Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudo dyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) the constituent families form similar dimers |
Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins) the active site is between the two identical subunits |
Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species) |
Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries) Uniprot O75874 |
Domain d1t09a_: 1t09 A: [106197] complexed with nap |
Domain d1t09b_: 1t09 B: [106198] complexed with nap |
Domain d1t0la_: 1t0l A: [106216] complexed with ca, ict, nap |
Domain d1t0lb_: 1t0l B: [106217] complexed with ca, ict, nap |
Domain d1t0lc_: 1t0l C: [106218] complexed with ca, ict, nap |
Domain d1t0ld_: 1t0l D: [106219] complexed with ca, ict, nap |
Domain d3inma_: 3inm A: [178460] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
Domain d3inmb_: 3inm B: [178461] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
Domain d3inmc_: 3inm C: [178462] automated match to d1t09a_ protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant |
Domain d3mapa_: 3map A: [180990] automated match to d1t09a_ complexed with ict, nap; mutant |
Domain d3mapb_: 3map B: [180991] automated match to d1t09a_ complexed with ict, nap; mutant |
Domain d4kzoa1: 4kzo A:3-414 [224533] Other proteins in same PDB: d4kzoa2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4kzob_: 4kzo B: [224534] Other proteins in same PDB: d4kzoa2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4kzoc_: 4kzo C: [224535] Other proteins in same PDB: d4kzoa2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4l03a1: 4l03 A:3-414 [224536] Other proteins in same PDB: d4l03a2, d4l03c2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4l03b_: 4l03 B: [224537] Other proteins in same PDB: d4l03a2, d4l03c2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4l03c1: 4l03 C:3-414 [224538] Other proteins in same PDB: d4l03a2, d4l03c2 automated match to d3inmb_ complexed with akg, ca, edo, nap; mutant |
Domain d4l04a1: 4l04 A:5-414 [240460] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d4l04b_ complexed with akg, ca, nap; mutant |
Domain d4l04b_: 4l04 B: [235250] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d1t0la_ complexed with akg, ca, nap; mutant |
Domain d4l04c1: 4l04 C:4-414 [240461] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d4l04b_ complexed with akg, ca, nap; mutant |
Domain d4l04d_: 4l04 D: [240462] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d4l04b_ complexed with akg, ca, nap; mutant |
Domain d4l04e1: 4l04 E:4-414 [240463] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d4l04b_ complexed with akg, ca, nap; mutant |
Domain d4l04f_: 4l04 F: [240464] Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2 automated match to d4l04b_ complexed with akg, ca, nap; mutant |
Domain d4l06a1: 4l06 A:3-414 [224539] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d4l06b_: 4l06 B: [224540] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d4l06c_: 4l06 C: [224541] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d4l06d_: 4l06 D: [224542] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d4l06e1: 4l06 E:3-414 [224543] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d4l06f_: 4l06 F: [224544] Other proteins in same PDB: d4l06a2, d4l06e2 automated match to d3inmb_ complexed with akg, ca, nap; mutant |
Domain d5de1a_: 5de1 A: [277861] automated match to d1t0la_ complexed with 59d, nap |
Domain d5de1b_: 5de1 B: [277860] automated match to d1t0la_ complexed with 59d, nap |
Domain d5l57a_: 5l57 A: [327179] automated match to d1t0la_ complexed with 6n3, ndp |
Domain d5l58a_: 5l58 A: [327177] automated match to d1t0la_ complexed with 6mx, ndp |
Domain d5lgea1: 5lge A:3-414 [329495] Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2 automated match to d1t0la_ complexed with 6vn, act, edo, nap; mutant |
Domain d5lgeb1: 5lge B:3-414 [329476] Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2 automated match to d1t0la_ complexed with 6vn, act, edo, nap; mutant |
Domain d5lgec1: 5lge C:2-414 [329478] Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2 automated match to d1t0la_ complexed with 6vn, act, edo, nap; mutant |
Domain d5lged1: 5lge D:3-414 [329511] Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2 automated match to d1t0la_ complexed with 6vn, act, edo, nap; mutant |
Domain d5suna_: 5sun A: [329541] automated match to d1t0la_ complexed with 70q, dms, edo, ndp, so4 |
Domain d5sunb_: 5sun B: [329522] automated match to d1t0la_ complexed with 70q, dms, edo, ndp, so4 |
Domain d5svfa_: 5svf A: [329571] automated match to d1t0la_ complexed with 70p, flc, ndp |
Domain d5svfb_: 5svf B: [329533] automated match to d1t0la_ complexed with 70p, flc, ndp |
Domain d5svfc_: 5svf C: [329524] automated match to d1t0la_ complexed with 70p, flc, ndp |
Domain d5svfd_: 5svf D: [329530] automated match to d1t0la_ complexed with 70p, flc, ndp |
Domain d5tqha_: 5tqh A: [329009] automated match to d1t0la_ complexed with 7j2, flc, ndp; mutant |
Domain d5tqhb_: 5tqh B: [329108] automated match to d1t0la_ complexed with 7j2, flc, ndp; mutant |
Domain d5tqhc_: 5tqh C: [329014] automated match to d1t0la_ complexed with 7j2, flc, ndp; mutant |
Domain d5tqhd_: 5tqh D: [329032] automated match to d1t0la_ complexed with 7j2, flc, ndp; mutant |
Domain d5yfma_: 5yfm A: [340721] automated match to d1t0la_ complexed with mg, nap |
Domain d5yfmb_: 5yfm B: [340751] automated match to d1t0la_ complexed with mg, nap |
Domain d5yfmc_: 5yfm C: [340807] automated match to d1t0la_ complexed with mg, nap |
Domain d5yfna1: 5yfn A:1-411 [340740] Other proteins in same PDB: d5yfna2, d5yfnb2 automated match to d1t0la_ complexed with ict, k, mg |
Domain d5yfnb1: 5yfn B:1-412 [340752] Other proteins in same PDB: d5yfna2, d5yfnb2 automated match to d1t0la_ complexed with ict, k, mg |
Domain d6b0za_: 6b0z A: [341343] automated match to d1t0la_ complexed with c81, flc, ndp; mutant |
Domain d6b0zb_: 6b0z B: [341187] automated match to d1t0la_ complexed with c81, flc, ndp; mutant |
Domain d6b0zc_: 6b0z C: [341183] automated match to d1t0la_ complexed with c81, flc, ndp; mutant |
Domain d6b0zd_: 6b0z D: [341180] automated match to d1t0la_ complexed with c81, flc, ndp; mutant |
Domain d6bkxa1: 6bkx A:3-414 [355254] Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2 automated match to d1t0la_ complexed with ca, dwp, ict |
Domain d6bkxb1: 6bkx B:3-414 [355192] Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2 automated match to d1t0la_ complexed with ca, dwp, ict |
Domain d6bkxc1: 6bkx C:3-414 [355089] Other proteins in same PDB: d6bkxa2, d6bkxb2, d6bkxc2 automated match to d1t0la_ complexed with ca, dwp, ict |
Domain d6bkya1: 6bky A:3-414 [355314] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkyb1: 6bky B:3-414 [355346] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkyc1: 6bky C:3-414 [355146] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkyd1: 6bky D:3-414 [355264] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkye1: 6bky E:3-414 [355364] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkyf1: 6bky F:3-414 [355217] Other proteins in same PDB: d6bkya2, d6bkyb2, d6bkyc2, d6bkyd2, d6bkye2, d6bkyf2 automated match to d1t0la_ complexed with k32, lmr, mg |
Domain d6bkza_: 6bkz A: [355090] automated match to d1t0la_ complexed with dwm, nap |
Domain d6bkzb_: 6bkz B: [355305] automated match to d1t0la_ complexed with dwm, nap |
Domain d6bl0a1: 6bl0 A:3-414 [355222] Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2 automated match to d1t0la_ complexed with dwj, ict, mg, nap |
Domain d6bl0b1: 6bl0 B:3-414 [355091] Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2 automated match to d1t0la_ complexed with dwj, ict, mg, nap |
