Lineage for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138634Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits

Protein Domains:

  1. 21386353-isopropylmalate dehydrogenase, IPMDH [53661] (11 species)
    1. 2138636Species Bacillus coagulans [TaxId:1398] [53664] (2 PDB entries)
    2. 2138641Species Bacillus sp. [TaxId:1409] [254872] (1 PDB entry)
    3. 2138644Species Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)
    4. 2138647Species Escherichia coli [TaxId:562] [53667] (1 PDB entry)
    5. 2138650Species Mycobacterium tuberculosis [TaxId:1773] [117725] (2 PDB entries)
      Uniprot P95313
    6. 2138659Species Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)
    7. 2138662Species Shewanella benthica [TaxId:43661] [195907] (1 PDB entry)
    8. 2138665Species Sulfolobus tokodaii [TaxId:111955] [117724] (1 PDB entry)
      Uniprot P50455
    9. 2138668Species Thermotoga maritima [TaxId:2336] [110714] (1 PDB entry)
      Uniprot Q9WZ26
    10. 2138670Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)
    11. 2138693Species Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)
  2. 2138696Isocitrate dehydrogenase, ICDH [53668] (2 species)
    1. 2138697Species Bacillus subtilis [TaxId:1423] [64171] (1 PDB entry)
    2. 2138700Species Escherichia coli [TaxId:562] [53669] (27 PDB entries)
  3. 2138728NADP-dependent isocitrate dehydrogenase [82524] (2 species)
    1. 2138729Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
      Uniprot O75874
    2. 2138761Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
  4. 2138768automated matches [190072] (19 species)
    not a true protein
    1. 2138769Species Acidithiobacillus thiooxidans [TaxId:930] [187607] (1 PDB entry)
    2. 2138774Species Archaeoglobus fulgidus [TaxId:2234] [187335] (1 PDB entry)
    3. 2138777Species Bacillus coagulans [TaxId:1398] [186792] (2 PDB entries)
    4. 2138788Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [225478] (4 PDB entries)
    5. 2138811Species Burkholderia pseudomallei [TaxId:28450] [188497] (1 PDB entry)
    6. 2138813Species Burkholderia thailandensis [TaxId:271848] [193254] (1 PDB entry)
    7. 2138816Species Campylobacter jejuni [TaxId:197] [189804] (2 PDB entries)
    8. 2138826Species Escherichia coli K-12 [TaxId:83333] [189313] (1 PDB entry)
    9. 2138829Species Escherichia coli [TaxId:562] [193425] (5 PDB entries)
    10. 2138835Species Escherichia coli [TaxId:833333] [194427] (1 PDB entry)
    11. 2138837Species Human (Homo sapiens) [TaxId:9606] [189131] (7 PDB entries)
    12. 2138844Species Mouse (Mus musculus) [TaxId:10090] [187557] (3 PDB entries)
    13. 2138849Species Mycobacterium tuberculosis [TaxId:1773] [193947] (1 PDB entry)
    14. 2138852Species Shewanella oneidensis [TaxId:211586] [194175] (12 PDB entries)
    15. 2138865Species Sinorhizobium meliloti [TaxId:266834] [226269] (1 PDB entry)
    16. 2138868Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [256054] (2 PDB entries)
    17. 2138873Species Thermus thermophilus HB8 [TaxId:300852] [192453] (1 PDB entry)
    18. 2138878Species Thermus thermophilus [TaxId:274] [189081] (6 PDB entries)
    19. 2268475Species Sulfolobus acidocaldarius [TaxId:330779] [311781] (1 PDB entry)

More info for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: