Lineage for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2905791Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2905792Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2905793Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
    the active site is between the two identical subunits

Proteins:

  1. 29057943-isopropylmalate dehydrogenase, IPMDH [53661] (11 species)
    1. 2905795Species Bacillus coagulans [TaxId:1398] [53664] (2 PDB entries)
    2. 2905800Species Bacillus sp. [TaxId:1409] [254872] (1 PDB entry)
    3. 2905803Species Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)
    4. 2905806Species Escherichia coli [TaxId:562] [53667] (1 PDB entry)
    5. 2905809Species Mycobacterium tuberculosis [TaxId:1773] [117725] (2 PDB entries)
      Uniprot P95313
    6. 2905818Species Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)
    7. 2905821Species Shewanella benthica [TaxId:43661] [195907] (1 PDB entry)
    8. 2905824Species Sulfolobus tokodaii [TaxId:111955] [117724] (1 PDB entry)
      Uniprot P50455
    9. 2905827Species Thermotoga maritima [TaxId:2336] [110714] (1 PDB entry)
      Uniprot Q9WZ26
    10. 2905829Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)
    11. 2905852Species Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)
  2. 2905855Isocitrate dehydrogenase, ICDH [53668] (2 species)
    1. 2905856Species Bacillus subtilis [TaxId:1423] [64171] (1 PDB entry)
    2. 2905859Species Escherichia coli [TaxId:562] [53669] (27 PDB entries)
  3. 2905887NADP-dependent isocitrate dehydrogenase [82524] (2 species)
    1. 2905888Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
      Uniprot O75874
    2. 2905983Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
  4. 2905990automated matches [190072] (22 species)
    not a true protein
    1. 2905991Species Acidithiobacillus thiooxidans [TaxId:930] [187607] (1 PDB entry)
    2. 2905996Species Archaeoglobus fulgidus [TaxId:2234] [187335] (1 PDB entry)
    3. 2905999Species Bacillus coagulans [TaxId:1398] [186792] (2 PDB entries)
    4. 2906010Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [225478] (4 PDB entries)
    5. 2906033Species Burkholderia pseudomallei [TaxId:28450] [188497] (1 PDB entry)
    6. 2906035Species Burkholderia thailandensis [TaxId:271848] [193254] (1 PDB entry)
    7. 2906038Species Campylobacter jejuni [TaxId:197] [189804] (2 PDB entries)
    8. 2906048Species Escherichia coli K-12 [TaxId:83333] [189313] (1 PDB entry)
    9. 2906051Species Escherichia coli [TaxId:562] [193425] (5 PDB entries)
    10. 2906057Species Escherichia coli [TaxId:833333] [194427] (1 PDB entry)
    11. 2906059Species Haemophilus influenzae [TaxId:71421] [381589] (1 PDB entry)
    12. 2906062Species Human (Homo sapiens) [TaxId:9606] [189131] (10 PDB entries)
    13. 2906083Species Mouse (Mus musculus) [TaxId:10090] [187557] (3 PDB entries)
    14. 2906090Species Mycobacterium tuberculosis [TaxId:1773] [193947] (1 PDB entry)
    15. 2906093Species Shewanella oneidensis [TaxId:211586] [194175] (12 PDB entries)
    16. 2906106Species Sinorhizobium meliloti [TaxId:266834] [226269] (1 PDB entry)
    17. 2906109Species Sulfolobus acidocaldarius [TaxId:330779] [311781] (1 PDB entry)
    18. 2906112Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [256054] (2 PDB entries)
    19. 2906121Species Thermus thermophilus HB8 [TaxId:300852] [192453] (1 PDB entry)
    20. 2906126Species Thermus thermophilus [TaxId:274] [189081] (6 PDB entries)
    21. 2906139Species Trypanosoma brucei [TaxId:5702] [373328] (3 PDB entries)
    22. 2906150Species Trypanosoma cruzi [TaxId:353153] [373333] (1 PDB entry)

More info for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: