PDB entry 7ken

View 7ken on RCSB PDB site
Description: Protein Tyrosine Phosphatase 1B, D289A mutant, apo state
Class: hydrolase
Keywords: Protein Phosphatase, Signaling Enzyme, Drug Target, HYDROLASE
Deposited on 2020-10-11, released 2021-03-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (7-End)
      • engineered mutation (294)
    Domains in SCOPe 2.08: d7kena_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kenA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqaqwkel
shedlepppehipppprppkrilephngk

    Sequence, based on observed residues (ATOM records): (download) 
    >7kenA (A:)
emekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklhq
edndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslkc
aqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwpd
fgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkdp
ssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqaqwkelshedl