Lineage for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers

Families:

  1. 2138634c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits
  2. 2138891c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 protein domains)
    the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
    automatically mapped to Pfam PF03971
  3. 2138904c.77.1.3: PdxA-like [102656] (2 protein domains)
    Pfam PF04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
  4. 2138924c.77.1.4: PlsX-like [102660] (1 protein)
    Pfam PF02504; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and phosphotransacetylase families
  5. 2138932c.77.1.5: Phosphotransacetylase [102663] (3 protein domains)
    Pfam PF01515; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and PlsX-like families
  6. 2138965c.77.1.0: automated matches [191423] (1 protein)
    not a true family

More info for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like

Timeline for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like: