Lineage for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2454571Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2454572Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2454684Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 protein domains)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Protein Domains:

  1. 2454685Protein-tyrosine phosphatase alpha [102420] (1 species)
  2. 2454689Protein-tyrosine phosphatase YopH, catalytic domain [100952] (2 species)
    1. 2454690Species Yersinia enterocolitica [TaxId:34055] [225588] (3 PDB entries)
    2. 2454694Species Yersinia enterocolitica [TaxId:630] [52812] (19 PDB entries)
  3. 2454718RPTP Lar [52815] (1 species)
    duplication: tandem repeat of the phosphatase domain
  4. 2454724SptP tyrosine phosphatase, catalytic domain [52813] (1 species)
  5. 2454728Tyrosine phosphatase [52806] (7 species)
    1. 2454729Species Human (Homo sapiens), 1B [TaxId:9606] [52807] (245 PDB entries)
      Uniprot P18031 2-300 ! Uniprot P18031 1-298 ! Uniprot P18031 2-299
    2. 2454871Species Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry)
      receptor protein tyrosine phosphatase mu, domain 1
    3. 2454874Species Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (4 PDB entries)
    4. 2454879Species Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)
    5. 2454882Species Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry)
      non-receptor type 2
    6. 2454884Species Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry)
      receptor protein tyrosine phosphatase alpha, domain 1
    7. 2454887Species Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry)
  6. 2454889Tyrosine-protein phosphatase, non-receptor type 13 (PTPL1) [117581] (1 species)
  7. 2454892automated matches [190252] (4 species)
    not a true protein
    1. 2454893Species Human (Homo sapiens) [TaxId:9606] [187034] (36 PDB entries)
    2. 2454935Species Mouse (Mus musculus) [TaxId:10090] [233617] (1 PDB entry)
    3. 2454938Species Yersinia enterocolitica [TaxId:630] [226454] (1 PDB entry)
    4. 3056645Species Yersinia pestis [TaxId:632] [356707] (5 PDB entries)

More info for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Timeline for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases: