Lineage for Protein: Tyrosine phosphatase

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2875105Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2875106Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2875255Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4
  6. 2875300Protein Tyrosine phosphatase [52806] (7 species)

Species:

  1. 2875301Human (Homo sapiens), 1B [TaxId:9606] [52807] (268 PDB entries)
    Uniprot P18031 2-300 ! Uniprot P18031 1-298 ! Uniprot P18031 2-299
    1. Domain for 1a5y:
    2. Domain for 1aax:
    3. Domain for 1bzc:
    4. Domain for 1bzh:
    5. Domain for 1bzj:
    6. Domain for 1c83:
    7. Domain for 1c84:
    8. Domain for 1c85:
    9. Domain for 1c86:
    10. Domain for 1c87:
    11. Domain for 1c88:
    12. Domain for 1ecv:
    13. Domain for 1een:
    14. Domain for 1eeo:
    15. Domain for 1g1f:
    16. Domain for 1g1g:
    17. Domain for 1g1h:
    18. Domain for 1g7f:
    19. Domain for 1g7g:
    20. Domain for 1gfy:
    21. Domain for 1i57:
    22. Domains for 1jf7:
      1. 2875427Domain d1jf7a_: 1jf7 A: [66619]
        complexed with tbh
      2. 2875428Domain d1jf7b_: 1jf7 B: [66620]
        complexed with tbh
    23. Domain for 1kak:
    24. Domain for 1kav:
    25. Domain for 1l8g:
    26. Domains for 1lqf:
      1. 2875566Domain d1lqfa1: 1lqf A:501-783 [74187]
        Other proteins in same PDB: d1lqfa2, d1lqfb2, d1lqfc2, d1lqfd2
        complexed with bgd
      2. 2875567Domain d1lqfb1: 1lqf B:501-783 [74188]
        Other proteins in same PDB: d1lqfa2, d1lqfb2, d1lqfc2, d1lqfd2
        complexed with bgd
      3. 2875568Domain d1lqfc1: 1lqf C:501-783 [74189]
        Other proteins in same PDB: d1lqfa2, d1lqfb2, d1lqfc2, d1lqfd2
        complexed with bgd
      4. 2875569Domain d1lqfd1: 1lqf D:501-783 [74190]
        Other proteins in same PDB: d1lqfa2, d1lqfb2, d1lqfc2, d1lqfd2
        complexed with bgd
    27. Domain for 1n6w:
    28. Domain for 1nl9:
    29. Domain for 1nny:
    30. Domain for 1no6:
    31. Domain for 1nwe:
    32. Domain for 1nwl:
    33. Domain for 1nz7:
    34. Domain for 1oem:
    35. Domain for 1oeo:
    36. Domain for 1oes:
    37. Domain for 1oet:
    38. Domain for 1oeu:
    39. Domain for 1oev:
    40. Domain for 1ony:
    41. Domain for 1onz:
    42. Domain for 1pa1:
    43. Domain for 1ph0:
    44. Domain for 1ptt:
    45. Domain for 1ptu:
    46. Domain for 1ptv:
    47. Domain for 1pty:
    48. Domain for 1pxh:
    49. Domain for 1pyn:
    50. Domain for 1q1m:
    51. Domain for 1q6j:
    52. Domain for 1q6m:
    53. Domains for 1q6n:
      1. 2875518Domain d1q6na1: 1q6n A:501-785 [95984]
        Other proteins in same PDB: d1q6na2, d1q6nb2
        complexed with cl, mg, p90
      2. 2875519Domain d1q6nb1: 1q6n B:1001-1285 [95985]
        Other proteins in same PDB: d1q6na2, d1q6nb2
        complexed with cl, mg, p90
    54. Domains for 1q6p:
      1. 2875549Domain d1q6pa1: 1q6p A:501-783 [95988]
        Other proteins in same PDB: d1q6pa2, d1q6pb2
        complexed with 213, cl
      2. 2875550Domain d1q6pb1: 1q6p B:1001-1283 [95989]
        Other proteins in same PDB: d1q6pa2, d1q6pb2
        complexed with 213, cl
    55. Domains for 1q6s:
      1. 2875534Domain d1q6sa1: 1q6s A:501-785 [95994]
        Other proteins in same PDB: d1q6sa2, d1q6sb2
        complexed with 214, cl, mg, mpd
      2. 2875535Domain d1q6sb1: 1q6s B:1001-1285 [95995]
        Other proteins in same PDB: d1q6sa2, d1q6sb2
        complexed with 214, cl, mg, mpd
    56. Domains for 1q6t:
      1. 2875547Domain d1q6ta1: 1q6t A:501-785 [95996]
        Other proteins in same PDB: d1q6ta2, d1q6tb2
        complexed with 600, mg
      2. 2875548Domain d1q6tb1: 1q6t B:1001-1285 [95997]
        Other proteins in same PDB: d1q6ta2, d1q6tb2
        complexed with 600, mg
    57. Domain for 1qxk:
    58. Domain for 1sug:
    59. Domain for 1t48:
    60. Domain for 1t49:
    61. Domain for 1t4j:
    62. Domain for 1wax:
    63. Domain for 1xbo:
    64. Domain for 2azr:
    65. Domain for 2b07:
    66. Domains for 2b4s:
      1. 2875419Domain d2b4sa_: 2b4s A: [127853]
        Other proteins in same PDB: d2b4sb_, d2b4sd_
        automated match to d1eena_
        complexed with so4
      2. 2875420Domain d2b4sc_: 2b4s C: [161389]
        Other proteins in same PDB: d2b4sb_, d2b4sd_
        automated match to d1eena_
        complexed with so4
    67. Domain for 2bgd:
    68. Domain for 2bge:
    69. Domain for 2cm7:
    70. Domain for 2cm8:
    71. Domain for 2cnf:
    72. Domain for 2cng:
    73. Domain for 2cnh:
    74. Domain for 2cni:
    75. Domain for 2f6f:
    76. Domain for 2f6t:
    77. Domain for 2f6v:
    78. Domain for 2f6w:
    79. Domain for 2f6y:
    80. Domain for 2f6z:
    81. Domain for 2f70:
    82. Domain for 2f71:
    83. Domains for 2fjm:
      1. 2875510Domain d2fjma1: 2fjm A:501-785 [204221]
        Other proteins in same PDB: d2fjma2, d2fjmb2
        automated match to d1suga_
        complexed with 073, cl, mg
      2. 2875511Domain d2fjmb1: 2fjm B:501-785 [204222]
        Other proteins in same PDB: d2fjma2, d2fjmb2
        automated match to d1suga_
        complexed with 073, cl, mg
    84. Domains for 2fjn:
      1. 2875539Domain d2fjna1: 2fjn A:501-785 [197918]
        Other proteins in same PDB: d2fjna2, d2fjnb2
        automated match to d1q6sa_
        complexed with 073, cl
      2. 2875540Domain d2fjnb1: 2fjn B:501-785 [191829]
        Other proteins in same PDB: d2fjna2, d2fjnb2
        automated match to d2f6fa_
        complexed with 073, cl
    85. Domain for 2h4g:
    86. Domain for 2h4k:
    87. Domain for 2hb1:
    88. Domain for 2hnp:
    89. Domain for 2hnq:
    90. Domain for 2nt7:
    91. Domain for 2nta:
    92. Domain for 2qbp:
    93. Domain for 2qbq:
    94. Domain for 2qbr:
    95. Domain for 2qbs:
    96. Domain for 2veu:
    97. Domain for 2vev:
    98. Domain for 2vew:
    99. Domain for 2vex:
    100. Domain for 2vey:
    101. Domain for 2zmm:
    102. Domain for 2zn7:
    103. Domain for 3cwe:
    104. Domain for 3d9c:
    105. Domain for 3eax:
    106. Domain for 3eb1:
    107. Domain for 3eu0:
    108. Domain for 3i80:
    109. Domain for 3qkp:
    110. Domain for 3qkq:
    111. Domain for 3sme:
    112. Domain for 3zv2:
    113. Domain for 4i8n:
    114. Domain for 4qah:
    115. Domain for 4qap:
    116. Domain for 4qbe:
    117. Domain for 4qbw:
    118. Domains for 4y14:
      1. 2875460Domain d4y14a_: 4y14 A: [275722]
        automated match to d2cnia_
        complexed with c0a, cl, gol, trs
      2. 2875461Domain d4y14b_: 4y14 B: [275721]
        automated match to d2cnia_
        complexed with c0a, cl, gol, trs
    119. Domain for 5k9v:
    120. Domain for 5k9w:
    121. Domain for 5ka2:
    122. Domain for 5ka3:
    123. Domain for 5ka4:
    124. Domain for 5ka7:
    125. Domain for 5ka8:
    126. Domain for 5ka9:
    127. Domain for 5kac:
    128. Domains for 5kad:
      1. 2875457Domain d5kada1: 5kad A:1-281 [330415]
        Other proteins in same PDB: d5kada2, d5kadb2
        automated match to d4y14b_
        complexed with cl, gol, ota, trs; mutant
      2. 2875458Domain d5kadb1: 5kad B:1-282 [330401]
        Other proteins in same PDB: d5kada2, d5kadb2
        automated match to d4y14b_
        complexed with cl, gol, ota, trs; mutant
    129. Domain for 5qde:
    130. Domain for 5qdf:
    131. Domain for 5qdg:
    132. Domain for 5qdh:
    133. Domain for 5qdi:
    134. Domain for 5qdj:
    135. Domain for 5qdk:
    136. Domain for 5qdl:
    137. Domain for 5qdm:
    138. Domain for 5qdn:
    139. Domain for 5qdo:
    140. Domain for 5qdp:
    141. Domain for 5qdq:
    142. Domain for 5qdr:
    143. Domain for 5qds:
    144. Domain for 5qdt:
    145. Domain for 5qdu:
    146. Domain for 5qdv:
    147. Domain for 5qdw:
    148. Domain for 5qdx:
    149. Domain for 5qdy:
    150. Domain for 5qdz:
    151. Domain for 5qe0:
    152. Domain for 5qe1:
    153. Domain for 5qe2:
    154. Domain for 5qe3:
    155. Domain for 5qe4:
    156. Domain for 5qe5:
    157. Domain for 5qe6:
    158. Domain for 5qe7:
    159. Domain for 5qe8:
    160. Domain for 5qe9:
    161. Domain for 5qea:
    162. Domain for 5qeb:
    163. Domain for 5qec:
    164. Domain for 5qed:
    165. Domain for 5qee:
    166. Domain for 5qef:
    167. Domain for 5qeg:
    168. Domain for 5qeh:
    169. Domain for 5qei:
    170. Domain for 5qej:
    171. Domain for 5qek:
    172. Domain for 5qel:
    173. Domain for 5qem:
    174. Domain for 5qen:
    175. Domain for 5qeo:
    176. Domain for 5qep:
    177. Domain for 5qeq:
    178. Domain for 5qer:
    179. Domain for 5qes:
    180. Domain for 5qet:
    181. Domain for 5qeu:
    182. Domain for 5qev:
    183. Domain for 5qew:
    184. Domain for 5qex:
    185. Domain for 5qey:
    186. Domain for 5qez:
    187. Domain for 5qf0:
    188. Domain for 5qf1:
    189. Domain for 5qf2:
    190. Domain for 5qf3:
    191. Domain for 5qf4:
    192. Domain for 5qf5:
    193. Domain for 5qf6:
    194. Domain for 5qf7:
    195. Domain for 5qf8:
    196. Domain for 5qf9:
    197. Domain for 5qfa:
    198. Domain for 5qfb:
    199. Domain for 5qfc:
    200. Domain for 5qfd:
    201. Domain for 5qfe:
    202. Domain for 5qff:
    203. Domain for 5qfg:
    204. Domain for 5qfh:
    205. Domain for 5qfi:
    206. Domain for 5qfj:
    207. Domain for 5qfk:
    208. Domain for 5qfl:
    209. Domain for 5qfm:
    210. Domain for 5qfn:
    211. Domain for 5qfo:
    212. Domain for 5qfp:
    213. Domain for 5qfq:
    214. Domain for 5qfr:
    215. Domain for 5qfs:
    216. Domain for 5qft:
    217. Domain for 5qfu:
    218. Domain for 5qfv:
    219. Domain for 5qfw:
    220. Domain for 5qfx:
    221. Domain for 5qfy:
    222. Domain for 5qfz:
    223. Domain for 5qg0:
    224. Domain for 5qg1:
    225. Domain for 5qg2:
    226. Domain for 5qg3:
    227. Domain for 5qg4:
    228. Domain for 5qg5:
    229. Domain for 5qg6:
    230. Domain for 5qg7:
    231. Domain for 5qg8:
    232. Domain for 5qg9:
    233. Domain for 5qga:
    234. Domain for 5qgb:
    235. Domain for 5qgc:
    236. Domain for 5qgd:
    237. Domain for 5qge:
    238. Domain for 5qgf:
    239. Domain for 5t19:
    240. Domain for 6b8e:
    241. Domain for 6b8t:
    242. Domain for 6b8x:
    243. Domain for 6b8z:
    244. Domain for 6b90:
    245. Domain for 6b95:
    246. Domain for 6bai:
    247. Domain for 6cwu:
    248. Domain for 6cwv:
    249. Domain for 6ol4:
    250. Domain for 6olq:
    251. Domain for 6olv:
    252. Domain for 6omy:
    253. Domain for 6pfw:
    254. Domain for 6pg0:
    255. Domain for 6pgt:
    256. Domain for 6pha:
    257. Domain for 6phs:
    258. Domain for 6pm8:
    259. Domain for 6w30:
    260. Domain for 7ken:
    261. Domain for 7l0c:
    262. Domain for 7l0h:
    263. Domain for 7lfo:
    264. Domain for 7mm1:
    265. Domain for 7mn7:
    266. Domain for 7mnb:
    267. Domain for 7mnf:
    268. Domain for 7mow:
  2. 2875579Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry)
    receptor protein tyrosine phosphatase mu, domain 1
  3. 2875582Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (4 PDB entries)
    1. Domain for 1fpr:
      • 2875586Domain d1fpra_: 1fpr A: [59949]
        complex with an in vitro peptide substrate py469 derived from shps-1, chain B
    2. Domain for 1gwz:
    3. Domain for 4gry:
    4. Domain for 4grz:
  4. 2875587Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)
  5. 2875590Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry)
    non-receptor type 2
  6. 2875592Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry)
    receptor protein tyrosine phosphatase alpha, domain 1
  7. 2875595Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry)

More info for Protein Tyrosine phosphatase from c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Timeline for Protein Tyrosine phosphatase from c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases: