Lineage for Protein: NADP-dependent isocitrate dehydrogenase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2138632Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2138633Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2138634Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 protein domains)
    the active site is between the two identical subunits
  6. 2138728Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

Species:

  1. 2138729Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
    Uniprot O75874
    1. Domains for 1t09:
      1. 2138749Domain d1t09a_: 1t09 A: [106197]
        complexed with nap
      2. 2138750Domain d1t09b_: 1t09 B: [106198]
        complexed with nap
    2. Domains for 1t0l:
      1. 2138739Domain d1t0la_: 1t0l A: [106216]
        complexed with ca, ict, nap
      2. 2138740Domain d1t0lb_: 1t0l B: [106217]
        complexed with ca, ict, nap
      3. 2138741Domain d1t0lc_: 1t0l C: [106218]
        complexed with ca, ict, nap
      4. 2138742Domain d1t0ld_: 1t0l D: [106219]
        complexed with ca, ict, nap
    3. Domains for 3inm:
      1. 2138736Domain d3inma_: 3inm A: [178460]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
      2. 2138737Domain d3inmb_: 3inm B: [178461]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
      3. 2138738Domain d3inmc_: 3inm C: [178462]
        automated match to d1t09a_
        protein/RNA complex; complexed with akg, ca, gol, na, ndp; mutant
    4. Domains for 3map:
      1. 2138759Domain d3mapa_: 3map A: [180990]
        automated match to d1t09a_
        complexed with ict, nap; mutant
      2. 2138760Domain d3mapb_: 3map B: [180991]
        automated match to d1t09a_
        complexed with ict, nap; mutant
    5. Domains for 4kzo:
      1. 2138733Domain d4kzoa1: 4kzo A:3-414 [224533]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      2. 2138734Domain d4kzob_: 4kzo B: [224534]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      3. 2138735Domain d4kzoc_: 4kzo C: [224535]
        Other proteins in same PDB: d4kzoa2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
    6. Domains for 4l03:
      1. 2138730Domain d4l03a1: 4l03 A:3-414 [224536]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      2. 2138731Domain d4l03b_: 4l03 B: [224537]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
      3. 2138732Domain d4l03c1: 4l03 C:3-414 [224538]
        Other proteins in same PDB: d4l03a2, d4l03c2
        automated match to d3inmb_
        complexed with akg, ca, edo, nap; mutant
    7. Domains for 4l04:
      1. 2138751Domain d4l04a1: 4l04 A:5-414 [240460]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      2. 2138752Domain d4l04b_: 4l04 B: [235250]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d1t0la_
        complexed with akg, ca, nap; mutant
      3. 2138753Domain d4l04c1: 4l04 C:4-414 [240461]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      4. 2138754Domain d4l04d_: 4l04 D: [240462]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      5. 2138755Domain d4l04e1: 4l04 E:4-414 [240463]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
      6. 2138756Domain d4l04f_: 4l04 F: [240464]
        Other proteins in same PDB: d4l04a2, d4l04c2, d4l04e2
        automated match to d4l04b_
        complexed with akg, ca, nap; mutant
    8. Domains for 4l06:
      1. 2138743Domain d4l06a1: 4l06 A:3-414 [224539]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      2. 2138744Domain d4l06b_: 4l06 B: [224540]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      3. 2138745Domain d4l06c_: 4l06 C: [224541]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      4. 2138746Domain d4l06d_: 4l06 D: [224542]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      5. 2138747Domain d4l06e1: 4l06 E:3-414 [224543]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
      6. 2138748Domain d4l06f_: 4l06 F: [224544]
        Other proteins in same PDB: d4l06a2, d4l06e2
        automated match to d3inmb_
        complexed with akg, ca, nap; mutant
    9. Domains for 5de1:
      1. 2138757Domain d5de1a_: 5de1 A: [277861]
        automated match to d1t0la_
        complexed with 59d, nap
      2. 2138758Domain d5de1b_: 5de1 B: [277860]
        automated match to d1t0la_
        complexed with 59d, nap
    10. Domain for 5l57:
    11. Domain for 5l58:
    12. Domains for 5lge:
      1. 2286175Domain d5lgeb1: 5lge B:3-414 [329476]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      2. 2286177Domain d5lgec1: 5lge C:2-414 [329478]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      3. 2286194Domain d5lgea1: 5lge A:3-414 [329495]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
      4. 2286210Domain d5lged1: 5lge D:3-414 [329511]
        Other proteins in same PDB: d5lgea2, d5lgeb2, d5lgec2, d5lged2
        automated match to d1t0la_
        complexed with 6vn, act, edo, nap; mutant
    13. Domains for 5sun:
      1. 2286221Domain d5sunb_: 5sun B: [329522]
        automated match to d1t0la_
        complexed with 70q, dms, edo, ndp, so4
      2. 2286240Domain d5suna_: 5sun A: [329541]
        automated match to d1t0la_
        complexed with 70q, dms, edo, ndp, so4
    14. Domains for 5svf:
      1. 2286223Domain d5svfc_: 5svf C: [329524]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      2. 2286229Domain d5svfd_: 5svf D: [329530]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      3. 2286232Domain d5svfb_: 5svf B: [329533]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
      4. 2286270Domain d5svfa_: 5svf A: [329571]
        automated match to d1t0la_
        complexed with 70p, flc, ndp
    15. Domains for 5tqh:
      1. 2285708Domain d5tqha_: 5tqh A: [329009]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      2. 2285713Domain d5tqhc_: 5tqh C: [329014]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      3. 2285731Domain d5tqhd_: 5tqh D: [329032]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
      4. 2285807Domain d5tqhb_: 5tqh B: [329108]
        automated match to d1t0la_
        complexed with 7j2, flc, ndp; mutant
    16. Domains for 5yfm:
      1. 2297420Domain d5yfma_: 5yfm A: [340721]
        automated match to d1t0la_
        complexed with mg, nap
      2. 2297450Domain d5yfmb_: 5yfm B: [340751]
        automated match to d1t0la_
        complexed with mg, nap
      3. 2297506Domain d5yfmc_: 5yfm C: [340807]
        automated match to d1t0la_
        complexed with mg, nap
    17. Domains for 5yfn:
      1. 2297439Domain d5yfna1: 5yfn A:1-411 [340740]
        Other proteins in same PDB: d5yfna2, d5yfnb2
        automated match to d1t0la_
        complexed with ict, k, mg
      2. 2297451Domain d5yfnb1: 5yfn B:1-412 [340752]
        Other proteins in same PDB: d5yfna2, d5yfnb2
        automated match to d1t0la_
        complexed with ict, k, mg
    18. Domains for 6b0z:
      1. 2297879Domain d6b0zd_: 6b0z D: [341180]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      2. 2297882Domain d6b0zc_: 6b0z C: [341183]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      3. 2297886Domain d6b0zb_: 6b0z B: [341187]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
      4. 2298042Domain d6b0za_: 6b0z A: [341343]
        automated match to d1t0la_
        complexed with c81, flc, ndp; mutant
  2. 2138761Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)
    1. Domains for 1j1w:
      1. 2138764Domain d1j1wa_: 1j1w A: [90772]
        complexed with nap
      2. 2138765Domain d1j1wb_: 1j1w B: [90773]
        complexed with nap
      3. 2138766Domain d1j1wc_: 1j1w C: [90774]
        complexed with nap
      4. 2138767Domain d1j1wd_: 1j1w D: [90775]
        complexed with nap
    2. Domains for 1lwd:
      1. 2138762Domain d1lwda_: 1lwd A: [78265]
        complexed with ict, mn, so4
      2. 2138763Domain d1lwdb_: 1lwd B: [78266]
        complexed with ict, mn, so4

More info for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases:

  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases first appeared in SCOP 1.63
  • Protein NADP-dependent isocitrate dehydrogenase from c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.05