SCOPe 2.08: Protein: 3-isopropylmalate dehydrogenase, IPMDH

Lineage for Protein: 3-isopropylmalate dehydrogenase, IPMDH

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
consists of two intertwined (sub)domains related by pseudo dyad; duplication
3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
the constituent families form similar dimers
Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
the active site is between the two identical subunits
Protein 3-isopropylmalate dehydrogenase, IPMDH [53661] (11 species)

Species:

Bacillus coagulans [TaxId:1398] [53664] (2 PDB entries)
1. Domains for 1ayq:
  1. Domain d1ayqa_: 1ayq A: [302207]
    automated match to d2ayqb_
  2. Domain d1ayqb_: 1ayq B: [302208]
    automated match to d2ayqb_
2. Domains for 2ayq:
  1. Domain d2ayqa_: 2ayq A: [35057]
  2. Domain d2ayqb_: 2ayq B: [35058]
Bacillus sp. [TaxId:1409] [254872] (1 PDB entry)
- Domains for 3u1h:
  1. Domain d3u1ha_: 3u1h A: [233762]
    automated match to d3vmja_
  2. Domain d3u1hb_: 3u1h B: [262344]
    automated match to d3u1ha_
Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)
1. Domain for 1xac:
  - Domain d1xaca_: 1xac A: [35056]
2. Domain for 1xad:
  - Domain d1xada_: 1xad A: [35055]
Escherichia coli [TaxId:562] [53667] (1 PDB entry)
- Domains for 1cm7:
  1. Domain d1cm7a_: 1cm7 A: [35063]
  2. Domain d1cm7b_: 1cm7 B: [35064]
Mycobacterium tuberculosis [TaxId:1773] [117725] (2 PDB entries)
Uniprot P95313
1. Domains for 1w0d:
  1. Domain d1w0da1: 1w0d A:1A-336 [114060]
    Other proteins in same PDB: d1w0da2, d1w0db2, d1w0dc2, d1w0dd2
    complexed with so4
  2. Domain d1w0db1: 1w0d B:1A-336 [114061]
    Other proteins in same PDB: d1w0da2, d1w0db2, d1w0dc2, d1w0dd2
    complexed with so4
  3. Domain d1w0dc1: 1w0d C:1A-336 [114062]
    Other proteins in same PDB: d1w0da2, d1w0db2, d1w0dc2, d1w0dd2
    complexed with so4
  4. Domain d1w0dd1: 1w0d D:1A-336 [114063]
    Other proteins in same PDB: d1w0da2, d1w0db2, d1w0dc2, d1w0dd2
    complexed with so4
2. Domains for 2g4o:
  1. Domain d2g4oa2: 2g4o A:1A-336 [134604]
    Other proteins in same PDB: d2g4oa3, d2g4ob3, d2g4oc3, d2g4od3
    automated match to d1w0da_
    complexed with cl, so4
  2. Domain d2g4ob2: 2g4o B:1A-336 [134605]
    Other proteins in same PDB: d2g4oa3, d2g4ob3, d2g4oc3, d2g4od3
    automated match to d1w0da_
    complexed with cl, so4
  3. Domain d2g4oc2: 2g4o C:1A-336 [134606]
    Other proteins in same PDB: d2g4oa3, d2g4ob3, d2g4oc3, d2g4od3
    automated match to d1w0da_
    complexed with cl, so4
  4. Domain d2g4od2: 2g4o D:1A-336 [134607]
    Other proteins in same PDB: d2g4oa3, d2g4ob3, d2g4oc3, d2g4od3
    automated match to d1w0da_
    complexed with cl, so4
Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)
- Domains for 1cnz:
  1. Domain d1cnza_: 1cnz A: [35061]
    complexed with mn, so4
  2. Domain d1cnzb_: 1cnz B: [35062]
    complexed with mn, so4
Shewanella benthica [TaxId:43661] [195907] (1 PDB entry)
- Domains for 3vmk:
  1. Domain d3vmka1: 3vmk A:2-363 [197350]
    Other proteins in same PDB: d3vmka2, d3vmkb2
    automated match to d1cnza_
    complexed with cl, ipm, mg
  2. Domain d3vmkb1: 3vmk B:2-363 [195908]
    Other proteins in same PDB: d3vmka2, d3vmkb2
    automated match to d1cnza_
    complexed with cl, ipm, mg
Sulfolobus tokodaii [TaxId:111955] [117724] (1 PDB entry)
Uniprot P50455
- Domains for 1wpw:
  1. Domain d1wpwa_: 1wpw A: [114830]
    complexed with mg
  2. Domain d1wpwb_: 1wpw B: [114831]
    complexed with mg
Thermotoga maritima [TaxId:2336] [110714] (1 PDB entry)
Uniprot Q9WZ26
- Domain for 1vlc:
  - Domain d1vlca1: 1vlc A:1-354 [108743]
    Other proteins in same PDB: d1vlca2
    Structural genomics target
    complexed with cl
Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)
1. Domains for 1dpz:
  1. Domain d1dpza_: 1dpz A: [35053]
  2. Domain d1dpzb_: 1dpz B: [35054]
2. Domains for 1dr0:
  1. Domain d1dr0a_: 1dr0 A: [35045]
  2. Domain d1dr0b_: 1dr0 B: [35046]
3. Domains for 1dr8:
  1. Domain d1dr8a_: 1dr8 A: [35051]
  2. Domain d1dr8b_: 1dr8 B: [35052]
4. Domain for 1g2u:
  - Domain d1g2ua_: 1g2u A: [35036]
    mutant
5. Domains for 1gc8:
  1. Domain d1gc8a_: 1gc8 A: [35042]
  2. Domain d1gc8b_: 1gc8 B: [35043]
6. Domain for 1gc9:
  - Domain d1gc9a_: 1gc9 A: [35037]
7. Domain for 1hex:
  - Domain d1hexa_: 1hex A: [35044]
    complexed with nad
8. Domain for 1idm:
  - Domain d1idma_: 1idm A: [35035]
9. Domain for 1ipd:
  - Domain d1ipda_: 1ipd A: [35038]
    complexed with so4
10. Domains for 1osi:
  1. Domain d1osia_: 1osi A: [35047]
  2. Domain d1osib_: 1osi B: [35048]
  3. Domain d1osic_: 1osi C: [35049]
  4. Domain d1osid_: 1osi D: [35050]
11. Domains for 1osj:
  1. Domain d1osja_: 1osj A: [35039]
  2. Domain d1osjb_: 1osj B: [35040]
12. Domain for 1wal:
  - Domain d1wala_: 1wal A: [35041]
    mutant
13. Domain for 1xaa:
  - Domain d1xaaa_: 1xaa A: [35033]
14. Domain for 1xab:
  - Domain d1xaba_: 1xab A: [35034]
Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)
- Domains for 1a05:
  1. Domain d1a05a_: 1a05 A: [35059]
    complexed with ipm, mg
  2. Domain d1a05b_: 1a05 B: [35060]
    complexed with ipm, mg

More info for Protein 3-isopropylmalate dehydrogenase, IPMDH from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Protein 3-isopropylmalate dehydrogenase, IPMDH from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases:

Protein 3-isopropylmalate dehydrogenase, IPMDH from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases first appeared (with stable ids) in SCOP 1.55, called Protein 3-isopropylmalate dehydrogenase, IPMDH from c.77.1.1: Isocitrate & isopropylmalate dehydrogenases
Protein 3-isopropylmalate dehydrogenase, IPMDH from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.07