PDB entry 3l9j
View 3l9j on RCSB PDB site
Description: Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
Class: immune system
Keywords: TNF-alpha, antagonist, in vitro selection, Cell membrane, Cytokine, Disulfide bond, Glycoprotein, Lipoprotein, Secreted, Signal-anchor, Transmembrane, IMMUNE SYSTEM
Deposited on
2010-01-05, released
2010-02-23
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-01-31, with a file datestamp of
2018-01-26.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'C':
Compound: TNFalpha
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3l9jc_ - Chain 'T':
Compound: Tumor necrosis factor, soluble form
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3l9jt_ - Heterogens: MG, HOH
PDB Chain Sequences:
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3l9jC (C:)
lqtvclkgtkhmkcflaftqtktfheasedcisrggtlstpqtgsendalyeylrqsvgn
eaeiwlglnkrwsryfwvdmtgtriayknwehssdaqpdpsnwencavlsgaangkwfgk
rcrdqlpyicqfgi
Sequence, based on observed residues (ATOM records): (download)
>3l9jC (C:)
lqtvclhmkcflaftqtktfheasedcisrggtlstpqtgsendalyeylrqsvgneaei
wlglnkrwsryfwvdmtgtriayknwehssdaqpdpsnwencavlsgaangkwfgkrcrd
qlpyicqfgi
- Chain 'T':
Sequence; same for both SEQRES and ATOM records: (download)
>3l9jT (T:)
sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
cpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlek
gdrlsaeinrpdyldfaesgqvyfgiial