PDB entry 6x85

View 6x85 on RCSB PDB site
Description: Crystal Structure of TNFalpha with indolinone compound 9
Class: cytokine
Keywords: Trimer, inhibitor complex, CYTOKINE
Deposited on 2020-06-01, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85a_
  • Chain 'B':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85b_
  • Chain 'C':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85c_
  • Chain 'D':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85d_
  • Chain 'E':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85e_
  • Chain 'F':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x85f_
  • Heterogens: UTV

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6x85A (A:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85A (A:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisriavtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x85B (B:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85B (B:)
kpvahvvanpqaegqlqwlnrgvelrdnqlvvpseglyliysqvlfkgqgcpsthvllth
tisriavsyqtkvnllsaikspcqkpwyepiylggvfqlekgdrlsaeinrpdyldfaes
gqvyfgiial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6x85C (C:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85C (C:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisriavsyqtkvnllsaikspcqreakpwyepiylggvfqlekgdrl
saeinrpdyldfaesgqvyfgiial

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6x85D (D:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85D (D:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisriavsnllsaikspcqrkpwyepiylggvfqlekgdrlsaeinrp
dyldfaesgqvyfgiial

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6x85E (E:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85E (E:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavskvnllsaikspcqkpwyepiylggvfqlekgdrlsaeinrpdy
ldfaesgqvyfgiial

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6x85F (F:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x85F (F:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisriavsyqtkvnllsaikspcqreakpwyepiylggvfqlekgdrl
saeinrpdyldfaesgqvyfgiial