Domain d6bl0c1: 6bl0 C:3-414 [355291] Other proteins in same PDB: d6bl0a2, d6bl0b2, d6bl0c2 automated match to d1t0la_ complexed with dwj, ict, mg, nap |
Domain d6bl1a1: 6bl1 A:3-414 [355357] Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2 automated match to d1t0la_ complexed with ca, dwg, ict |
Domain d6bl1b1: 6bl1 B:3-414 [355353] Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2 automated match to d1t0la_ complexed with ca, dwg, ict |
Domain d6bl1c1: 6bl1 C:3-414 [355184] Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2 automated match to d1t0la_ complexed with ca, dwg, ict |
Domain d6bl2a1: 6bl2 A:3-414 [355327] Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2 automated match to d1t0la_ complexed with ca, dws, ict |
Domain d6bl2b1: 6bl2 B:3-414 [355177] Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2 automated match to d1t0la_ complexed with ca, dws, ict |
Domain d6bl2c1: 6bl2 C:3-414 [355092] Other proteins in same PDB: d6bl2a2, d6bl2b2, d6bl2c2 automated match to d1t0la_ complexed with ca, dws, ict |
Domain d6io0a_: 6io0 A: [376199] automated match to d1t0la_ complexed with aou, cit, gol, ndp; mutant |
Domain d6io0b_: 6io0 B: [376206] automated match to d1t0la_ complexed with aou, cit, gol, ndp; mutant |
Domain d6o2ya1: 6o2y A:3-414 [370972] Other proteins in same PDB: d6o2ya2 automated match to d1t0la_ complexed with bme, ljy, nap; mutant |
Domain d6o2yb_: 6o2y B: [370969] Other proteins in same PDB: d6o2ya2 automated match to d1t0la_ complexed with bme, ljy, nap; mutant |
Domain d6o2yc_: 6o2y C: [370961] Other proteins in same PDB: d6o2ya2 automated match to d1t0la_ complexed with bme, ljy, nap; mutant |
Domain d6o2za1: 6o2z A:3-414 [371022] Other proteins in same PDB: d6o2za2, d6o2zb2 automated match to d1t0la_ complexed with gol, ljv, nap; mutant |
Domain d6o2zb1: 6o2z B:3-414 [370999] Other proteins in same PDB: d6o2za2, d6o2zb2 automated match to d1t0la_ complexed with gol, ljv, nap; mutant |
Domain d6paya_: 6pay A: [374398] automated match to d1t0la_ complexed with fmt, ict, mg, ndp |
Domain d6payb_: 6pay B: [374311] automated match to d1t0la_ complexed with fmt, ict, mg, ndp |
Domain d6payc_: 6pay C: [374291] automated match to d1t0la_ complexed with fmt, ict, mg, ndp |
Domain d6payd_: 6pay D: [374347] automated match to d1t0la_ complexed with fmt, ict, mg, ndp |
Domain d6u4ja1: 6u4j A:3-414 [381955] Other proteins in same PDB: d6u4ja2 automated match to d1t0la_ complexed with cl, flc, nap, pwv; mutant |
Domain d6u4jb_: 6u4j B: [381913] Other proteins in same PDB: d6u4ja2 automated match to d1t0la_ complexed with cl, flc, nap, pwv; mutant |
Domain d6veia1: 6vei A:3-414 [380285] Other proteins in same PDB: d6veia2, d6veib2 automated match to d1t0la_ complexed with 33o, 9uo, act, mla, mlt, ndp, peg, so4; mutant |
Domain d6veib1: 6vei B:3-414 [380265] Other proteins in same PDB: d6veia2, d6veib2 automated match to d1t0la_ complexed with 33o, 9uo, act, mla, mlt, ndp, peg, so4; mutant |
Domain d6vg0a_: 6vg0 A: [380306] Other proteins in same PDB: d6vg0b2 automated match to d1t0la_ complexed with ndp, qwm; mutant |
Domain d6vg0b1: 6vg0 B:2-414 [380273] Other proteins in same PDB: d6vg0b2 automated match to d1t0la_ complexed with ndp, qwm; mutant |
Domain d6vg0c_: 6vg0 C: [380257] Other proteins in same PDB: d6vg0b2 automated match to d1t0la_ complexed with ndp, qwm; mutant |
Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries) |
Domain d1j1wa_: 1j1w A: [90772] complexed with nap |
Domain d1j1wb_: 1j1w B: [90773] complexed with nap |
Domain d1j1wc_: 1j1w C: [90774] complexed with nap |
Domain d1j1wd_: 1j1w D: [90775] complexed with nap |
Domain d1lwda_: 1lwd A: [78265] complexed with ict, mn, so4 |
Domain d1lwdb_: 1lwd B: [78266] complexed with ict, mn, so4 |
Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: