4. Domain d5m2id_: 5m2i D: [338540]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
      5. Domain d5m2ie_: 5m2i E: [338542]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
      6. Domain d5m2if_: 5m2i F: [338541]
        Other proteins in same PDB: d5m2ig_, d5m2ih_, d5m2ii_, d5m2ij_, d5m2ik_, d5m2il_
        automated match to d1a8ma_
    15. Domain for 5m2j:
    16. Domains for 5m2m:
      1. Domain d5m2ma_: 5m2m A: [338556]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
      2. Domain d5m2mb_: 5m2m B: [338555]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
      3. Domain d5m2mc_: 5m2m C: [338525]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
      4. Domain d5m2mg_: 5m2m G: [338616]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
      5. Domain d5m2mi_: 5m2m I: [338533]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
      6. Domain d5m2mm_: 5m2m M: [338552]
        Other proteins in same PDB: d5m2md1, d5m2md2, d5m2me1, d5m2me2, d5m2mf1, d5m2mf2, d5m2mh1, d5m2mh2, d5m2mj1, d5m2mj2, d5m2mn1, d5m2mn2
        automated match to d1a8ma_
    17. Domains for 5mu8:
      1. Domain d5mu8a_: 5mu8 A: [332502]
        automated match to d1a8ma_
        complexed with jni
      2. Domain d5mu8b_: 5mu8 B: [332482]
        automated match to d1a8ma_
        complexed with jni
      3. Domain d5mu8c_: 5mu8 C: [332470]
        automated match to d1a8ma_
        complexed with jni
      4. Domain d5mu8d_: 5mu8 D: [332413]
        automated match to d1a8ma_
        complexed with jni
      5. Domain d5mu8e_: 5mu8 e: [332515]
        automated match to d1a8ma_
        complexed with jni
      6. Domain d5mu8f_: 5mu8 F: [332415]
        automated match to d1a8ma_
        complexed with jni
      7. Domain d5mu8g_: 5mu8 G: [332520]
        automated match to d1a8ma_
        complexed with jni
      8. Domain d5mu8h_: 5mu8 H: [332513]
        automated match to d1a8ma_
        complexed with jni
      9. Domain d5mu8i_: 5mu8 I: [332417]
        automated match to d1a8ma_
        complexed with jni
      10. Domain d5mu8j_: 5mu8 J: [332469]
        automated match to d1a8ma_
        complexed with jni
      11. Domain d5mu8k_: 5mu8 K: [332516]
        automated match to d1a8ma_
        complexed with jni
      12. Domain d5mu8l_: 5mu8 L: [332481]
        automated match to d1a8ma_
        complexed with jni
      13. Domain d5mu8m_: 5mu8 M: [332512]
        automated match to d1a8ma_
        complexed with jni
      14. Domain d5mu8n_: 5mu8 N: [332479]
        automated match to d1a8ma_
        complexed with jni
      15. Domain d5mu8o_: 5mu8 O: [332426]
        automated match to d1a8ma_
        complexed with jni
      16. Domain d5mu8p_: 5mu8 P: [332514]
        automated match to d1a8ma_
        complexed with jni
      17. Domain d5mu8q_: 5mu8 Q: [332486]
        automated match to d1a8ma_
        complexed with jni
      18. Domain d5mu8r_: 5mu8 R: [332425]
        automated match to d1a8ma_
        complexed with jni
      19. Domain d5mu8s_: 5mu8 S: [332414]
        automated match to d1a8ma_
        complexed with jni
      20. Domain d5mu8t_: 5mu8 T: [332519]
        automated match to d1a8ma_
        complexed with jni
      21. Domain d5mu8u_: 5mu8 U: [332476]
        automated match to d1a8ma_
        complexed with jni
      22. Domain d5mu8v_: 5mu8 V: [332418]
        automated match to d1a8ma_
        complexed with jni
      23. Domain d5mu8w_: 5mu8 W: [332451]
        automated match to d1a8ma_
        complexed with jni
      24. Domain d5mu8x_: 5mu8 X: [332521]
        automated match to d1a8ma_
        complexed with jni
      25. Domain d5mu8y_: 5mu8 Y: [332466]
        automated match to d1a8ma_
        complexed with jni
      26. Domain d5mu8z_: 5mu8 Z: [332420]
        automated match to d1a8ma_
        complexed with jni
    18. Domains for 5tsw:
      1. Domain d5tswa_: 5tsw A: [23861]
        mutant
      2. Domain d5tswb_: 5tsw B: [23862]
        mutant
      3. Domain d5tswc_: 5tsw C: [23863]
        mutant
      4. Domain d5tswd_: 5tsw D: [23864]
        mutant
      5. Domain d5tswe_: 5tsw E: [23865]
        mutant
      6. Domain d5tswf_: 5tsw F: [23866]
        mutant
    19. Domain for 5uui:
    20. Domains for 5yoy:
      1. Domain d5yoya1: 5yoy A:6-157 [351963]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
      2. Domain d5yoyb1: 5yoy B:6-157 [352018]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
      3. Domain d5yoyc1: 5yoy C:6-157 [352001]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
      4. Domain d5yoyj1: 5yoy J:6-157 [351958]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
      5. Domain d5yoyk1: 5yoy K:6-157 [351954]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
      6. Domain d5yoyl1: 5yoy L:6-157 [351956]
        Other proteins in same PDB: d5yoya2, d5yoyb2, d5yoyc2, d5yoyd_, d5yoye_, d5yoyf_, d5yoyg_, d5yoyh_, d5yoyi_, d5yoyj2, d5yoyk2, d5yoyl2, d5yoym_, d5yoyn_, d5yoyo_, d5yoyp_, d5yoyq_, d5yoyr_
        automated match to d1a8ma_
    21. Domains for 6ooy:
      1. Domain d6ooya_: 6ooy A: [378602]
        automated match to d1a8ma_
        complexed with a7m, mrd
      2. Domain d6ooyb_: 6ooy B: [378620]
        automated match to d1a8ma_
        complexed with a7m, mrd
      3. Domain d6ooyc_: 6ooy C: [378608]
        automated match to d1a8ma_
        complexed with a7m, mrd
    22. Domains for 6ooz:
      1. Domain d6ooza_: 6ooz A: [378622]
        automated match to d1a8ma_
        complexed with a6y, cl
      2. Domain d6oozb_: 6ooz B: [378610]
        automated match to d1a8ma_
        complexed with a6y, cl
      3. Domain d6oozc_: 6ooz C: [378597]
        automated match to d1a8ma_
        complexed with a6y, cl
    23. Domains for 6op0:
      1. Domain d6op0a_: 6op0 A: [378605]
        automated match to d1a8ma_
        complexed with a7a
      2. Domain d6op0b_: 6op0 B: [378606]
        automated match to d1a8ma_
        complexed with a7a
      3. Domain d6op0c_: 6op0 C: [378603]
        automated match to d1a8ma_
        complexed with a7a
    24. Domains for 6rmj:
      1. Domain d6rmja_: 6rmj A: [375835]
        automated match to d1a8ma_
      2. Domain d6rmjb_: 6rmj B: [375836]
        automated match to d1a8ma_
      3. Domain d6rmjc_: 6rmj C: [375857]
        automated match to d1a8ma_
    25. Domains for 6x81:
      1. Domain d6x81a_: 6x81 A: [401021]
        automated match to d1a8ma_
        complexed with utj
      2. Domain d6x81b_: 6x81 B: [401078]
        automated match to d1a8ma_
        complexed with utj
      3. Domain d6x81c_: 6x81 C: [401036]
        automated match to d1a8ma_
        complexed with utj
      4. Domain d6x81d_: 6x81 D: [401018]
        automated match to d1a8ma_
        complexed with utj
      5. Domain d6x81e_: 6x81 E: [401105]
        automated match to d1a8ma_
        complexed with utj
      6. Domain d6x81f_: 6x81 F: [401034]
        automated match to d1a8ma_
        complexed with utj
    26. Domains for 6x82:
      1. Domain d6x82a_: 6x82 A: [401040]
        automated match to d1a8ma_
        complexed with utm
      2. Domain d6x82b_: 6x82 B: [401038]
        automated match to d1a8ma_
        complexed with utm
      3. Domain d6x82c_: 6x82 C: [401026]
        automated match to d1a8ma_
        complexed with utm
      4. Domain d6x82d_: 6x82 D: [401037]
        automated match to d1a8ma_
        complexed with utm
      5. Domain d6x82e_: 6x82 E: [401031]
        automated match to d1a8ma_
        complexed with utm
      6. Domain d6x82f_: 6x82 F: [401035]
        automated match to d1a8ma_
        complexed with utm
    27. Domains for 6x83:
      1. Domain d6x83a_: 6x83 A: [401046]
        automated match to d1a8ma_
        complexed with uts
      2. Domain d6x83b_: 6x83 B: [401056]
        automated match to d1a8ma_
        complexed with uts
      3. Domain d6x83c_: 6x83 C: [401052]
        automated match to d1a8ma_
        complexed with uts
      4. Domain d6x83d_: 6x83 D: [401058]
        automated match to d1a8ma_
        complexed with uts
      5. Domain d6x83e_: 6x83 E: [401055]
        automated match to d1a8ma_
        complexed with uts
      6. Domain d6x83f_: 6x83 F: [401061]
        automated match to d1a8ma_
        complexed with uts
    28. Domains for 6x85:
      1. Domain d6x85a_: 6x85 A: [401051]
        automated match to d1a8ma_
        complexed with utv
      2. Domain d6x85b_: 6x85 B: [401032]
        automated match to d1a8ma_
        complexed with utv
      3. Domain d6x85c_: 6x85 C: [401096]
        automated match to d1a8ma_
        complexed with utv
      4. Domain d6x85d_: 6x85 D: [401027]
        automated match to d1a8ma_
        complexed with utv
      5. Domain d6x85e_: 6x85 E: [401022]
        automated match to d1a8ma_
        complexed with utv
      6. Domain d6x85f_: 6x85 F: [401060]
        automated match to d1a8ma_
        complexed with utv
    29. Domains for 6x86:
      1. Domain d6x86a_: 6x86 A: [401057]
        automated match to d1a8ma_
        complexed with uty
      2. Domain d6x86b_: 6x86 B: [401059]
        automated match to d1a8ma_
        complexed with uty
      3. Domain d6x86c_: 6x86 C: [401095]
        automated match to d1a8ma_
        complexed with uty
      4. Domain d6x86d_: 6x86 D: [401045]
        automated match to d1a8ma_
        complexed with uty
      5. Domain d6x86e_: 6x86 E: [401041]
        automated match to d1a8ma_
        complexed with uty
      6. Domain d6x86f_: 6x86 F: [401054]
        automated match to d1a8ma_
        complexed with uty
    30. Domains for 7jra:
      1. Domain d7jraa_: 7jra A: [394561]
        automated match to d1a8ma_
        complexed with gol, vgy
      2. Domain d7jrab_: 7jra B: [394565]
        automated match to d1a8ma_
        complexed with gol, vgy
      3. Domain d7jrac_: 7jra C: [394554]
        automated match to d1a8ma_
        complexed with gol, vgy
    31. Domains for 7kp9:
      1. Domain d7kp9a_: 7kp9 A: [399401]
        automated match to d1a8ma_
        complexed with a7g
      2. Domain d7kp9b_: 7kp9 B: [399348]
        automated match to d1a8ma_
        complexed with a7g
      3. Domain d7kp9c_: 7kp9 C: [399396]
        automated match to d1a8ma_
        complexed with a7g
    32. Domains for 7kpa:
      1. Domain d7kpaa_: 7kpa A: [399297]
        automated match to d1a8ma_
        complexed with d84
      2. Domain d7kpab_: 7kpa B: [399315]
        automated match to d1a8ma_
        complexed with d84
      3. Domain d7kpac_: 7kpa C: [399351]
        automated match to d1a8ma_
        complexed with d84
    33. Domains for 7kpb:
      1. Domain d7kpba_: 7kpb A: [399362]
        Other proteins in same PDB: d7kpbh_, d7kpbl1, d7kpbl2
        automated match to d1a8ma_
        complexed with d84, gol, nag
      2. Domain d7kpbb_: 7kpb B: [399334]
        Other proteins in same PDB: d7kpbh_, d7kpbl1, d7kpbl2
        automated match to d1a8ma_
        complexed with d84, gol, nag
      3. Domain d7kpbc_: 7kpb C: [399370]
        Other proteins in same PDB: d7kpbh_, d7kpbl1, d7kpbl2
        automated match to d1a8ma_
        complexed with d84, gol, nag
  2. Mouse (Mus musculus) [TaxId:10090] [49850] (3 PDB entries)
    1. Domains for 2tnf:
      1. Domain d2tnfa_: 2tnf A: [23880]
        complexed with ipa, trs
      2. Domain d2tnfb_: 2tnf B: [23881]
        complexed with ipa, trs
      3. Domain d2tnfc_: 2tnf C: [23882]
        complexed with ipa, trs
    2. Domains for 7kp7:
      1. Domain d7kp7a_: 7kp7 A: [399406]
        automated match to d2tnfa_
        complexed with nag, so4
      2. Domain d7kp7b_: 7kp7 B: [399314]
        automated match to d2tnfa_
        complexed with nag, so4
      3. Domain d7kp7c_: 7kp7 C: [399328]
        automated match to d2tnfa_
        complexed with nag, so4
    3. Domains for 7kp8:
      1. Domain d7kp8a_: 7kp8 A: [399324]
        automated match to d2tnfa_
        complexed with a7g
      2. Domain d7kp8b_: 7kp8 B: [399291]
        automated match to d2tnfa_
        complexed with a7g
      3. Domain d7kp8c_: 7kp8 C: [399307]
        automated match to d2tnfa_
        complexed with a7g

More info for Protein Tumor necrosis factor (TNF) from b.22.1.1: TNF-like

Timeline for Protein Tumor necrosis factor (TNF) from b.22.1.1: TNF-like: