Lineage for d2az5b_ (2az5 B:)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2372079Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. 2372080Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. 2372081Family b.22.1.1: TNF-like [49843] (15 proteins)
  6. 2372278Protein Tumor necrosis factor (TNF) [49848] (2 species)
  7. 2372279Species Human (Homo sapiens) [TaxId:9606] [49849] (20 PDB entries)
  8. 2372283Domain d2az5b_: 2az5 B: [127600]
    automated match to d1tnfa_
    complexed with 307

Details for d2az5b_

PDB Entry: 2az5 (more details), 2.1 Å

PDB Description: crystal structure of tnf-alpha with a small molecule inhibitor
PDB Compounds: (B:) Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

SCOPe Domain Sequences for d2az5b_:

Sequence, based on SEQRES records: (download)

>d2az5b_ b.22.1.1 (B:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

Sequence, based on observed residues (ATOM records): (download)

>d2az5b_ b.22.1.1 (B:) Tumor necrosis factor (TNF) {Human (Homo sapiens) [TaxId: 9606]}
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqrkpwyepiylggvfqlekgdrlsaein
rpdyldfaesgqvyfgiial

SCOPe Domain Coordinates for d2az5b_:

Click to download the PDB-style file with coordinates for d2az5b_.
(The format of our PDB-style files is described here.)

Timeline for d2az5b_: