PDB entry 6x81

View 6x81 on RCSB PDB site
Description: Crystal Structure of TNFalpha with isoquinoline compound 2
Class: cytokine
Keywords: Trimer, inhibitor complex, CYTOKINE
Deposited on 2020-06-01, released 2021-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81a_
  • Chain 'B':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81b_
  • Chain 'C':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81c_
  • Chain 'D':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81d_
  • Chain 'E':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81e_
  • Chain 'F':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6x81f_
  • Heterogens: UTJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6x81A (A:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81A (A:)
sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
cpsthvllthtisriavsyqtkvnllsaikspcqretpakpwyepiylggvfqlekgdrl
saeinrpdyldfaesgqvyfgiial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6x81B (B:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81B (B:)
sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
cpsthvllthtisriavsyqtkvnllsaikspcqretaeakpwyepiylggvfqlekgdr
lsaeinrpdyldfaesgqvyfgiial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6x81C (C:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81C (C:)
psdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgq
gcpsthvllthtisriavsyqtkvnllsaikspcqreakpwyepiylggvfqlekgdrls
aeinrpdyldfaesgqvyfgiial

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6x81D (D:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81D (D:)
psdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgq
gcpsthvllthtisriavsyqtkvnllsaikspcqkpwyepiylggvfqlekgdrlsaei
nrpdyldfaesgqvyfgiial

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6x81E (E:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81E (E:)
kpvahvvanpqaegqlqwlnrrngvelrdnqlvvpseglyliysqvlfkgqgcpsthvll
thtisriavsyqtkvnllsaikspcakpwyepiylggvfqlekgdrlsaeinrpdyldfa
esgqvyfgiial

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6x81F (F:)
mvrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >6x81F (F:)
tpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkg
qgcpsthvllthtisriavsyqtkvnllsaikspcqrakpwyepiylggvfqlekgdrls
aeinrpdyldfaesgqvyfgiial