PDB entry 2fjn

View 2fjn on RCSB PDB site
Description: The structure of phosphotyrosine phosphatase 1B in complex with compound 2
Class: hydrolase
Keywords: phosphatase, secondary binding site, selectivity, hydrolase
Deposited on 2006-01-03, released 2006-01-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase, non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (12-End)
      • cloning artifact (8-11)
    Domains in SCOPe 2.08: d2fjna1, d2fjna2
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase, non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (12-End)
      • cloning artifact (8-11)
    Domains in SCOPe 2.08: d2fjnb1, d2fjnb2
  • Heterogens: CL, 073, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fjnA (A:)
mdykddddklefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrd
vspfdhsriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvv
mlnrvmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqet
reilhfhyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcla
dtclllmdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvq
dqwkelshed

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjnA (A:)
klefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsr
iklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmek
gslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhy
ttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmd
krkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgds

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fjnB (B:)
mdykddddklefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrd
vspfdhsriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvv
mlnrvmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqet
reilhfhyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcla
dtclllmdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvq
dqwkelshed

    Sequence, based on observed residues (ATOM records): (download) 
    >2fjnB (B:)
klefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsr
iklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmek
gslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhy
ttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmd
krkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgds